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CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended
Mar. 31, 2025
Mar. 31, 2024
Revenues:    
Total revenues $ 1,052,898 $ 880,889
Costs, expenses and other:    
Cost of product revenues (including definite-lived intangible amortization) 73,188 60,956
Research and development 437,279 429,260
Selling, general and administrative 325,691 300,256
Loss (gain) on change in fair value of acquisition-related contingent consideration 11,572 (456)
(Profit) and loss sharing under collaboration agreements 0 (1,025)
Total costs, expenses and other 847,730 788,991
Income from operations 205,168 91,898
Interest income 22,929 46,770
Interest expense (660) (430)
(Loss) gain on equity investments (1,343) 99,947
Other, net 8,096 (2,026)
Income before provision for income taxes 234,190 236,159
Provision for income taxes 75,987 66,611
Net income $ 158,203 $ 169,548
Net income per share:    
Basic (in USD per share) $ 0.82 $ 0.76
Diluted (in USD per share) $ 0.80 $ 0.75
Shares used in computing net income per share:    
Basic (in shares) 193,712 224,484
Diluted (in shares) 198,197 227,219
Product revenues, net    
Revenues:    
Total revenues $ 922,274 $ 729,923
Product royalty revenues    
Revenues:    
Total revenues 130,624 125,966
Milestone and contract revenues    
Revenues:    
Total revenues $ 0 $ 25,000