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License Agreements - Novartis (Details) - USD ($) | 1 Months Ended | 3 Months Ended | 9 Months Ended | 179 Months Ended |
--- | --- | --- | --- | --- | ---
Nov. 30, 2009 | Sep. 30, 2024 | Sep. 30, 2023 | Sep. 30, 2024 | Sep. 30, 2023 | Sep. 30, 2024 | Dec. 31, 2023
License Agreements |  |  |  |  |  |  |
Total revenues |  | $ 1,137,871,000 | $ 919,025,000 | $ 3,062,519,000 | $ 2,682,308,000 |  |
JAKAFI |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |
Total revenues |  | 741,181,000 | 636,252,000 | 2,018,993,000 | 1,898,605,000 |  |
Novartis |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |
Total revenues |  | 0 | 5,000,000.0 | 0 | 5,000,000.0 |  |
Novartis | JAKAFI | UNITED STATES |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |
Total revenues |  | 36,300,000 | 31,100,000 | 93,900,000 | 88,000,000.0 |  |
Royalties payable |  | 469,500,000 |  | 469,500,000 |  | $ 469,500,000 | $ 375,600,000
Novartis | JAKAVI |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |
Total revenues |  | 115,700,000 | 96,600,000 | 304,700,000 | 263,700,000 |  |
Novartis | TABRECTA |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |
Total revenues |  | $ 5,900,000 | $ 4,100,000 | $ 16,500,000 | $ 13,100,000 |  |
Maximum | Novartis | JAKAVI |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  |  | 14.00% |  |  |
Minimum | Novartis | JAKAVI |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  |  | 12.00% |  |  |
Development Milestones | Novartis |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  | 157,000,000.0 |
Development Milestones | Maximum | Novartis |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement | $ 174,000,000.0 |  |  |  |  |  |
Regulatory Milestones | Novartis |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  | 345,000,000.0 |
Regulatory Milestones | Maximum | Novartis |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement | 495,000,000.0 |  |  |  |  |  |
Commercialization Milestones | Novartis |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  | $ 200,000,000.0 |
Commercialization Milestones | Maximum | Novartis |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement | 500,000,000.0 |  |  |  |  |  |
Development and Regulatory Milestones | Maximum | Novartis | GVHD |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement | $ 75,000,000.0 |  |  |  |  |  |

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