<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2024 Workiva-->
<!--r:3d236890-e000-4be1-853f-099b89625e19,g:0daae2a8-57e4-4e4c-af65-0fc9c4a6c633-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.incyte.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETS" xlink:type="simple" xlink:href="incy-20240630.xsd#CONDENSEDCONSOLIDATEDBALANCESHEETS"/>
  <link:calculationLink xlink:role="http://www.incyte.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_8974389c-65d9-4b5b-aa6a-3d31630b28d8" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_cfacd1dc-11b2-4ddd-a9b7-20531c67e36d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_8974389c-65d9-4b5b-aa6a-3d31630b28d8" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_cfacd1dc-11b2-4ddd-a9b7-20531c67e36d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_d15f7ea4-6cc8-4c10-9404-72a9cd6601ae" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_8974389c-65d9-4b5b-aa6a-3d31630b28d8" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_d15f7ea4-6cc8-4c10-9404-72a9cd6601ae" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNet_21828e83-f054-4e3d-bde4-8dc6cd44c912" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccountsReceivableNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_8974389c-65d9-4b5b-aa6a-3d31630b28d8" xlink:to="loc_us-gaap_AccountsReceivableNet_21828e83-f054-4e3d-bde4-8dc6cd44c912" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_e5d93c62-1ef8-495e-adb3-5c7935c4a92a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_8974389c-65d9-4b5b-aa6a-3d31630b28d8" xlink:to="loc_us-gaap_InventoryNet_e5d93c62-1ef8-495e-adb3-5c7935c4a92a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_02b2f002-b1a0-49f9-a9c4-fc893d3a2e3b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_8974389c-65d9-4b5b-aa6a-3d31630b28d8" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_02b2f002-b1a0-49f9-a9c4-fc893d3a2e3b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNi_53559b60-9a13-4dbf-9db2-f58b21a22d3e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EquitySecuritiesFvNi"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_8974389c-65d9-4b5b-aa6a-3d31630b28d8" xlink:to="loc_us-gaap_EquitySecuritiesFvNi_53559b60-9a13-4dbf-9db2-f58b21a22d3e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_c6b4ad33-8c9d-4e98-8f94-4b1553a88c4f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_5785317f-bad0-42f8-8cc2-82b4888f50c4" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_c6b4ad33-8c9d-4e98-8f94-4b1553a88c4f" xlink:to="loc_us-gaap_Liabilities_5785317f-bad0-42f8-8cc2-82b4888f50c4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_6f116a2a-5925-4acd-8e2d-7998d590fd44" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_c6b4ad33-8c9d-4e98-8f94-4b1553a88c4f" xlink:to="loc_us-gaap_StockholdersEquity_6f116a2a-5925-4acd-8e2d-7998d590fd44" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_1f0d00fe-58df-4f83-9e85-77b503a85f42" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_c6b4ad33-8c9d-4e98-8f94-4b1553a88c4f" xlink:to="loc_us-gaap_CommitmentsAndContingencies_1f0d00fe-58df-4f83-9e85-77b503a85f42" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_b0957606-0383-4c6d-90b2-857f422d69a4" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_a01edca7-4e4e-481a-b2f3-3cb4bc257691" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_b0957606-0383-4c6d-90b2-857f422d69a4" xlink:to="loc_us-gaap_AssetsCurrent_a01edca7-4e4e-481a-b2f3-3cb4bc257691" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashNoncurrent_6aff759d-3804-442f-a880-eaf29db017d5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RestrictedCashNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_b0957606-0383-4c6d-90b2-857f422d69a4" xlink:to="loc_us-gaap_RestrictedCashNoncurrent_6aff759d-3804-442f-a880-eaf29db017d5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFVNINoncurrent_37ea1e00-543b-4c91-a3e0-d6fa5a4e9f81" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EquitySecuritiesFVNINoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_b0957606-0383-4c6d-90b2-857f422d69a4" xlink:to="loc_us-gaap_EquitySecuritiesFVNINoncurrent_37ea1e00-543b-4c91-a3e0-d6fa5a4e9f81" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNoncurrent_33667df3-fb60-47fe-8c71-35d681e536ef" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InventoryNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_b0957606-0383-4c6d-90b2-857f422d69a4" xlink:to="loc_us-gaap_InventoryNoncurrent_33667df3-fb60-47fe-8c71-35d681e536ef" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_0396ba39-2e2d-4c7d-96ef-0eb33cf4e6b2" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_b0957606-0383-4c6d-90b2-857f422d69a4" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_0396ba39-2e2d-4c7d-96ef-0eb33cf4e6b2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseRightOfUseAsset_6811f1ed-12a0-4388-97fc-e98b13d5e7fb" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FinanceLeaseRightOfUseAsset"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_b0957606-0383-4c6d-90b2-857f422d69a4" xlink:to="loc_us-gaap_FinanceLeaseRightOfUseAsset_6811f1ed-12a0-4388-97fc-e98b13d5e7fb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherIntangibleAssetsNet_965d20a2-ca7f-4a1c-a166-0b4e185fbc1c