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License Agreements - Syndax (Details) - USD ($) $ in Thousands	1 Months Ended		3 Months Ended		9 Months Ended
	Dec. 31, 2021	Sep. 30, 2021	Sep. 30, 2023	Sep. 30, 2022	Sep. 30, 2023	Sep. 30, 2022	Dec. 31, 2022
License Agreements
Fair market long term investments			$ 153,663		$ 153,663		$ 133,676	[1]
Unrealized gain (loss) on long term investments			(26,654)	$ (660)	9,839	$ (72,142)
Research and development			$ 375,709	384,007	$ 1,183,100	1,084,576
Investment in Syndax
License Agreements
Common stock held from investment (in shares)			1,400,000		1,400,000
Fair market long term investments			$ 20,600		$ 20,600		$ 36,200
Unrealized gain (loss) on long term investments			(9,200)	$ 6,800	(15,600)	$ 3,100
Syndax
License Agreements
Upfront payment under license agreement	$ 117,000
Research and development			5,100		16,900
Syndax | Accrued Liabilities
License Agreements
Accrued and other liabilities			7,300		7,300
Syndax | Development and Regulatory Milestones | Maximum
License Agreements
Additional milestone payments under the license agreement			220,000		220,000
Syndax | Commercialization Milestones | Maximum
License Agreements
Additional milestone payments under the license agreement			$ 230,000		$ 230,000
Syndax | Incyte
License Agreements
Funding of future development costs (as a percent)					55.00%
UNITED STATES | Syndax | Syndax
License Agreements
Funding of future development costs (as a percent)		45.00%
UNITED STATES | Syndax | Incyte
License Agreements
Funding of future development costs (as a percent)		55.00%
[1] The condensed consolidated balance sheet at December 31, 2022 has been derived from the audited consolidated financial statements at that date.

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