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License Agreements - MacroGenics (Details) - USD ($) $ in Thousands | 12 Months Ended | 87 Months Ended |
--- | --- | --- | ---
Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2024 | Jul. 31, 2024
License agreements |  |  |  |  |
Research and development | $ 2,606,848 | $ 1,627,594 | $ 1,585,936 |  |
MacroGenics |  |  |  |  |
License agreements |  |  |  |  |
License agreement, amount payable for waiver of certain future milestones payment |  |  |  |  | $ 100,000
Milestone payment made under license agreement | 100,000 |  |  |  |
Research and development | 45,700 | 51,500 | $ 89,200 |  |
MacroGenics | Accrued Liabilities |  |  |  |  |
License agreements |  |  |  |  |
Accrued and other liabilities | $ 500 | $ 300 |  | $ 500 |
MacroGenics | Minimum |  |  |  |  |
License agreements |  |  |  |  |
Royalty payments on future global net sales (as percent) | 15.00% |  |  |  |
MacroGenics | Maximum |  |  |  |  |
License agreements |  |  |  |  |
Royalty payments on future global net sales (as percent) | 24.00% |  |  |  |
MacroGenics | Development Milestones |  |  |  |  |
License agreements |  |  |  |  |
Milestone payment made under license agreement |  |  |  | 215,000 |
MacroGenics | Development and Regulatory Milestones | Maximum |  |  |  |  |
License agreements |  |  |  |  |
Additional milestone payments under the license agreement | $ 210,000 |  |  | 210,000 |
MacroGenics | Commercialization Milestones | Maximum |  |  |  |  |
License agreements |  |  |  |  |
Additional milestone payments under the license agreement | $ 330,000 |  |  | $ 330,000 |

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