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherIntangibleAssetsNet"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_b0957606-0383-4c6d-90b2-857f422d69a4" xlink:to="loc_us-gaap_OtherIntangibleAssetsNet_965d20a2-ca7f-4a1c-a166-0b4e185fbc1c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_70469f71-8a74-488a-84d2-5955db26d848" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_b0957606-0383-4c6d-90b2-857f422d69a4" xlink:to="loc_us-gaap_Goodwill_70469f71-8a74-488a-84d2-5955db26d848" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxAssetsNet_d17cf0fc-b290-4af7-958d-ba6ccb616e65" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DeferredIncomeTaxAssetsNet"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_b0957606-0383-4c6d-90b2-857f422d69a4" xlink:to="loc_us-gaap_DeferredIncomeTaxAssetsNet_d17cf0fc-b290-4af7-958d-ba6ccb616e65" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_2186c861-a5f0-4a78-b187-46f9f745ab53" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_b0957606-0383-4c6d-90b2-857f422d69a4" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_2186c861-a5f0-4a78-b187-46f9f745ab53" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_dc23b47d-03d7-41fc-9a8d-5bd677ae3636" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_4eca7f76-89fd-4698-bcfe-61b780c6dbdc" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_dc23b47d-03d7-41fc-9a8d-5bd677ae3636" xlink:to="loc_us-gaap_PreferredStockValue_4eca7f76-89fd-4698-bcfe-61b780c6dbdc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_1264ca82-6a35-441f-ae39-6c719ce4528d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_dc23b47d-03d7-41fc-9a8d-5bd677ae3636" xlink:to="loc_us-gaap_CommonStockValue_1264ca82-6a35-441f-ae39-6c719ce4528d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalCommonStock_20fecdc9-696d-4b65-b6cb-2c5747f3a541" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AdditionalPaidInCapitalCommonStock"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_dc23b47d-03d7-41fc-9a8d-5bd677ae3636" xlink:to="loc_us-gaap_AdditionalPaidInCapitalCommonStock_20fecdc9-696d-4b65-b6cb-2c5747f3a541" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_2ca0d7c8-ad70-47fd-9675-6665c5abcb46" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_dc23b47d-03d7-41fc-9a8d-5bd677ae3636" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_2ca0d7c8-ad70-47fd-9675-6665c5abcb46" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_5ccc6204-f5f7-4284-8317-4138d63f36f1" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_dc23b47d-03d7-41fc-9a8d-5bd677ae3636" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_5ccc6204-f5f7-4284-8317-4138d63f36f1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_932ccedc-1537-4acb-93a2-efeaf06f66f4" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_0c094977-1d6f-41be-b5a2-d5767459406a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_932ccedc-1537-4acb-93a2-efeaf06f66f4" xlink:to="loc_us-gaap_AccountsPayableCurrent_0c094977-1d6f-41be-b5a2-d5767459406a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_c6d97574-a6ff-4c16-aee9-f754e58f5103" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_932ccedc-1537-4acb-93a2-efeaf06f66f4" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_c6d97574-a6ff-4c16-aee9-f754e58f5103" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_5064fb49-38b4-4067-bd39-95b547a13451" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_932ccedc-1537-4acb-93a2-efeaf06f66f4" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_5064fb49-38b4-4067-bd39-95b547a13451" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityCurrent_47d3ed41-dd28-4a05-ae8e-32017ddae0dd" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FinanceLeaseLiabilityCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_932ccedc-1537-4acb-93a2-efeaf06f66f4" xlink:to="loc_us-gaap_FinanceLeaseLiabilityCurrent_47d3ed41-dd28-4a05-ae8e-32017ddae0dd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_585badb8-5899-4206-aaec-9e231eb24fe8" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_932ccedc-1537-4acb-93a2-efeaf06f66f4" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_585badb8-5899-4206-aaec-9e231eb24fe8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_26c85019-a9b3-4159-9efc-cc9f9b2c325d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_b5cd27c1-404b-4485-b800-72bba442aabe" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_26c85019-a9b3-4159-9efc-cc9f9b2c325d" xlink:to="loc_us-gaap_LiabilitiesCurrent_b5cd27c1-404b-4485-b800-72bba442aabe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_716425c1-9c39-4b1a-92b7-5d42b742cf1b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_26c85019-a9b3-4159-9efc-cc9f9b2c325d" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_716425c1-9c39-4b1a-92b7-5d42b742cf1b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_6cf52231-1b22-4255-9c10-8a76d22f3750" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FinanceLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_26c85019-a9b3-4159-9efc-cc9f9b2c325d" xlink:to="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_6cf52231-1b22-4255-9c10-8a76d22f3750" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_83190200-e31c-4225-a682-88df39322086" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_26c85019-a9b3-4159-9efc-cc9f9b2c325d" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_83190200-e31c-4225-a682-88df39322086" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.incyte.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONS" xlink:type="simple" xlink:href="incy-20240630.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONS"/>
