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License Agreements - Syndax (Details) - USD ($) $ in Thousands | 1 Months Ended | 3 Months Ended | 9 Months Ended | 37 Months Ended |
--- | --- | --- | --- | --- | ---
Aug. 31, 2024 | Sep. 30, 2021 | Sep. 30, 2024 | Sep. 30, 2023 | Sep. 30, 2024 | Sep. 30, 2023 | Sep. 30, 2024 | Dec. 31, 2023
License Agreements |  |  |  |  |  |  |  |  |
Long term equity investments |  |  | $ 27,566 |  | $ 27,566 |  | $ 27,566 | $ 187,716 | [1]
Research and development |  |  | $ 573,174 | $ 375,709 | $ 2,140,814 | $ 1,183,100 |  |  |
Investment in Syndax |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Common stock held from investment (in shares) |  |  | 1,400,000 |  | 1,400,000 |  | 1,400,000 |  |
Long term equity investments |  |  | $ 27,400 |  | $ 27,400 |  | $ 27,400 | 30,700 |
Unrealized gain (loss) on long term investments |  |  | (1,900) | (9,200) | (3,400) | (15,600) |  |  |
Syndax |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Upfront payment under license agreement |  |  |  |  |  |  | 129,500 |  |
Research and development |  |  | 5,800 | $ 5,100 | 17,600 | $ 16,900 |  |  |
Accrued and other liabilities |  |  | $ 1,800 |  | $ 1,800 |  | 1,800 | $ 1,800 |
Syndax | UNITED STATES | Syndax |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Funding of future development costs (as a percent) |  | 45.00% |  |  |  |  |  |  |
Syndax | Incyte |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Funding of future development costs (as a percent) |  |  | 55.00% | 55.00% | 55.00% | 55.00% |  |  |
Syndax | Incyte | UNITED STATES |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Funding of future development costs (as a percent) |  | 55.00% |  |  |  |  |  |  |
Syndax | Regulatory Milestone |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Milestone payment made under license agreement | $ 12,500 |  |  |  |  |  |  |  |
Milestone payment, estimated useful life (in years) | 10 years |  |  |  |  |  |  |  |
Syndax | Development and Regulatory Milestones | Maximum |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Additional milestone payments under the license agreement |  |  | $ 207,500 |  | $ 207,500 |  | 207,500 |  |
Syndax | Commercialization Milestones | Maximum |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Additional milestone payments under the license agreement |  |  | $ 230,000 |  | $ 230,000 |  | $ 230,000 |  |
[1] | The condensed consolidated balance sheet at December 31, 2023 has been derived from the audited consolidated financial statements at that date.

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