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License Agreements - Lily (Details) - USD ($) $ in Thousands | 1 Months Ended | 12 Months Ended | 94 Months Ended | 169 Months Ended |
--- | --- | --- | --- | --- | ---
Dec. 31, 2009 | Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2023 | Dec. 31, 2023 | Mar. 31, 2016
License agreements |  |  |  |  |  |  |
Total revenues |  | $ 3,695,649 | $ 3,394,635 | $ 2,986,267 |  |  |
Eli Lilly |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |
Total revenues |  | 0 | 70,000 | 50,000 |  |  |
Eli Lilly | OLUMIANT |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |
Total revenues |  | $ 136,100 | $ 134,500 | $ 220,900 |  |  |
Eli Lilly | GVHD |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |
Additional milestone payments under the license agreement |  |  |  |  |  |  | $ 40,000
Milestone payment made under license agreement |  |  |  |  | $ 40,000 |  |
Development Milestones | Eli Lilly |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  | $ 149,000 |
Development Milestones | Maximum | Eli Lilly |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement | $ 150,000 |  |  |  |  |  |
Regulatory Milestones | Eli Lilly |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  | 335,000 |
Regulatory Milestones | Maximum | Eli Lilly |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement | 365,000 |  |  |  |  |  |
Commercialization Milestones | Eli Lilly |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  | $ 50,000 |
Commercialization Milestones | Maximum | Eli Lilly |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement | $ 150,000 |  |  |  |  |  |

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