  <link:calculationLink xlink:role="http://www.incyte.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_47a726e3-1959-418a-8865-daf2c299d3b2" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_66e0ef90-c88c-46bd-b8c7-de13a0742460" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_47a726e3-1959-418a-8865-daf2c299d3b2" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_66e0ef90-c88c-46bd-b8c7-de13a0742460" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_0ada7d81-8dac-4e95-9167-560a3d99838d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CostsAndExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_47a726e3-1959-418a-8865-daf2c299d3b2" xlink:to="loc_us-gaap_CostsAndExpenses_0ada7d81-8dac-4e95-9167-560a3d99838d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_779929e7-7bd7-438e-b008-13f5da70ce25" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CostsAndExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfRevenue_06d60ebb-b71e-4ff3-a4f4-8944ce9bb5f2" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CostOfRevenue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_779929e7-7bd7-438e-b008-13f5da70ce25" xlink:to="loc_us-gaap_CostOfRevenue_06d60ebb-b71e-4ff3-a4f4-8944ce9bb5f2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_da3925e0-6ac1-4a0d-942a-1da1ff7399c8" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_779929e7-7bd7-438e-b008-13f5da70ce25" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_da3925e0-6ac1-4a0d-942a-1da1ff7399c8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_e8ddf9d5-7b0d-481a-b9e8-10a6973742c6" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_779929e7-7bd7-438e-b008-13f5da70ce25" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_e8ddf9d5-7b0d-481a-b9e8-10a6973742c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_f1ff2526-b630-4235-8d57-22e8234d8ca9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_779929e7-7bd7-438e-b008-13f5da70ce25" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_f1ff2526-b630-4235-8d57-22e8234d8ca9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_incy_CollaborationLossProfitSharingExpense_e3cb1e64-b3e0-4bdc-80b5-e05743af1ae4" xlink:href="incy-20240630.xsd#incy_CollaborationLossProfitSharingExpense"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_779929e7-7bd7-438e-b008-13f5da70ce25" xlink:to="loc_incy_CollaborationLossProfitSharingExpense_e3cb1e64-b3e0-4bdc-80b5-e05743af1ae4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_39b25cd5-e3d8-4257-a41a-d766f68b721d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_0ee1ef22-75f5-44d4-82c7-3399bd750700" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_39b25cd5-e3d8-4257-a41a-d766f68b721d" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_0ee1ef22-75f5-44d4-82c7-3399bd750700" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_6accacfa-0108-49da-ae0e-bc083b028e26" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_39b25cd5-e3d8-4257-a41a-d766f68b721d" xlink:to="loc_us-gaap_OperatingIncomeLoss_6accacfa-0108-49da-ae0e-bc083b028e26" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseNonoperating_096c903a-2cb2-463f-8629-59b40677f2d5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InterestExpenseNonoperating"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_39b25cd5-e3d8-4257-a41a-d766f68b721d" xlink:to="loc_us-gaap_InterestExpenseNonoperating_096c903a-2cb2-463f-8629-59b40677f2d5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiGainLoss_3b1c9efb-6af7-479f-a183-592878032659" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EquitySecuritiesFvNiGainLoss"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_39b25cd5-e3d8-4257-a41a-d766f68b721d" xlink:to="loc_us-gaap_EquitySecuritiesFvNiGainLoss_3b1c9efb-6af7-479f-a183-592878032659" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_d9397b61-0bb6-4bc9-84e5-1b35891fb1ec" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_74d7a424-7919-4149-bc75-5a13b90285e2" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_d9397b61-0bb6-4bc9-84e5-1b35891fb1ec" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_74d7a424-7919-4149-bc75-5a13b90285e2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_036a0e60-7d7e-4312-9200-236641b2538a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_d9397b61-0bb6-4bc9-84e5-1b35891fb1ec" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_036a0e60-7d7e-4312-9200-236641b2538a" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.incyte.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS" xlink:type="simple" xlink:href="incy-20240630.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS"/>
