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License Agreements - Novartis (Details) - USD ($) $ in Thousands	1 Months Ended		12 Months Ended			170 Months Ended
	Sep. 30, 2023	Nov. 30, 2009	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2023
License agreements
Revenues			$ 3,695,649	$ 3,394,635	$ 2,986,267
United States
License agreements
Revenues			3,500,000	3,200,000	2,900,000
JAKAFI
License agreements
Revenues			2,593,732	2,409,225	2,134,508
Novartis
License agreements
Revenues			5,000	60,000	0
Novartis | Development Milestones
License agreements
Amount recognized and received for the achievement of a predefined milestone						$ 157,000
Novartis | Development Milestones | Maximum
License agreements
Upfront and immediate milestone payment to be received under license agreement		$ 174,000
Novartis | Regulatory Milestones
License agreements
Amount recognized and received for the achievement of a predefined milestone	$ 5,000					345,000
Novartis | Regulatory Milestones | Maximum
License agreements
Upfront and immediate milestone payment to be received under license agreement		495,000
Novartis | Commercialization Milestones
License agreements
Amount recognized and received for the achievement of a predefined milestone						200,000
Novartis | Commercialization Milestones | Maximum
License agreements
Upfront and immediate milestone payment to be received under license agreement		500,000
Novartis | GVHD | Development and Regulatory Milestones | Maximum
License agreements
Upfront and immediate milestone payment to be received under license agreement		$ 75,000
Novartis | JAKAVI
License agreements
Revenues			$ 367,600	331,600	338,000
Novartis | JAKAVI | Minimum
License agreements
Royalty payments on future global net sales			12.00%
Novartis | JAKAVI | Maximum
License agreements
Royalty payments on future global net sales			14.00%
Novartis | JAKAFI | United States
License agreements
Revenues			$ 122,100	113,100	99,600
Royalties payable			375,600	253,500		$ 375,600
Novartis | TABRECTA
License agreements
Revenues			$ 17,800	$ 15,400	$ 10,400

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