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License Agreements - Lily (Details) - USD ($) $ in Thousands	1 Months Ended	12 Months Ended			94 Months Ended	169 Months Ended
	Dec. 31, 2009	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2023	Dec. 31, 2023	Mar. 31, 2016
License agreements
Total revenues		$ 3,695,649	$ 3,394,635	$ 2,986,267
Eli Lilly
License agreements
Total revenues		0	70,000	50,000
Eli Lilly | OLUMIANT
License agreements
Total revenues		$ 136,100	$ 134,500	$ 220,900
Eli Lilly | GVHD
License agreements
Additional milestone payments under the license agreement							$ 40,000
Milestone payment made under license agreement					$ 40,000
Development Milestones | Eli Lilly
License agreements
Amount recognized and received for the achievement of a predefined milestone						$ 149,000
Development Milestones | Maximum | Eli Lilly
License agreements
Upfront and immediate milestone payment to be received under license agreement	$ 150,000
Regulatory Milestones | Eli Lilly
License agreements
Amount recognized and received for the achievement of a predefined milestone						335,000
Regulatory Milestones | Maximum | Eli Lilly
License agreements
Upfront and immediate milestone payment to be received under license agreement	365,000
Commercialization Milestones | Eli Lilly
License agreements
Amount recognized and received for the achievement of a predefined milestone						$ 50,000
Commercialization Milestones | Maximum | Eli Lilly
License agreements
Upfront and immediate milestone payment to be received under license agreement	$ 150,000

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