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Revenues (Details) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022
Revenues |  |  |
Total revenues | $ 4,241,217 | $ 3,695,649 | $ 3,394,635
Product revenues, net |  |  |
Revenues |  |  |
Total revenues | 3,618,888 | 3,165,168 | 2,746,897
JAKAFI |  |  |
Revenues |  |  |
Total revenues | 2,792,107 | 2,593,732 | 2,409,225
OPZELURA |  |  |
Revenues |  |  |
Total revenues | 508,293 | 337,864 | 128,735
ICLUSIG |  |  |
Revenues |  |  |
Total revenues | 114,319 | 111,623 | 105,838
MINJUVI/MONJUVI |  |  |
Revenues |  |  |
Total revenues | 119,236 | 37,057 | 19,654
PEMAZYRE |  |  |
Revenues |  |  |
Total revenues | 81,748 | 83,642 | 83,445
ZYNYZ |  |  |
Revenues |  |  |
Total revenues | 3,185 | 1,250 | 0
Product royalty revenues |  |  |
Revenues |  |  |
Total revenues | 579,329 | 523,481 | 482,738
JAKAVI Royalty Revenues |  |  |
Revenues |  |  |
Total revenues | 418,840 | 367,583 | 331,575
OLUMIANT Royalty Revenues |  |  |
Revenues |  |  |
Total revenues | 135,572 | 136,138 | 134,547
TABRECTA Royalty Revenues |  |  |
Revenues |  |  |
Total revenues | 22,746 | 17,793 | 15,411
PEMAZYRE Royalty Revenues |  |  |
Revenues |  |  |
Total revenues | 2,171 | 1,967 | 1,205
Milestone and contract revenues |  |  |
Revenues |  |  |
Total revenues | $ 43,000 | $ 7,000 | $ 165,000

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