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License Agreements - Syndax (Details) - USD ($)
$ in Thousands, shares in Millions
1 Months Ended 12 Months Ended
Dec. 31, 2021
Sep. 30, 2021
Dec. 31, 2023
Dec. 31, 2022
Dec. 31, 2021
License agreements          
Long term investments     $ 187,716 $ 133,676  
Unrealized gain (loss) on long term investments     43,893 (87,590) $ (24,072)
Research and development     $ 1,627,594 1,585,936 1,458,179
Investment in Syndax          
License agreements          
Investment owned (in shares)     1.4    
Long term investments     $ 30,700 36,200  
Unrealized gain (loss) on long term investments     (5,500) $ 5,100  
Investment in Syndax          
License agreements          
Unrealized gain (loss) on long term investments         6,300
Syndax          
License agreements          
Upfront payment under license agreement $ 117,000        
Research and development     25,800    
Syndax | Accrued Liabilities          
License agreements          
Accrued and other liabilities     $ 1,800    
Syndax | Development and Regulatory Milestones | Maximum          
License agreements          
Additional milestone payments under the license agreement 220,000       220,000
Syndax | Commercialization Milestones | Maximum          
License agreements          
Additional milestone payments under the license agreement $ 230,000       $ 230,000
Syndax | Incyte          
License agreements          
Funding of future development costs     55.00%    
United States | Syndax | Syndax          
License agreements          
Funding of future development costs   45.00%      
United States | Syndax | Incyte          
License agreements          
Funding of future development costs   55.00%