  <link:calculationLink xlink:role="http://www.incyte.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_37b8acac-89fe-45a2-af32-37396b2f5e9e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_538d86db-b3c7-4a90-86a9-bfb2a1734b9d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_37b8acac-89fe-45a2-af32-37396b2f5e9e" xlink:to="loc_us-gaap_NetIncomeLoss_538d86db-b3c7-4a90-86a9-bfb2a1734b9d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_2efe2192-e0cb-4beb-8e09-050170ce8ed9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_37b8acac-89fe-45a2-af32-37396b2f5e9e" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_2efe2192-e0cb-4beb-8e09-050170ce8ed9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_3b7843f0-8e81-4bb9-9b77-a790af761461" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_98fd7561-4476-4edf-96ce-f826b6bc73ba" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_3b7843f0-8e81-4bb9-9b77-a790af761461" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_98fd7561-4476-4edf-96ce-f826b6bc73ba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_fb03ea6c-7b36-49f4-8ecb-63ba957b78fc" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_3b7843f0-8e81-4bb9-9b77-a790af761461" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_fb03ea6c-7b36-49f4-8ecb-63ba957b78fc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentNetOfTax_481aa92a-077b-4f9f-8796-8a442750e963" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentNetOfTax"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_3b7843f0-8e81-4bb9-9b77-a790af761461" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentNetOfTax_481aa92a-077b-4f9f-8796-8a442750e963" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.incyte.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="simple" xlink:href="incy-20240630.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS"/>
  <link:calculationLink xlink:role="http://www.incyte.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_e862d667-b025-4f82-be2c-c18c21d9d242" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockPlans_2d43b458-41f4-4d3b-ab16-87724ea078a6" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProceedsFromStockPlans"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_e862d667-b025-4f82-be2c-c18c21d9d242" xlink:to="loc_us-gaap_ProceedsFromStockPlans_2d43b458-41f4-4d3b-ab16-87724ea078a6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_8fe00c0b-7a16-4451-8290-986e29ae24d5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_e862d667-b025-4f82-be2c-c18c21d9d242" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_8fe00c0b-7a16-4451-8290-986e29ae24d5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeasePrincipalPayments_68822243-67d2-43f5-babf-9351f434b2ea" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FinanceLeasePrincipalPayments"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_e862d667-b025-4f82-be2c-c18c21d9d242" xlink:to="loc_us-gaap_FinanceLeasePrincipalPayments_68822243-67d2-43f5-babf-9351f434b2ea" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_incy_PaymentOfContingentConsideration_9c169886-dc2a-4df8-a8d1-06fa2e1bb009" xlink:href="incy-20240630.xsd#incy_PaymentOfContingentConsideration"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_e862d667-b025-4f82-be2c-c18c21d9d242" xlink:to="loc_incy_PaymentOfContingentConsideration_9c169886-dc2a-4df8-a8d1-06fa2e1bb009" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_e77cc2c8-076a-4432-9946-a411bc9eb5e9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_e862d667-b025-4f82-be2c-c18c21d9d242" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_e77cc2c8-076a-4432-9946-a411bc9eb5e9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_70d5590a-c1c3-4b8f-9d6b-bd4a14d59915" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1a15ba8f-c4a4-4797-97c3-2f32d5ec4219" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_70d5590a-c1c3-4b8f-9d6b-bd4a14d59915" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1a15ba8f-c4a4-4797-97c3-2f32d5ec4219" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_1e9ac177-929d-4692-b5ed-84c5b0a2d638" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_70d5590a-c1c3-4b8f-9d6b-bd4a14d59915" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_1e9ac177-929d-4692-b5ed-84c5b0a2d638" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_b748bcc7-6340-4081-aff9-02986d306a54" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_70d5590a-c1c3-4b8f-9d6b-bd4a14d59915" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_b748bcc7-6340-4081-aff9-02986d306a54" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_92f7315d-3ad2-43dc-8e78-ea3a47c5c611" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_70d5590a-c1c3-4b8f-9d6b-bd4a14d59915" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_92f7315d-3ad2-43dc-8e78-ea3a47c5c611" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a4ce4d4c-cdd6-4eb4-a7b1-ab1cf861a897" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_c8ae6d77-2059-4eb8-b705-95602112938d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a4ce4d4c-cdd6-4eb4-a7b1-ab1cf861a897" xlink:to="loc_us-gaap_ProfitLoss_c8ae6d77-2059-4eb8-b705-95602112938d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_f4766e6c-ee39-4370-83ad-4fe1bfadad84" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a4ce4d4c-cdd6-4eb4-a7b1-ab1cf861a897" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_f4766e6c-ee39-4370-83ad-4fe1bfadad84" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_86c2cf55-382e-