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License Agreements - Novartis (Details) - USD ($)	1 Months Ended		3 Months Ended		9 Months Ended		167 Months Ended
	Sep. 30, 2023	Nov. 30, 2009	Sep. 30, 2023	Sep. 30, 2022	Sep. 30, 2023	Sep. 30, 2022	Sep. 30, 2023	Dec. 31, 2022
License Agreements
Total revenues			$ 919,025,000	$ 823,303,000	$ 2,682,308,000	$ 2,467,935,000
Product royalty revenues
License Agreements
Total revenues			130,828,000	110,293,000	373,869,000	350,253,000
JAKAFI
License Agreements
Total revenues			636,252,000	619,595,000	1,898,605,000	1,761,732,000
Milestone and contract revenues
License Agreements
Total revenues			5,000,000	0	5,000,000	135,000,000
Novartis
License Agreements
Royalties payable	$ 341,500,000		341,500,000		341,500,000		$ 341,500,000	$ 253,500,000
Novartis | JAKAVI | Non-US
License Agreements
Royalties payable on net sales			96,600,000	85,800,000	263,700,000	240,400,000
Novartis | JAKAFI | UNITED STATES
License Agreements
Royalties payable on net sales			31,100,000	30,300,000	88,000,000	81,300,000
Novartis | Milestone and contract revenues
License Agreements
Total revenues			5,000,000	0	5,000,000	60,000,000
Novartis | TABRECTA PROD SERV | Non-US
License Agreements
Royalties payable on net sales			$ 4,100,000	$ 4,100,000	$ 13,100,000	$ 11,200,000
Minimum | Novartis | JAKAVI
License Agreements
Royalty payments on future global net sales (as a percent)					12.00%
Maximum | Novartis | JAKAVI
License Agreements
Royalty payments on future global net sales (as a percent)					14.00%
Development Milestones | Novartis
License Agreements
Amount recognized and received for the achievement of a predefined milestone							157,000,000
Development Milestones | Maximum | Novartis
License Agreements
Upfront and immediate milestone payment to be received under license agreement		$ 174,000,000
Regulatory Milestones | Novartis
License Agreements
Amount recognized and received for the achievement of a predefined milestone	$ 5,000,000						345,000,000
Regulatory Milestones | Maximum | Novartis
License Agreements
Upfront and immediate milestone payment to be received under license agreement		495,000,000
Commercialization Milestones | Novartis
License Agreements
Amount recognized and received for the achievement of a predefined milestone							$ 200,000,000
Commercialization Milestones | Maximum | Novartis
License Agreements
Upfront and immediate milestone payment to be received under license agreement		500,000,000
Development and Regulatory Milestones | Maximum | Novartis
License Agreements
Upfront and immediate milestone payment to be received under license agreement		$ 75,000,000

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