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License Agreements - Syndax (Details) - USD ($) $ in Thousands | 1 Months Ended | 3 Months Ended | 9 Months Ended |
--- | --- | --- | --- | ---
Dec. 31, 2021 | Sep. 30, 2021 | Sep. 30, 2023 | Sep. 30, 2022 | Sep. 30, 2023 | Sep. 30, 2022 | Dec. 31, 2022
License Agreements |  |  |  |  |  |  |  |
Fair market long term investments |  |  | $ 153,663 |  | $ 153,663 |  | $ 133,676 | [1]
Unrealized gain (loss) on long term investments |  |  | (26,654) | $ (660) | 9,839 | $ (72,142) |  |
Research and development |  |  | $ 375,709 | 384,007 | $ 1,183,100 | 1,084,576 |  |
Investment in Syndax |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |
Common stock held from investment (in shares) |  |  | 1,400,000 |  | 1,400,000 |  |  |
Fair market long term investments |  |  | $ 20,600 |  | $ 20,600 |  | $ 36,200 |
Unrealized gain (loss) on long term investments |  |  | (9,200) | $ 6,800 | (15,600) | $ 3,100 |  |
Syndax |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |
Upfront payment under license agreement | $ 117,000 |  |  |  |  |  |  |
Research and development |  |  | 5,100 |  | 16,900 |  |  |
Syndax | Accrued Liabilities |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |
Accrued and other liabilities |  |  | 7,300 |  | 7,300 |  |  |
Syndax | Development and Regulatory Milestones | Maximum |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |
Additional milestone payments under the license agreement |  |  | 220,000 |  | 220,000 |  |  |
Syndax | Commercialization Milestones | Maximum |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |
Additional milestone payments under the license agreement |  |  | $ 230,000 |  | $ 230,000 |  |  |
Syndax | Incyte |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |
Funding of future development costs (as a percent) |  |  |  |  | 55.00% |  |  |
UNITED STATES | Syndax | Syndax |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |
Funding of future development costs (as a percent) |  | 45.00% |  |  |  |  |  |
UNITED STATES | Syndax | Incyte |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |
Funding of future development costs (as a percent) |  | 55.00% |  |  |  |  |  |
[1] | The condensed consolidated balance sheet at December 31, 2022 has been derived from the audited consolidated financial statements at that date.

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