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License Agreements - Syndax (Details) - USD ($) $ in Thousands | 1 Months Ended | 3 Months Ended | 43 Months Ended |
--- | --- | --- | --- | ---
Aug. 31, 2024 | Sep. 30, 2021 | Mar. 31, 2025 | Mar. 31, 2024 | Mar. 31, 2025 | Dec. 31, 2024
License Agreements |  |  |  |  |  |  |
Long term equity investments |  |  | $ 17,463 |  | $ 17,463 | $ 18,814 | [1]
Research and development |  |  | $ 437,279 | $ 429,260 |  |  |
Investment in Syndax |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |
Common stock held from investment (in shares) |  |  | 1,400,000 |  | 1,400,000 |  |
Long term equity investments |  |  | $ 17,500 |  | $ 17,500 | 18,800 |
Unrealized gain (loss) on long term investments |  |  | (1,300) | 3,100 |  |  |
Syndax |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |
Upfront payment under license agreement |  |  |  |  | 129,500 |  |
Research and development |  |  | 4,700 | $ 7,100 |  |  |
Accrued and other liabilities |  |  | $ 2,100 |  | 2,100 | $ 2,200 |
Syndax | UNITED STATES | Syndax |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |
Funding of future development costs (as a percent) |  | 45.00% |  |  |  |  |
Syndax | Incyte |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |
Funding of future development costs (as a percent) |  |  | 55.00% | 55.00% |  |  |
Syndax | Incyte | UNITED STATES |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |
Funding of future development costs (as a percent) |  | 55.00% |  |  |  |  |
Syndax | Regulatory Milestone |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |
Milestone payment made under license agreement | $ 12,500 |  |  |  |  |  |
Milestone payment, estimated useful life (in years) | 10 years |  |  |  |  |  |
Syndax | Development and Regulatory Milestones | Maximum |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |
Additional milestone payments under the license agreement |  |  | $ 207,500 |  | 207,500 |  |
Syndax | Commercialization Milestones | Maximum |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |
Additional milestone payments under the license agreement |  |  | $ 230,000 |  | $ 230,000 |  |
[1] | The condensed consolidated balance sheet at December 31, 2024 has been derived from the audited consolidated financial statements at that date.

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