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Stockholders' Equity - Narrative (Details) - USD ($) |  |  | 1 Months Ended | 12 Months Ended |  |  |  |  |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Jun. 26, 2024 | Jun. 13, 2024 | Jun. 30, 2024 | Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022 | May 14, 2024 | May 13, 2024 | May 12, 2024 | May 09, 2024 | Jan. 31, 2024 | Jun. 30, 2023 | May 31, 2023
Stock compensation |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred stock, shares authorized (in shares) |  |  |  | 5,000,000 | 5,000,000 |  |  |  |  |  |  |  |
Preferred stock, shares outstanding (in shares) |  |  |  | 0 | 0 |  |  |  |  |  |  |  |
Common stock, shares authorized (in shares) |  |  |  | 400,000,000 | 400,000,000 |  |  |  |  |  |  |  |
Stock repurchased (in shares) |  |  | 33,325,849 |  |  |  |  |  |  |  |  |  |
Shares acquired, average cost per share (in dollars per share) |  |  | $ 60.00 |  |  |  |  |  |  |  |  |  |
Repurchase of common stock |  |  | $ 2,000,000,000.0 | $ 2,023,975,000 |  |  |  |  |  |  |  |  |
Share repurchase, fees and expenses |  |  | 24,400,000 |  |  |  |  |  |  |  |  |  |
Share repurchase program, excise tax |  |  | $ 19,200,000 |  |  |  |  |  |  |  |  |  |
Shares reserved for future issuance related to stock plans (in shares) |  |  |  | 4,302,716 |  |  |  |  |  |  |  |  |
Options exercisable and vested (in shares) |  |  |  | 10,381,128 | 9,743,775 | 8,952,289 |  |  |  |  |  |  |
Intrinsic value of options exercised |  |  |  | $ 3,200,000 | $ 3,200,000 | $ 6,000,000.0 |  |  |  |  |  |  |
Intrinsic value of options outstanding |  |  |  | 15,900,000 |  |  |  |  |  |  |  |  |
Intrinsic value of vested options |  |  |  | 15,300,000 |  |  |  |  |  |  |  |  |
Stock compensation expense |  |  |  | $ 266,100,000 | $ 215,900,000 | $ 188,400,000 |  |  |  |  |  |  |
Issuance of shares of Common Stock under the ESPP (in shares) |  |  |  | 453,312 | 380,145 | 308,413 |  |  |  |  |  |  |
Remaining shares available (in shares) |  |  |  | 4,013,611 | 10,815,026 |  |  |  |  |  |  |  |
Employee Stock |  |  |  |  |  |  |  |  |  |  |  |  |
Stock compensation |  |  |  |  |  |  |  |  |  |  |  |  |
Shares reserved for future issuance related to stock plans (in shares) |  |  |  |  |  |  |  |  |  |  |  | 10,350,000 | 9,600,000
Stock compensation expense |  |  |  | $ 5,300,000 | $ 5,100,000 | $ 4,700,000 |  |  |  |  |  |  |
Employment period for eligibility to participate in the plan |  |  |  | 1 month |  |  |  |  |  |  |  |  |
Issuance of shares of Common Stock under the ESPP (in shares) |  |  |  | 453,312 | 380,145 | 308,413 |  |  |  |  |  |  |
Remaining shares available (in shares) |  |  |  | 289,105 |  |  |  |  |  |  |  |  |
Options |  |  |  |  |  |  |  |  |  |  |  |  |
Stock compensation |  |  |  |  |  |  |  |  |  |  |  |  |
Vesting period (in years) |  |  |  | 4 years |  |  |  |  |  |  |  |  |
Options | Share-based Payment Arrangement, Tranche One |  |  |  |  |  |  |  |  |  |  |  |  |
Stock compensation |  |  |  |  |  |  |  |  |  |  |  |  |
Vesting period (in years) |  |  |  | 1 year |  |  |  |  |  |  |  |  |
Percentage of units vesting at the end of each calendar year (as a percent) |  |  |  | 25.00% |  |  |  |  |  |  |  |  |
Options | Share-based Payment Arrangement, Tranche Two |  |  |  |  |  |  |  |  |  |  |  |  |
Stock compensation |  |  |  |  |  |  |  |  |  |  |  |  |
Vesting period (in years) |  |  |  | 36 months |  |  |  |  |  |  |  |  |
Restricted Stock Units (RSUs) |  |  |  |  |  |  |  |  |  |  |  |  |
Stock compensation |  |  |  |  |  |  |  |  |  |  |  |  |
Vesting period (in years) |  |  |  | 4 years |  |  |  |  |  |  |  |  |
Percentage of units vesting at the end of each calendar year (as a percent) |  |  |  | 25.00% |  |  |  |  |  |  |  |  |
Number of shares awarded for each RSU (in shares) |  |  |  | 1 |  |  |  |  |  |  |  |  |
