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License Agreements - Syndax (Details) - USD ($) $ in Thousands | 1 Months Ended | 3 Months Ended | 31 Months Ended |
--- | --- | --- | --- | ---
Sep. 30, 2021 | Mar. 31, 2024 | Mar. 31, 2023 | Mar. 31, 2024 | Dec. 31, 2023
License Agreements |  |  |  |  |  |
Long term investments |  | $ 287,663 |  | $ 287,663 | $ 187,716 | [1]
Unrealized gain (loss) on long term investments |  | 99,947 | $ (5,318) |  |  |
Research and development |  | $ 429,260 | 406,641 |  |  |
Investment in Syndax |  |  |  |  |  |
License Agreements |  |  |  |  |  |
Common stock held from investment (in shares) |  | 1,400,000 |  | 1,400,000 |  |
Long term investments |  | $ 33,800 |  | $ 33,800 | 30,700 |
Unrealized gain (loss) on long term investments |  | 3,100 | $ (6,200) |  |  |
Syndax |  |  |  |  |  |
License Agreements |  |  |  |  |  |
Upfront payment under license agreement |  |  |  | 117,000 |  |
Research and development |  | 7,100 |  |  |  |
Syndax | UNITED STATES | Syndax |  |  |  |  |  |
License Agreements |  |  |  |  |  |
Funding of future development costs (as a percent) | 45.00% |  |  |  |  |
Syndax | Accrued Liabilities |  |  |  |  |  |
License Agreements |  |  |  |  |  |
Accrued and other liabilities |  | $ 1,900 |  | 1,900 | $ 1,800 |
Syndax | Incyte |  |  |  |  |  |
License Agreements |  |  |  |  |  |
Funding of future development costs (as a percent) |  | 55.00% |  |  |  |
Syndax | Incyte | UNITED STATES |  |  |  |  |  |
License Agreements |  |  |  |  |  |
Funding of future development costs (as a percent) | 55.00% |  |  |  |  |
Syndax | Development and Regulatory Milestones | Maximum |  |  |  |  |  |
License Agreements |  |  |  |  |  |
Additional milestone payments under the license agreement |  | $ 220,000 |  | 220,000 |  |
Syndax | Commercialization Milestones | Maximum |  |  |  |  |  |
License Agreements |  |  |  |  |  |
Additional milestone payments under the license agreement |  | $ 230,000 |  | $ 230,000 |  |
[1] | The condensed consolidated balance sheet at December 31, 2023 has been derived from the audited consolidated financial statements at that date.

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