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License Agreements - Lilly (Details) - USD ($) $ in Thousands | 1 Months Ended | 3 Months Ended | 6 Months Ended | 187 Months Ended
--- | --- | --- | --- | ---
Dec. 31, 2009 | Jun. 30, 2025 | Jun. 30, 2024 | Jun. 30, 2025 | Jun. 30, 2024 | Jun. 30, 2025
License Agreements |  |  |  |  |  |
Total revenues |  | $ 1,215,529 | $ 1,043,759 | $ 2,268,427 | $ 1,924,648 |
Eli Lilly | OLUMIANT |  |  |  |  |  |
License Agreements |  |  |  |  |  |
Total revenues |  | $ 33,500 | $ 31,700 | $ 64,300 | $ 62,300 |
Development Milestones | Eli Lilly |  |  |  |  |  |
License Agreements |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  | $ 149,000
Development Milestones | Maximum | Eli Lilly |  |  |  |  |  |
License Agreements |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement | $ 150,000 |  |  |  |  |
Regulatory Milestones | Eli Lilly |  |  |  |  |  |
License Agreements |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  | 335,000
Regulatory Milestones | Maximum | Eli Lilly |  |  |  |  |  |
License Agreements |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement | 365,000 |  |  |  |  |
Commercialization Milestones | Eli Lilly |  |  |  |  |  |
License Agreements |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  | $ 50,000
Commercialization Milestones | Maximum | Eli Lilly |  |  |  |  |  |
License Agreements |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement | $ 150,000 |  |  |  |  |

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