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Stockholders' Equity - Narrative (Details) - USD ($)
 1 Months Ended 12 Months Ended
Jun. 26, 2024
Jun. 13, 2024
Jun. 30, 2024
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
May 14, 2024
May 13, 2024
May 12, 2024
May 09, 2024
Jan. 31, 2024
Jun. 30, 2023
May 31, 2023
Stock compensation                          
Preferred stock, shares authorized (in shares)       5,000,000 5,000,000                
Preferred stock, shares outstanding (in shares)       0 0                
Common stock, shares authorized (in shares)       400,000,000 400,000,000                
Stock repurchased (in shares)     33,325,849                    
Shares acquired, average cost per share (in dollars per share)     $ 60.00                    
Repurchase of common stock     $ 2,000,000,000.0 $ 2,023,975,000                  
Share repurchase, fees and expenses     24,400,000                    
Share repurchase program, excise tax     $ 19,200,000                    
Shares reserved for future issuance related to stock plans (in shares)       4,302,716                  
Options exercisable and vested (in shares)       10,381,128 9,743,775 8,952,289              
Intrinsic value of options exercised       $ 3,200,000 $ 3,200,000 $ 6,000,000.0              
Intrinsic value of options outstanding       15,900,000                  
Intrinsic value of vested options       15,300,000                  
Stock compensation expense       $ 266,100,000 $ 215,900,000 $ 188,400,000              
Issuance of shares of Common Stock under the ESPP (in shares)       453,312 380,145 308,413              
Remaining shares available (in shares)       4,013,611 10,815,026                
Employee Stock                          
Stock compensation                          
Shares reserved for future issuance related to stock plans (in shares)                       10,350,000 9,600,000
Stock compensation expense       $ 5,300,000 $ 5,100,000 $ 4,700,000              
Employment period for eligibility to participate in the plan       1 month                  
Issuance of shares of Common Stock under the ESPP (in shares)       453,312 380,145 308,413              
Remaining shares available (in shares)       289,105                  
Options                          
Stock compensation                          
Vesting period (in years)       4 years                  
Options | Share-based Payment Arrangement, Tranche One                          
Stock compensation                          
Vesting period (in years)       1 year                  
Percentage of units vesting at the end of each calendar year (as a percent)       25.00%                  
Options | Share-based Payment Arrangement, Tranche Two                          
Stock compensation                          
Vesting period (in years)       36 months                  
Restricted Stock Units (RSUs)                          
Stock compensation                          
Vesting period (in years)       4 years                  
Percentage of units vesting at the end of each calendar year (as a percent)       25.00%                  
Number of shares awarded for each RSU (in shares)       1                  
Number of shares available for grant for each award granted (in shares)       2                  
Performance Shares                          
Stock compensation                          
Vesting period (in years)       4 years                  
Stock compensation expense       $ 30,100,000 $ 17,200,000 $ 7,800,000              
Number of shares available for grant for each award granted (in shares)       2                  
Non-employee Director | Options                          
Stock compensation                          
Expiration period (in years)       10 years                  
Stock Incentive Plan 2010                          
Stock compensation                          
Shares reserved for future issuance related to stock plans (in shares)     66,453,475                   53,953,475
2024 Inducement Plan                          
Stock compensation                          
Shares reserved for future issuance related to stock plans (in shares)                     1,000,000    
Incyte | Baker Entities                          
Stock compensation                          
Subsidiary, ownership percentage, noncontrolling owner (as percent)                   16.40%      
Maximum | Performance Shares                          
Stock compensation                          
Vesting period (in years)       4 years                  
Minimum | Employee Stock                          
Stock compensation                          
Number of employee working hours per week for eligibility to participate in the plan       20 hours                  
Minimum | Performance Shares                          
Stock compensation                          
Vesting period (in years)       3 years                  
Board of Directors Approved Share Repurchase Program                          
Stock compensation                          
Share repurchase program, authorized, amount               $ 2,000,000,000.0          
Dutch Auction Tender Offer                          
Stock compensation                          
Share repurchase program, authorized, amount             $ 1,672,000,000            
Stock repurchased (in shares)   27,866,666                      
Shares acquired, average cost per share (in dollars per share)   $ 60.00                      
Repurchase of common stock   $ 1,672,000,000                      
Dutch Auction Tender Offer | Maximum                          
Stock compensation                          
Share repurchase program, tender offer (in dollars per share)               $ 60.00          
Dutch Auction Tender Offer | Minimum                          
Stock compensation                          
Share repurchase program, tender offer (in dollars per share)               $ 52.00          
Baker Entities Share Repurchase Program                          
Stock compensation                          
Share repurchase program, authorized, amount                 $ 328,000,000        
Stock repurchased (in shares) 5,459,183                        
Shares acquired, average cost per share (in dollars per share) $ 60.00                        
Repurchase of common stock $ 328,000,000