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License Agreements - Merus (Details) $ in Thousands | 1 Months Ended | 12 Months Ended | 85 Months Ended
--- | --- | --- | ---
Dec. 31, 2023 USD ($) shares | Aug. 31, 2023 USD ($) shares | Jan. 31, 2023 USD ($) | Dec. 31, 2016 USD ($) program | Dec. 31, 2023 USD ($) shares | Dec. 31, 2022 USD ($) | Dec. 31, 2021 USD ($) | Dec. 31, 2023 USD ($) shares
License agreements |  |  |  |  |  |  |  |
Long term investments | $ 187,716 |  |  |  | $ 187,716 | $ 133,676 |  | $ 187,716
Unrealized gain (loss) on long term investments |  |  |  |  | $ 43,893 | (87,590) | $ (24,072) |
Merus |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |
Purchase of common stock under Stock Purchase Agreement (in shares ) | shares |  | 500,000 |  |  |  |  |  |
Equity Method Investment, Aggregate Cost |  | $ 10,000 |  |  |  |  |  |
Investment owned (in shares) | shares | 4,000,000 |  |  |  | 4,000,000 |  |  | 4,000,000
Merus |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |
Long term investments | $ 110,100 |  |  |  | $ 110,100 | 54,900 |  | $ 110,100
Unrealized gain (loss) on long term investments |  |  |  |  | $ 45,200 | $ (58,000) | $ 48,100 |
Merus |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |
Number of independent programs | program |  |  |  | 10 |  |  |  |
Number of programs under the resulting products are co-funded for development | program |  |  |  | 2 |  |  |  |
Associated future global development costs from the initiation of a Phase IIb trial, if elected to co-develop |  |  |  | 35.00% |  |  |  |
Milestone payment made under license agreement |  |  |  |  |  |  |  | $ 9,000
Merus | United States |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |
Profit sharing |  |  |  | 50.00% |  |  |  |
Percentage of profit (losses) |  |  |  | 50.00% |  |  |  |
Merus | Minimum |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |
Royalty payments on future global net sales |  |  |  | 6.00% |  |  |  |
Merus | Minimum | United States |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |
Royalty payments on future global net sales |  |  |  | 6.00% |  |  |  |
Merus | Maximum |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |
Royalty payments on future global net sales |  |  |  | 10.00% |  |  |  |
Percentage of reverse royalty |  |  |  | 4.00% |  |  |  |
Merus | Maximum | United States |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |
Royalty payments on future global net sales |  |  |  | 10.00% |  |  |  |
Percentage of additional royalties |  |  |  | 4.00% |  |  |  |
Merus | Development and Regulatory Milestones | Maximum |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |
Additional milestone payments under the license agreement |  |  |  | $ 100,000 |  |  |  |
Merus | Commercialization Milestones | Maximum |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |
Additional milestone payments under the license agreement |  |  |  | $ 250,000 |  |  |  |
Merus |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |
Milestone payment made under license agreement | $ 1,000 | $ 2,500 | $ 2,500 |  |  |  |  |

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