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License Agreements - Syndax (Details) - USD ($) $ in Thousands, shares in Millions | 1 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2021 | Sep. 30, 2021 | Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
License agreements |  |  |  |  |
Long term investments |  |  | $ 187,716 | $ 133,676 |
Unrealized gain (loss) on long term investments |  |  | 43,893 | (87,590) | $ (24,072)
Research and development |  |  | $ 1,627,594 | 1,585,936 | 1,458,179
Investment in Syndax |  |  |  |  |
License agreements |  |  |  |  |
Investment owned (in shares) |  |  | 1.4 |  |
Long term investments |  |  | $ 30,700 | 36,200 |
Unrealized gain (loss) on long term investments |  |  | (5,500) | $ 5,100 |
Investment in Syndax |  |  |  |  |
License agreements |  |  |  |  |
Unrealized gain (loss) on long term investments |  |  |  |  | 6,300
Syndax |  |  |  |  |
License agreements |  |  |  |  |
Upfront payment under license agreement | $ 117,000 |  |  |  |
Research and development |  |  | 25,800 |  |
Syndax | Accrued Liabilities |  |  |  |  |
License agreements |  |  |  |  |
Accrued and other liabilities |  |  | $ 1,800 |  |
Syndax | Development and Regulatory Milestones | Maximum |  |  |  |  |
License agreements |  |  |  |  |
Additional milestone payments under the license agreement | 220,000 |  |  |  | 220,000
Syndax | Commercialization Milestones | Maximum |  |  |  |  |
License agreements |  |  |  |  |
Additional milestone payments under the license agreement | $ 230,000 |  |  |  | $ 230,000
Syndax | Incyte |  |  |  |  |
License agreements |  |  |  |  |
Funding of future development costs |  |  | 55.00% |  |
United States | Syndax | Syndax |  |  |  |  |
License agreements |  |  |  |  |
Funding of future development costs |  | 45.00% |  |  |
United States | Syndax | Incyte |  |  |  |  |
License agreements |  |  |  |  |
Funding of future development costs |  | 55.00% |  |  |

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