44d1-a982-b3973d0a1f89" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a4ce4d4c-cdd6-4eb4-a7b1-ab1cf861a897" xlink:to="loc_us-gaap_ShareBasedCompensation_86c2cf55-382e-44d1-a982-b3973d0a1f89" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_ebe21893-a6d1-470c-b87b-9929545fe001" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInDeferredIncomeTaxes"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a4ce4d4c-cdd6-4eb4-a7b1-ab1cf861a897" xlink:to="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_ebe21893-a6d1-470c-b87b-9929545fe001" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncashIncomeExpense_64427701-c258-4832-b0ac-aa7e2bb944d6" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherNoncashIncomeExpense"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a4ce4d4c-cdd6-4eb4-a7b1-ab1cf861a897" xlink:to="loc_us-gaap_OtherNoncashIncomeExpense_64427701-c258-4832-b0ac-aa7e2bb944d6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiGainLoss_080f25e9-d630-4b0b-b086-f670d7d4ee63" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EquitySecuritiesFvNiGainLoss"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a4ce4d4c-cdd6-4eb4-a7b1-ab1cf861a897" xlink:to="loc_us-gaap_EquitySecuritiesFvNiGainLoss_080f25e9-d630-4b0b-b086-f670d7d4ee63" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_92f5e6fd-2f19-4bf5-94cb-33359491fe79" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a4ce4d4c-cdd6-4eb4-a7b1-ab1cf861a897" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_92f5e6fd-2f19-4bf5-94cb-33359491fe79" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_b7886e20-8ea3-473a-afac-902ef7c4e3bb" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a4ce4d4c-cdd6-4eb4-a7b1-ab1cf861a897" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_b7886e20-8ea3-473a-afac-902ef7c4e3bb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_c758113e-365f-4187-8ce9-54b09408a19f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a4ce4d4c-cdd6-4eb4-a7b1-ab1cf861a897" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_c758113e-365f-4187-8ce9-54b09408a19f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_2955d15f-b5eb-4af0-8e88-826c6e40e96a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a4ce4d4c-cdd6-4eb4-a7b1-ab1cf861a897" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_2955d15f-b5eb-4af0-8e88-826c6e40e96a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_d104b1a4-ef11-45c3-987d-1bd8e9cbbfa5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a4ce4d4c-cdd6-4eb4-a7b1-ab1cf861a897" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_d104b1a4-ef11-45c3-987d-1bd8e9cbbfa5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_4619db51-abfb-4b4e-8474-e9626cea3470" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a4ce4d4c-cdd6-4eb4-a7b1-ab1cf861a897" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_4619db51-abfb-4b4e-8474-e9626cea3470" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_afd7b9c6-3355-408f-bc00-2d75e1dd1fac" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireIntangibleAssets_a2787d1c-c44e-4030-ae0a-bf8424e7b39c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PaymentsToAcquireIntangibleAssets"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_afd7b9c6-3355-408f-bc00-2d75e1dd1fac" xlink:to="loc_us-gaap_PaymentsToAcquireIntangibleAssets_a2787d1c-c44e-4030-ae0a-bf8424e7b39c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireMarketableSecurities_7b79d2d9-5ca8-4580-adac-f5b8e73339d7" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PaymentsToAcquireMarketableSecurities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_afd7b9c6-3355-408f-bc00-2d75e1dd1fac" xlink:to="loc_us-gaap_PaymentsToAcquireMarketableSecurities_7b79d2d9-5ca8-4580-adac-f5b8e73339d7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_745f3bdb-d468-410e-b6d7-f37f0dfcc99d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_afd7b9c6-3355-408f-bc00-2d75e1dd1fac" xlink:to="loc_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_745f3bdb-d468-410e-b6d7-f37f0dfcc99d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfLongtermInvestments_2879bddd-53f9-4b65-97b7-ae65f5e0da89" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProceedsFromSaleOfLongtermInvestments"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_afd7b9c6-3355-408f-bc00-2d75e1dd1fac" xlink:to="loc_us-gaap_ProceedsFromSaleOfLongtermInvestments_2879bddd-53f9-4b65-97b7-ae65f5e0da89" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireOtherProductiveAssets_338f894e-8f3e-4abc-8f23-e69f809c60cd" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PaymentsToAcquireOtherProductiveAssets"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_afd7b9c6-3355-408f-bc00-2d75e1dd1fac" xlink:to="loc_us-gaap_PaymentsToAcquireOtherProductiveAssets_338f894e-8f3e-4abc-8f23-e69f809c60cd" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.incyte.com/role/FairValueofFinancialInstrumentsScheduleofMarketableSecuritiesPortfolioDetails" xlink:type="simple" xlink:href="incy-20240630.xsd#FairValueofFinancialInstrumentsScheduleofMarketableSecuritiesPortfolioDetails"/>
