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License Agreements - Agenus (Details) - USD ($)
$ in Thousands
 1 Months Ended 3 Months Ended 6 Months Ended 102 Months Ended
Feb. 28, 2017
Jun. 30, 2023
Jun. 30, 2022
Jun. 30, 2023
Jun. 30, 2022
Jun. 30, 2023
May 31, 2023
Dec. 31, 2022
License Agreements                
Fair market long term investments   $ 170,316   $ 170,316   $ 170,316   $ 133,676 [1]
Unrealized gain (loss) on long term investments   $ 41,811 $ (24,897) $ 36,493 $ (71,482)      
Agenus                
License Agreements                
Common stock held from investment (in shares)   12,100,000   12,100,000   12,100,000    
Fair market long term investments   $ 19,300   $ 19,300   $ 19,300   $ 29,000
Unrealized gain (loss) on long term investments   900 $ (6,300) (9,700) $ (15,400)      
MiNK                
License Agreements                
Fair market long term investments   400   400   400    
Unrealized gain (loss) on long term investments   200            
Shares acquired due to distribution of dividend (in shares)             200,000  
Agenus                
License Agreements                
Period of notice for termination of license agreement 12 months              
Agenus | Development, Regulatory and Commercialization Milestones                
License Agreements                
Milestone payment made under license agreement           30,000    
Additional milestone payments under the license agreement   $ 500,000   $ 500,000   $ 500,000    
Royalty-bearing product other than GITR, OX40 and one undisclosed target | Minimum | Agenus                
License Agreements                
Royalty payments on future global net sales (as a percent) 6.00%              
Royalty-bearing product other than GITR, OX40 and one undisclosed target | Maximum | Agenus                
License Agreements                
Royalty payments on future global net sales (as a percent) 12.00%              
Royalty-bearing product GITR, OX40 and one undisclosed target | Maximum | Agenus                
License Agreements                
Royalty payments on future global net sales (as a percent) 15.00%              
[1] The condensed consolidated balance sheet at December 31, 2022 has been derived from the audited consolidated financial statements at that date.