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Stockholders' Equity (Tables) | 12 Months Ended
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Dec. 31, 2024
Stockholders' Equity Note [Abstract] |
Schedule of Option Activity Under the 2010 Stock Plan | Option activity under the 2010 Stock Plan and 2024 Inducement Plan was as follows:
| Shares Subject to Outstanding Options
| Shares |  | Weighted Average Exercise Price
Balance at December 31, 2023 | 12,457,158 |  | $ | 85.40 |
Options granted | 1,336,397 |  | $ | 62.58 |
Options exercised | (430,563) |  | $ | 68.69 |
Options cancelled | (585,018) |  | $ | 88.22 |
Balance at December 31, 2024 | 12,777,974 |  | $ | 83.45 |
Schedule of Stock Options Outstanding and Exercisable by Exercise Price Range | The following table summarizes information about stock options outstanding as of December 31, 2024 under the 2010 Stock Plan and 2024 Inducement Plan:
|  | Options Outstanding |  | Options Exercisable
Range of Exercise Prices |  | Number Outstanding |  | Weighted Average Remaining Contractual Life (in years) |  | Weighted Average Exercise Price |  | Number Exercisable |  | Weighted Average Exercise Price
$52.94 - $61.76 |  | 1,443,974 |  | 8.50 |  | $ | 60.81 |  | 533,680 |  | $ | 61.16
$62.08 - $68.62 |  | 1,373,343 |  | 6.85 |  | 66.21 |  | 674,083 |  | 68.19
$68.70 - $74.78 |  | 1,971,358 |  | 5.41 |  | 73.13 |  | 1,791,120 |  | 73.10
$74.98 - $80.50 |  | 1,517,319 |  | 5.84 |  | 78.55 |  | 1,235,573 |  | 78.82
$80.56 - $83.58 |  | 1,449,127 |  | 6.69 |  | 83.26 |  | 1,163,248 |  | 83.27
$83.83 - $90.00 |  | 1,301,907 |  | 3.70 |  | 84.80 |  | 1,264,003 |  | 84.79
$90.56 - $95.34 |  | 1,354,618 |  | 4.55 |  | 92.79 |  | 1,353,093 |  | 92.79
$95.54 - $113.64 |  | 1,780,144 |  | 3.30 |  | 107.78 |  | 1,780,144 |  | 107.78
$115.19 - $134.38 |  | 568,742 |  | 2.39 |  | 128.65 |  | 568,742 |  | 128.65
$138.52 - $138.52 |  | 17,442 |  | 2.25 |  | 138.52 |  | 17,442 |  | 138.52
|  | 12,777,974 |  |  |  |  |  | 10,381,128 |  |
Schedule of Activity Summarized Under all Stock Plans other than Options | RSU and PSU award activity under the 2010 Stock Plan and 2024 Inducement Plan was as follows:
| Shares Subject to Outstanding Awards
| Shares |  | Grant Date Value
Balance at December 31, 2023 | 7,165,342 |  | $ | 72.17 |
RSUs granted | 3,481,911 |  | $ | 63.97 |
PSUs granted | 341,943 |  | $ | 65.40 |
RSUs released | (1,899,523) |  | $ | 75.55 |
PSUs released | (105,453) |  | $ | 83.58 |
RSUs cancelled | (317,347) |  | $ | 69.60 |
PSUs cancelled | (10,070) |  | $ | 76.59 |
Balance at December 31, 2024 | 8,656,803 |  | $ | 67.81 |
Schedule of Share Activity | The following table summarizes our shares available for grant under the 2010 Plan and 2024 Inducement Plan. E ach RSU and PSU grant reduces the available share pool by 2 shares.
| Shares Available for Grant
Balance at December 31, 2023 | 10,815,026
Additional authorization - 2024 Inducement Plan | 1,000,000
Options, RSUs and PSUs granted and issuance of shares for services rendered | (9,033,557)
Options, RSUs and PSUs cancelled | 1,232,142
Balance at December 31, 2024 | 4,013,611

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