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License Agreements - Novartis (Details) - USD ($) $ in Thousands	1 Months Ended	3 Months Ended		6 Months Ended		164 Months Ended
	Nov. 30, 2009	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Dec. 31, 2022
License Agreements
Total revenues		$ 954,610	$ 911,397	$ 1,763,283	$ 1,644,632
Product royalty revenues
License Agreements
Total revenues		127,605	117,546	243,041	239,960
JAKAFI
License Agreements
Total revenues		682,384	597,673	1,262,353	1,142,137
Milestone and contract revenues
License Agreements
Total revenues		0	130,000	0	135,000
Novartis
License Agreements
Royalties payable		310,300		310,300		$ 310,300	$ 253,500
Novartis | JAKAVI | Non-US
License Agreements
Royalties payable on net sales		90,400	83,700	167,100	154,600
Novartis | JAKAFI | UNITED STATES
License Agreements
Royalties payable on net sales		33,500	29,300	56,900	51,000
Novartis | Milestone and contract revenues
License Agreements
Total revenues		0	60,000	0	60,000
Novartis | TABRECTA PROD SERV | Non-US
License Agreements
Royalties payable on net sales		$ 4,800	$ 3,600	$ 9,000	$ 7,100
Minimum | Novartis | JAKAVI
License Agreements
Royalty payments on future global net sales (as a percent)				12.00%
Maximum | Novartis | JAKAVI
License Agreements
Royalty payments on future global net sales (as a percent)				14.00%
Development Milestones | Novartis
License Agreements
Amount recognized and received for the achievement of a predefined milestone						157,000
Development Milestones | Maximum | Novartis
License Agreements
Upfront and immediate milestone payment to be received under license agreement	$ 174,000
Regulatory Milestones | Novartis
License Agreements
Amount recognized and received for the achievement of a predefined milestone						340,000
Regulatory Milestones | Maximum | Novartis
License Agreements
Upfront and immediate milestone payment to be received under license agreement	495,000
Commercialization Milestones | Novartis
License Agreements
Amount recognized and received for the achievement of a predefined milestone						$ 200,000
Commercialization Milestones | Maximum | Novartis
License Agreements
Upfront and immediate milestone payment to be received under license agreement	500,000
Development and Regulatory Milestones | Maximum | Novartis
License Agreements
Upfront and immediate milestone payment to be received under license agreement	$ 75,000

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