  <link:calculationLink xlink:role="http://www.incyte.com/role/FairValueofFinancialInstrumentsScheduleofMarketableSecuritiesPortfolioDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLoss_58abff35-0ca7-4ba1-8ce7-176e23c5b384" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_6c9159e3-a913-48cd-98cb-b5870d509718" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLoss_58abff35-0ca7-4ba1-8ce7-176e23c5b384" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_6c9159e3-a913-48cd-98cb-b5870d509718" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedGainLossBeforeTax_77ee2676-dfad-4185-8b4f-cd7ceee822e5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedGainLossBeforeTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLoss_58abff35-0ca7-4ba1-8ce7-176e23c5b384" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedGainLossBeforeTax_77ee2676-dfad-4185-8b4f-cd7ceee822e5" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.incyte.com/role/FairValueofFinancialInstrumentsScheduleofAssetsMeasuredonaRecurringBasisDetails" xlink:type="simple" xlink:href="incy-20240630.xsd#FairValueofFinancialInstrumentsScheduleofAssetsMeasuredonaRecurringBasisDetails"/>
  <link:calculationLink xlink:role="http://www.incyte.com/role/FairValueofFinancialInstrumentsScheduleofAssetsMeasuredonaRecurringBasisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_b686c0a9-4629-461d-8847-0612eea2a357" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_8c2475f0-50c7-4ba5-a00b-af88c562de90" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_b686c0a9-4629-461d-8847-0612eea2a357" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_8c2475f0-50c7-4ba5-a00b-af88c562de90" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_6123389e-1352-4762-93f6-ad6e2c7c4cf1" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_b686c0a9-4629-461d-8847-0612eea2a357" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_6123389e-1352-4762-93f6-ad6e2c7c4cf1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNi_a9ce6db3-90e1-4dce-a7f5-f2aaf60082c0" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EquitySecuritiesFvNi"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_b686c0a9-4629-461d-8847-0612eea2a357" xlink:to="loc_us-gaap_EquitySecuritiesFvNi_a9ce6db3-90e1-4dce-a7f5-f2aaf60082c0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFVNINoncurrent_5bd39158-781e-40b4-b2d6-338e02955ec1" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EquitySecuritiesFVNINoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_b686c0a9-4629-461d-8847-0612eea2a357" xlink:to="loc_us-gaap_EquitySecuritiesFVNINoncurrent_5bd39158-781e-40b4-b2d6-338e02955ec1" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.incyte.com/role/FairValueofFinancialInstrumentsScheduleofLiabilitiesMeasuredonaRecurringBasisDetails" xlink:type="simple" xlink:href="incy-20240630.xsd#FairValueofFinancialInstrumentsScheduleofLiabilitiesMeasuredonaRecurringBasisDetails"/>
  <link:calculationLink xlink:role="http://www.incyte.com/role/FairValueofFinancialInstrumentsScheduleofLiabilitiesMeasuredonaRecurringBasisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialLiabilitiesFairValueDisclosure_b670a0cb-8ada-418a-bb0a-e10b0065cda6" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FinancialLiabilitiesFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_52fc027e-768a-4170-9ce6-efa3a3e02f06" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationContingentConsiderationLiability"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinancialLiabilitiesFairValueDisclosure_b670a0cb-8ada-418a-bb0a-e10b0065cda6" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_52fc027e-768a-4170-9ce6-efa3a3e02f06" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.incyte.com/role/AcquisitionsScheduleofNetofCompensationExpenseAcrosstheNetAssetsAcquiredDetails" xlink:type="simple" xlink:href="incy-20240630.xsd#AcquisitionsScheduleofNetofCompensationExpenseAcrosstheNetAssetsAcquiredDetails"/>
  <link:calculationLink xlink:role="http://www.incyte.com/role/AcquisitionsScheduleofNetofCompensationExpenseAcrosstheNetAssetsAcquiredDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_incy_AssetAcquisitionAssetsAcquiredAndLiabilitiesAssumedNet_52857b53-2040-49eb-a963-34cd6a351d2f" xlink:href="incy-20240630.xsd#incy_AssetAcquisitionAssetsAcquiredAndLiabilitiesAssumedNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_incy_AssetAcquisitionAccountsPayableAndAccruedExpenses_827a1e01-f9d9-4756-9a3d-276e67172e72" xlink:href="incy-20240630.xsd#incy_AssetAcquisitionAccountsPayableAndAccruedExpenses"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_incy_AssetAcquisitionAssetsAcquiredAndLiabilitiesAssumedNet_52857b53-2040-49eb-a963-34cd6a351d2f" xlink:to="loc_incy_AssetAcquisitionAccountsPayableAndAccruedExpenses_827a1e01-f9d9-4756-9a3d-276e67172e72" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_incy_AssetAcquisitionNoncurrentLiabilities_9a618c01-dc6b-4afd-8f17-97754d18f226" xlink:href="incy-20240630.xsd#incy_AssetAcquisitionNoncurrentLiabilities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_incy_AssetAcquisitionAssetsAcquiredAndLiabilitiesAssumedNet_52857b53-2040-49eb-a963-34cd6a351d2f" xlink:to="loc_incy_AssetAcquisitionNoncurrentLiabilities_9a618c01-dc6b-4afd-8f17-97754d18f226" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_incy_AssetAcquisitionPrepaidExpensesAndOtherCurrentAssets_a64a3731-140d-419b-8ebc-95