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License Agreements - Agenus (Details) - USD ($)
 3 Months Ended 9 Months Ended 105 Months Ended
Sep. 30, 2023
Sep. 30, 2022
Sep. 30, 2023
Sep. 30, 2022
Sep. 30, 2023
May 31, 2023
Dec. 31, 2022
License Agreements              
Fair market long term investments $ 153,663,000   $ 153,663,000   $ 153,663,000   $ 133,676,000 [1]
Unrealized gain (loss) on long term investments $ (26,654,000) $ (660,000) $ 9,839,000 $ (72,142,000)      
Agenus              
License Agreements              
Common stock held from investment (in shares) 12,100,000   12,100,000   12,100,000    
Fair market long term investments $ 13,600,000   $ 13,600,000   $ 13,600,000   $ 29,000,000
Unrealized gain (loss) on long term investments (5,600,000) $ 1,300,000 (15,300,000) $ (14,100,000)      
MiNK              
License Agreements              
Fair market long term investments 200,000   200,000   200,000    
Unrealized gain (loss) on long term investments (200,000)   0        
Shares acquired due to distribution of dividend (in shares)           200,000  
Development, Regulatory and Commercialization Milestones | Agenus              
License Agreements              
Milestone payment made under license agreement         30,000,000    
Additional milestone payments under the license agreement $ 500,000,000   $ 500,000,000   $ 500,000,000    
[1] The condensed consolidated balance sheet at December 31, 2022 has been derived from the audited consolidated financial statements at that date.