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Income Taxes - Schedule of Reconciliation of Income Taxes (Details) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022
Reconciliation of income taxes at the U.S. federal statutory rate to the provision for income taxes |  |  |
Provision at U.S. federal statutory rate | $ 66,492 | $ 175,185 | $ 111,114
State and local income taxes | 51,753 | 21,145 | 26,767
Foreign tax rate differential | 61,026 | (96,434) | 13,670
Income tax credits | (70,989) | (1,433,507) | (30,505)
Change in valuation allowance | 21,425 | 1,572,951 | 67,056
Change in uncertain tax positions | 6,418 | 5,943 | 3,262
Foreign-derived intangible income | (31,786) | (32,891) | (36,748)
Stock based compensation | 25,647 | 20,971 | 19,704
Acquisitions accounted for as research and development expenses | 149,287 | 4,200 | 14,700
Other | 4,742 | (947) | (564)
Total provision for income taxes | 284,015 | 236,616 | $ 188,456
Deferred tax assets: |  |  |
Net operating loss carry forwards | 315,969 | 326,446 |
Income tax credits | 1,398,495 | 1,441,981 |
Capitalized research and development | 648,989 | 457,603 |
Deferred revenue and accruals | 190,446 | 130,291 |
Non-cash compensation | 100,788 | 96,469 |
Acquisition-related contingent consideration | 27,796 | 30,298 |
Intangibles, net | 229,741 | 233,311 |
Long term investments | 6,697 | 42,975 |
Other | 20,814 | 9,044 |
Total gross deferred tax assets | 2,939,735 | 2,768,418 |
Less valuation allowance for deferred tax assets | (2,139,673) | (2,096,318) |
Net deferred tax assets | 800,062 | 672,100 |
Deferred tax liabilities: |  |  |
Property and equipment | (30,676) | (34,757) |
Other | (7,315) | (5,457) |
Total gross deferred tax liabilities | (37,991) | (40,214) |
Net deferred tax assets | $ 762,071 | $ 631,886 |

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- Definition Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to research tax credit. + References Reference 1: http://www.xbrl.org/2003/role/exampleRef -Topic 740 -SubTopic 10 -Name Accounting Standards Codification -Section 55 -Paragraph 231 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482663/740-10-55-231 Reference 2: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 740 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 12A -Subparagraph (b)(1) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482685/740-10-50-12A Reference 3: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 740 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 12 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482685/740-10-50-12 + Details
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