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CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2023
Sep. 30, 2022
Sep. 30, 2023
Sep. 30, 2022
Revenues:        
Total revenues $ 919,025 $ 823,303 $ 2,682,308 $ 2,467,935
Costs and expenses:        
Cost of product revenues (including definite-lived intangible amortization) 60,091 54,584 185,239 147,834
Research and development 375,709 384,007 1,183,100 1,084,576
Selling, general and administrative 267,893 266,460 867,428 729,321
(Gain) loss on change in fair value of acquisition-related contingent consideration (426) (21,893) 14,144 (12,198)
Loss and (profit) sharing under collaboration agreements 1,053 1,769 (858) 9,055
Total costs and expenses 704,320 684,927 2,249,053 1,958,588
Income from operations 214,705 138,376 433,255 509,347
Interest income and other, net 46,371 11,513 121,912 13,295
Interest expense (623) (641) (1,747) (1,999)
Unrealized (loss) gain on long term investments (26,654) (660) 9,839 (72,142)
Income before provision for income taxes 233,799 148,588 563,259 448,501
Provision for income taxes 62,530 35,813 166,739 136,302
Net income $ 171,269 $ 112,775 $ 396,520 $ 312,199
Net income per share:        
Basic (in USD per share) $ 0.76 $ 0.51 $ 1.77 $ 1.41
Diluted (in USD per share) $ 0.76 $ 0.50 $ 1.76 $ 1.40
Shares used in computing net income per share:        
Basic (in shares) 224,078 222,415 223,428 221,801
Diluted (in shares) 226,167 224,175 225,756 223,626
Product revenues, net        
Revenues:        
Total revenues $ 783,197 $ 713,010 $ 2,303,439 $ 1,982,682
Product royalty revenues        
Revenues:        
Total revenues 130,828 110,293 373,869 350,253
Milestone and contract revenues        
Revenues:        
Total revenues $ 5,000 $ 0 $ 5,000 $ 135,000