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License Agreements - Lily (Details) - USD ($) | 1 Months Ended | 12 Months Ended | 181 Months Ended
--- | --- | --- | ---
Dec. 31, 2009 | Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2024
License agreements |  |  |  |  |
Total revenues |  | $ 4,241,217,000 | $ 3,695,649,000 | $ 3,394,635,000 |
Eli Lilly |  |  |  |  |
License agreements |  |  |  |  |
Total revenues |  | 0 | 0 | 70,000,000.0 |
Eli Lilly | OLUMIANT |  |  |  |  |
License agreements |  |  |  |  |
Total revenues |  | $ 135,600,000 | $ 136,100,000 | $ 134,500,000 |
Development Milestones | Eli Lilly |  |  |  |  |
License agreements |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  | $ 149,000,000.0
Development Milestones | Maximum | Eli Lilly |  |  |  |  |
License agreements |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement | $ 150,000,000.0 |  |  |  |
Regulatory Milestones | Eli Lilly |  |  |  |  |
License agreements |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  | 335,000,000.0
Regulatory Milestones | Maximum | Eli Lilly |  |  |  |  |
License agreements |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement | 365,000,000.0 |  |  |  |
Commercialization Milestones | Eli Lilly |  |  |  |  |
License agreements |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  | $ 50,000,000.0
Commercialization Milestones | Maximum | Eli Lilly |  |  |  |  |
License agreements |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement | $ 150,000,000.0 |  |  |  |

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