af3dba6e2e" xlink:href="incy-20240630.xsd#incy_AssetAcquisitionPrepaidExpensesAndOtherCurrentAssets"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_incy_AssetAcquisitionAssetsAcquiredAndLiabilitiesAssumedNet_52857b53-2040-49eb-a963-34cd6a351d2f" xlink:to="loc_incy_AssetAcquisitionPrepaidExpensesAndOtherCurrentAssets_a64a3731-140d-419b-8ebc-95af3dba6e2e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_incy_AssetAcquisitionOtherNonCurrentAssets_8482dc7b-1448-407e-9db2-b8656c7c1180" xlink:href="incy-20240630.xsd#incy_AssetAcquisitionOtherNonCurrentAssets"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_incy_AssetAcquisitionAssetsAcquiredAndLiabilitiesAssumedNet_52857b53-2040-49eb-a963-34cd6a351d2f" xlink:to="loc_incy_AssetAcquisitionOtherNonCurrentAssets_8482dc7b-1448-407e-9db2-b8656c7c1180" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_incy_AssetAcquisitionDeferredTaxAsset_9b682253-db42-4a9b-bc16-39e74514414e" xlink:href="incy-20240630.xsd#incy_AssetAcquisitionDeferredTaxAsset"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_incy_AssetAcquisitionAssetsAcquiredAndLiabilitiesAssumedNet_52857b53-2040-49eb-a963-34cd6a351d2f" xlink:to="loc_incy_AssetAcquisitionDeferredTaxAsset_9b682253-db42-4a9b-bc16-39e74514414e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_incy_AssetAcquisitionCashAndCashEquivalents_a5ed5253-a7ca-4271-b03e-dde3d8d0965c" xlink:href="incy-20240630.xsd#incy_AssetAcquisitionCashAndCashEquivalents"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_incy_AssetAcquisitionAssetsAcquiredAndLiabilitiesAssumedNet_52857b53-2040-49eb-a963-34cd6a351d2f" xlink:to="loc_incy_AssetAcquisitionCashAndCashEquivalents_a5ed5253-a7ca-4271-b03e-dde3d8d0965c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_incy_AssetAcquisitionOtherCurrentLiabilities_1cc07d09-5dcb-42a4-9f22-3517a35a2993" xlink:href="incy-20240630.xsd#incy_AssetAcquisitionOtherCurrentLiabilities"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_incy_AssetAcquisitionAssetsAcquiredAndLiabilitiesAssumedNet_52857b53-2040-49eb-a963-34cd6a351d2f" xlink:to="loc_incy_AssetAcquisitionOtherCurrentLiabilities_1cc07d09-5dcb-42a4-9f22-3517a35a2993" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefinitelivedIntangibleAssetsAcquired_979c4169-e2c9-4ee0-8657-0a9c12f2c57e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IndefinitelivedIntangibleAssetsAcquired"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_incy_AssetAcquisitionAssetsAcquiredAndLiabilitiesAssumedNet_52857b53-2040-49eb-a963-34cd6a351d2f" xlink:to="loc_us-gaap_IndefinitelivedIntangibleAssetsAcquired_979c4169-e2c9-4ee0-8657-0a9c12f2c57e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_incy_AssetAcquisitionMarketableSecurities_f177ca7c-1041-4247-8a3a-34e10e964ede" xlink:href="incy-20240630.xsd#incy_AssetAcquisitionMarketableSecurities"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_incy_AssetAcquisitionAssetsAcquiredAndLiabilitiesAssumedNet_52857b53-2040-49eb-a963-34cd6a351d2f" xlink:to="loc_incy_AssetAcquisitionMarketableSecurities_f177ca7c-1041-4247-8a3a-34e10e964ede" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.incyte.com/role/InventoryScheduleofInventoryBalancesDetails" xlink:type="simple" xlink:href="incy-20240630.xsd#InventoryScheduleofInventoryBalancesDetails"/>
  <link:calculationLink xlink:role="http://www.incyte.com/role/InventoryScheduleofInventoryBalancesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_incy_InventoryNetCurrentAndNoncurrent_b53113d2-6478-4e7e-9e9b-a6f4af79e595" xlink:href="incy-20240630.xsd#incy_InventoryNetCurrentAndNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterialsNetOfReserves_a3de6476-092c-4ed3-80df-76f974815c70" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InventoryRawMaterialsNetOfReserves"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_incy_InventoryNetCurrentAndNoncurrent_b53113d2-6478-4e7e-9e9b-a6f4af79e595" xlink:to="loc_us-gaap_InventoryRawMaterialsNetOfReserves_a3de6476-092c-4ed3-80df-76f974815c70" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcessNetOfReserves_a9914181-afcc-43da-a670-bd2352167fab" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InventoryWorkInProcessNetOfReserves"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_incy_InventoryNetCurrentAndNoncurrent_b53113d2-6478-4e7e-9e9b-a6f4af79e595" xlink:to="loc_us-gaap_InventoryWorkInProcessNetOfReserves_a9914181-afcc-43da-a670-bd2352167fab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_3354f626-4d4f-40f5-a1e9-e68a7d1b77bf" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_incy_InventoryNetCurrentAndNoncurrent_b53113d2-6478-4e7e-9e9b-a6f4af79e595" xlink:to="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_3354f626-4d4f-40f5-a1e9-e68a7d1b77bf" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.incyte.com/role/PropertyandEquipmentnetDetails" xlink:type="simple" xlink:href="incy-20240630.xsd#PropertyandEquipmentnetDetails"/>
