XML 67 R53.htm IDEA: XBRL DOCUMENT v3.23.2
License Agreements - Syndax (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 6 Months Ended
Dec. 31, 2021
Sep. 30, 2021
Jun. 30, 2023
Jun. 30, 2022
Jun. 30, 2023
Jun. 30, 2022
Dec. 31, 2022
License Agreements              
Fair market long term investments     $ 170,316   $ 170,316   $ 133,676 [1]
Unrealized gain (loss) on long term investments     41,811 $ (24,897) 36,493 $ (71,482)  
Research and development     $ 400,750 347,196 $ 807,391 700,569  
Investment in Syndax              
License Agreements              
Common stock held from investment (in shares)     1,400,000   1,400,000    
Fair market long term investments     $ 29,800   $ 29,800   $ 36,200
Unrealized gain (loss) on long term investments     (200) $ 2,700 (6,400) $ (3,800)  
Syndax              
License Agreements              
Upfront payment under license agreement $ 117,000            
Research and development     6,200   11,800    
Syndax | Accrued Liabilities              
License Agreements              
Accrued and other liabilities     4,400   4,400    
Syndax | Development and Regulatory Milestones | Maximum              
License Agreements              
Additional milestone payments under the license agreement     220,000   220,000    
Syndax | Commercialization Milestones | Maximum              
License Agreements              
Additional milestone payments under the license agreement     $ 230,000   $ 230,000    
Syndax | Incyte              
License Agreements              
Funding of future development costs (as a percent)         55.00%    
UNITED STATES | Syndax | Syndax              
License Agreements              
Funding of future development costs (as a percent)   45.00%          
UNITED STATES | Syndax | Incyte              
License Agreements              
Funding of future development costs (as a percent)   55.00%          
[1] The condensed consolidated balance sheet at December 31, 2022 has been derived from the audited consolidated financial statements at that date.