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License Agreements - Syndax (Details) - USD ($) $ in Thousands	1 Months Ended		3 Months Ended		43 Months Ended
	Aug. 31, 2024	Sep. 30, 2021	Mar. 31, 2025	Mar. 31, 2024	Mar. 31, 2025	Dec. 31, 2024
License Agreements
Long term equity investments			$ 17,463		$ 17,463	$ 18,814	[1]
Research and development			$ 437,279	$ 429,260
Investment in Syndax
License Agreements
Common stock held from investment (in shares)			1,400,000		1,400,000
Long term equity investments			$ 17,500		$ 17,500	18,800
Unrealized gain (loss) on long term investments			(1,300)	3,100
Syndax
License Agreements
Upfront payment under license agreement					129,500
Research and development			4,700	$ 7,100
Accrued and other liabilities			$ 2,100		2,100	$ 2,200
Syndax | UNITED STATES | Syndax
License Agreements
Funding of future development costs (as a percent)		45.00%
Syndax | Incyte
License Agreements
Funding of future development costs (as a percent)			55.00%	55.00%
Syndax | Incyte | UNITED STATES
License Agreements
Funding of future development costs (as a percent)		55.00%
Syndax | Regulatory Milestone
License Agreements
Milestone payment made under license agreement	$ 12,500
Milestone payment, estimated useful life (in years)	10 years
Syndax | Development and Regulatory Milestones | Maximum
License Agreements
Additional milestone payments under the license agreement			$ 207,500		207,500
Syndax | Commercialization Milestones | Maximum
License Agreements
Additional milestone payments under the license agreement			$ 230,000		$ 230,000
[1] The condensed consolidated balance sheet at December 31, 2024 has been derived from the audited consolidated financial statements at that date.

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