  <link:calculationLink xlink:role="http://www.incyte.com/role/PropertyandEquipmentnetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_25072ba3-e53d-4c4f-902b-6aaa978801ea" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_96c43718-886c-44b0-bafd-31639a0f0946" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_25072ba3-e53d-4c4f-902b-6aaa978801ea" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_96c43718-886c-44b0-bafd-31639a0f0946" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_ab6653fb-d216-4bd4-b55c-0c911733a9cf" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_25072ba3-e53d-4c4f-902b-6aaa978801ea" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_ab6653fb-d216-4bd4-b55c-0c911733a9cf" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.incyte.com/role/AccruedandOtherCurrentLiabilitiesDetails" xlink:type="simple" xlink:href="incy-20240630.xsd#AccruedandOtherCurrentLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.incyte.com/role/AccruedandOtherCurrentLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_c688bea1-35f5-4651-bdce-01cb6ba2a711" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedRoyaltiesCurrent_75972e0d-cfd1-42b3-84d5-169d0d1f0f83" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccruedRoyaltiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_c688bea1-35f5-4651-bdce-01cb6ba2a711" xlink:to="loc_us-gaap_AccruedRoyaltiesCurrent_75972e0d-cfd1-42b3-84d5-169d0d1f0f83" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_incy_AccruedClinicalRelatedCostsCurrent_a14279da-8209-4185-8519-130ab50ac034" xlink:href="incy-20240630.xsd#incy_AccruedClinicalRelatedCostsCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_c688bea1-35f5-4651-bdce-01cb6ba2a711" xlink:to="loc_incy_AccruedClinicalRelatedCostsCurrent_a14279da-8209-4185-8519-130ab50ac034" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProvisionForLossOnContracts_a11c7803-9fe8-4653-9e21-c443d0ddc072" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProvisionForLossOnContracts"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_c688bea1-35f5-4651-bdce-01cb6ba2a711" xlink:to="loc_us-gaap_ProvisionForLossOnContracts_a11c7803-9fe8-4653-9e21-c443d0ddc072" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedMarketingCostsCurrent_44fb719a-0272-4545-86b1-3c594e9fd2da" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccruedMarketingCostsCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_c688bea1-35f5-4651-bdce-01cb6ba2a711" xlink:to="loc_us-gaap_AccruedMarketingCostsCurrent_44fb719a-0272-4545-86b1-3c594e9fd2da" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedIncomeTaxesCurrent_08a0b8e5-d5c1-46d6-8f0c-1f40d936024e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccruedIncomeTaxesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_c688bea1-35f5-4651-bdce-01cb6ba2a711" xlink:to="loc_us-gaap_AccruedIncomeTaxesCurrent_08a0b8e5-d5c1-46d6-8f0c-1f40d936024e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_085287df-3bfb-40d1-b35e-33d065244fa6" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_c688bea1-35f5-4651-bdce-01cb6ba2a711" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_085287df-3bfb-40d1-b35e-33d065244fa6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_fabbc8b0-790f-48a4-bdbf-1dc827296be6" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_c688bea1-35f5-4651-bdce-01cb6ba2a711" xlink:to="loc_us-gaap_OtherLiabilitiesCurrent_fabbc8b0-790f-48a4-bdbf-1dc827296be6" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.incyte.com/role/EmployeeBenefitplansScheduleofNetPeriodicBenefitCostDetails" xlink:type="simple" xlink:href="incy-20240630.xsd#EmployeeBenefitplansScheduleofNetPeriodicBenefitCostDetails"/>
  <link:calculationLink xlink:role="http://www.incyte.com/role/EmployeeBenefitplansScheduleofNetPeriodicBenefitCostDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_52818cba-9d10-49af-92aa-24dd64fee0ae" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanServiceCost_7ae807fa-1312-4412-93f5-ed5b14ece70b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanServiceCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_52818cba-9d10-49af-92aa-24dd64fee0ae" xlink:to="loc_us-gaap_DefinedBenefitPlanServiceCost_7ae807fa-1312-4412-93f5-ed5b14ece70b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanInterestCost_2066dc3c-636c-48c2-b02b-f3338c9dfd77" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanInterestCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_52818cba-9d10-49af-92aa-24dd64fee0ae" xlink:to="loc_us-gaap_DefinedBenefitPlanInterestCost_2066dc3c-636c-48c2-b02b-f3338c9dfd77" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_b41a421c-9318-4efd-8eb2-e025d50a5874" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_52818cba-9d10-49af-92aa-24dd64fee0ae" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_b41a421c-9318-4efd-8eb2-e025d50a5874" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanActuarialGainLoss_5f5141be-b0a9-4893-a5b4-d68b866bcf83" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanActuarialGainLoss"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_52818cba-9d10-49af-92aa-24dd64fee0ae" xlink:to="loc_us-gaap_DefinedBenefitPlanActuarialGainLoss_5f5141be-b0a9-4893-a5b4-d68b866bcf83" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit_bcf32a6d-8440-457e-8d70-0cc190050ec8" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_52818cba-9d10-49af-92aa-24dd64fee0ae" xlink:to="loc_us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit_bcf32a6d-8440-457e-8d70-0cc190050ec8" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
