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CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($)
shares in Thousands, $ in Thousands
 12 Months Ended
Dec. 31, 2023
Dec. 31, 2022
Dec. 31, 2021
Revenues:      
Total revenues $ 3,695,649 $ 3,394,635 $ 2,986,267
Costs and expenses:      
Cost of product revenues (including definite-lived intangible amortization) 254,990 206,997 150,991
Research and development 1,627,594 1,585,936 1,458,179
Selling, general and administrative 1,161,293 1,002,140 739,560
Loss on change in fair value of acquisition-related contingent consideration 29,202 12,149 14,741
(Profit) and loss sharing under collaboration agreements 2,045 7,973 37,019
Total costs and expenses 3,075,124 2,815,195 2,400,490
Income from operations 620,525 579,440 585,777
Interest income and other, net 172,348 39,932 10,647
Interest expense (2,551) (2,666) (1,908)
Unrealized gain (loss) on long term investments 43,893 (87,590) (24,072)
Income before provision (benefit) for income taxes 834,215 529,116 570,444
Provision (benefit) for income taxes 236,616 188,456 (378,137)
Net income $ 597,599 $ 340,660 $ 948,581
Net income per share:      
Basic (in dollars per share) $ 2.67 $ 1.53 $ 4.30
Diluted (in dollars per share) $ 2.65 $ 1.52 $ 4.27
Shares used in computing net income per share:      
Basic (in shares) 223,628 222,004 220,428
Diluted (in shares) 225,928 223,958 222,074
Product revenues, net      
Revenues:      
Total revenues $ 3,165,168 $ 2,746,897 $ 2,322,012
Product royalty revenues      
Revenues:      
Total revenues 523,481 482,738 569,255
Milestone and contract revenues      
Revenues:      
Total revenues $ 7,000 $ 165,000 $ 95,000