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CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended
Mar. 31, 2024
Mar. 31, 2023
Revenues:    
Total revenues $ 880,889 $ 808,673
Costs, expenses and other:    
Cost of product revenues (including definite-lived intangible amortization) 60,956 56,822
Research and development 429,260 406,641
Selling, general and administrative 300,256 315,606
(Gain) loss on change in fair value of acquisition-related contingent consideration (456) 6,196
(Profit) and loss sharing under collaboration agreements (1,025) (1,362)
Total costs, expenses and other 788,991 783,903
Income from operations 91,898 24,770
Interest income and other, net 44,744 32,873
Interest expense (430) (469)
Unrealized gain (loss) on long term investments 99,947 (5,318)
Income before provision for income taxes 236,159 51,856
Provision for income taxes 66,611 30,153
Net income $ 169,548 $ 21,703
Net income per share:    
Basic (in USD per share) $ 0.76 $ 0.10
Diluted (in USD per share) $ 0.75 $ 0.10
Shares used in computing net income per share:    
Basic (in shares) 224,484 222,960
Diluted (in shares) 227,219 225,589
Product revenues, net    
Revenues:    
Total revenues $ 729,923 $ 693,237
Product royalty revenues    
Revenues:    
Total revenues 125,966 115,436
Milestone and contract revenues    
Revenues:    
Total revenues $ 25,000 $ 0