Number of shares available for grant for each award granted (in shares) |  |  |  | 2 |  |  |  |  |  |  |  |  |
Performance Shares |  |  |  |  |  |  |  |  |  |  |  |  |
Stock compensation |  |  |  |  |  |  |  |  |  |  |  |  |
Vesting period (in years) |  |  |  | 4 years |  |  |  |  |  |  |  |  |
Stock compensation expense |  |  |  | $ 30,100,000 | $ 17,200,000 | $ 7,800,000 |  |  |  |  |  |  |
Number of shares available for grant for each award granted (in shares) |  |  |  | 2 |  |  |  |  |  |  |  |  |
Non-employee Director | Options |  |  |  |  |  |  |  |  |  |  |  |  |
Stock compensation |  |  |  |  |  |  |  |  |  |  |  |  |
Expiration period (in years) |  |  |  | 10 years |  |  |  |  |  |  |  |  |
Stock Incentive Plan 2010 |  |  |  |  |  |  |  |  |  |  |  |  |
Stock compensation |  |  |  |  |  |  |  |  |  |  |  |  |
Shares reserved for future issuance related to stock plans (in shares) |  |  | 66,453,475 |  |  |  |  |  |  |  |  |  | 53,953,475
2024 Inducement Plan |  |  |  |  |  |  |  |  |  |  |  |  |
Stock compensation |  |  |  |  |  |  |  |  |  |  |  |  |
Shares reserved for future issuance related to stock plans (in shares) |  |  |  |  |  |  |  |  |  |  | 1,000,000 |  |
Incyte | Baker Entities |  |  |  |  |  |  |  |  |  |  |  |  |
Stock compensation |  |  |  |  |  |  |  |  |  |  |  |  |
Subsidiary, ownership percentage, noncontrolling owner (as percent) |  |  |  |  |  |  |  |  |  | 16.40% |  |  |
Maximum | Performance Shares |  |  |  |  |  |  |  |  |  |  |  |  |
Stock compensation |  |  |  |  |  |  |  |  |  |  |  |  |
Vesting period (in years) |  |  |  | 4 years |  |  |  |  |  |  |  |  |
Minimum | Employee Stock |  |  |  |  |  |  |  |  |  |  |  |  |
Stock compensation |  |  |  |  |  |  |  |  |  |  |  |  |
Number of employee working hours per week for eligibility to participate in the plan |  |  |  | 20 hours |  |  |  |  |  |  |  |  |
Minimum | Performance Shares |  |  |  |  |  |  |  |  |  |  |  |  |
Stock compensation |  |  |  |  |  |  |  |  |  |  |  |  |
Vesting period (in years) |  |  |  | 3 years |  |  |  |  |  |  |  |  |
Board of Directors Approved Share Repurchase Program |  |  |  |  |  |  |  |  |  |  |  |  |
Stock compensation |  |  |  |  |  |  |  |  |  |  |  |  |
Share repurchase program, authorized, amount |  |  |  |  |  |  |  | $ 2,000,000,000.0 |  |  |  |  |
Dutch Auction Tender Offer |  |  |  |  |  |  |  |  |  |  |  |  |
Stock compensation |  |  |  |  |  |  |  |  |  |  |  |  |
Share repurchase program, authorized, amount |  |  |  |  |  |  | $ 1,672,000,000 |  |  |  |  |  |
Stock repurchased (in shares) |  | 27,866,666 |  |  |  |  |  |  |  |  |  |  |
Shares acquired, average cost per share (in dollars per share) |  | $ 60.00 |  |  |  |  |  |  |  |  |  |  |
Repurchase of common stock |  | $ 1,672,000,000 |  |  |  |  |  |  |  |  |  |  |
Dutch Auction Tender Offer | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |
Stock compensation |  |  |  |  |  |  |  |  |  |  |  |  |
Share repurchase program, tender offer (in dollars per share) |  |  |  |  |  |  |  | $ 60.00 |  |  |  |  |
Dutch Auction Tender Offer | Minimum |  |  |  |  |  |  |  |  |  |  |  |  |
Stock compensation |  |  |  |  |  |  |  |  |  |  |  |  |
Share repurchase program, tender offer (in dollars per share) |  |  |  |  |  |  |  | $ 52.00 |  |  |  |  |
Baker Entities Share Repurchase Program |  |  |  |  |  |  |  |  |  |  |  |  |
Stock compensation |  |  |  |  |  |  |  |  |  |  |  |  |
Share repurchase program, authorized, amount |  |  |  |  |  |  |  |  | $ 328,000,000 |  |  |  |
Stock repurchased (in shares) | 5,459,183 |  |  |  |  |  |  |  |  |  |  |  |
Shares acquired, average cost per share (in dollars per share) | $ 60.00 |  |  |  |  |  |  |  |  |  |  |  |
Repurchase of common stock | $ 328,000,000 |  |  |  |  |  |  |  |  |  |  |  |

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