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Income Taxes - Reconciliation of income taxes (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2023
Dec. 31, 2022
Dec. 31, 2021
Reconciliation of income taxes at the U.S. federal statutory rate to the provision for income taxes      
Provision at U.S. federal statutory rate $ 175,185 $ 111,114 $ 119,793
State and local income taxes 21,145 26,767 34,461
Foreign tax rate differential (96,434) 13,670 55,171
Income tax credits (1,433,507) (30,505) (55,139)
Change in valuation allowance 1,572,951 67,056 (523,279)
Foreign-derived intangible income (32,891) (36,748) (28,259)
Stock based compensation 20,971 19,704 15,497
Acquisitions accounted for as research and development expenses 4,200 14,700 0
Other 4,996 2,698 3,618
Total provision (benefit) for income taxes 236,616 188,456 $ (378,137)
Deferred tax assets:      
Net operating loss carry forwards 326,446 182,193  
Income tax credits 1,441,981 17,141  
Capitalized research and development 457,603 265,140  
Deferred revenue and accruals 130,291 72,657  
Non-cash compensation 96,469 83,138  
Acquisition-related contingent consideration 30,298 30,483  
Intangibles, net 233,311 257,614  
Long term investments 42,975 54,662  
Other 9,044 9,600  
Total gross deferred tax assets 2,768,418 972,628  
Less valuation allowance for deferred tax assets (2,096,318) (472,125)  
Net deferred tax assets 672,100 500,503  
Deferred tax liabilities:      
Property and equipment (34,757) (33,683)  
Other (5,457) (8,879)  
Total gross deferred tax liabilities (40,214) (42,562)  
Net deferred tax assets $ 631,886 $ 457,941