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Segment Reporting (Tables)

6 Months Ended

Jun. 30, 2025

Segment Reporting [Abstract]

Schedule of Segment Reporting Information, by Segment

Net income for our segment was as follows (in thousands):

			Three Months Ended June 30,												Six Months Ended June 30,
			2025						2024						2025						2024
Product revenues, net			$	1,059,414					$	906,566					$	1,981,688					$	1,636,489
Product royalty revenues			151,115						137,193						281,739						263,159
Milestone and contract revenues			5,000						—						5,000						25,000
Total revenues			1,215,529						1,043,759						2,268,427						1,924,648
Costs, expenses and other:
Cost of product revenues (including definite-lived intangible amortization)			78,766						76,634						151,954						137,590
Contract dispute settlement			(242,251)						—						(242,251)						—
Research and development - internal1			236,686						234,635						465,031						456,731
Research and development - external2			245,681						223,944						439,115						430,108
Other research and development3			12,550						679,801						28,050						680,801
Sales and marketing			256,311						229,202						513,963						446,015
General and administrative			74,711						76,780						142,750						160,223
Loss on change in fair value of acquisition-related contingent consideration			22,761						893						34,333						437
(Profit) and loss sharing under collaboration agreements			—						—						—						(1,025)
Other segment items4			125,315						(33,529)						172,280						(111,179)
Net income (loss)			$	404,999					$	(444,601)					$	563,202					$	(275,053)

1.Research and development - internal is comprised of internally generated costs such as salaries, travel, regulatory costs, lab costs, contracting, etc.

2.Research and development - external is comprised of specific program spend with external vendors (i.e. contract manufacturing organization, contract research organization and lab vendors for clinical, technical operations and toxicology services).

3.Other research and development is comprised of all other costs including certain one-time costs resulting from the acquisition of IPR&D assets and one-time development milestone expenses.

4.Other segment items is comprised of interest income, interest expense, realized and unrealized (gain) loss on equity investments, other, net, and provision for income taxes

Schedule of Revenue from External Customers by Geographic Areas

Total revenues by geographic region consisted of the following (in thousands):

			Three Months Ended June 30,												Six Months Ended June 30,
			2025						2024						2025						2024
United States			$	1,132,353					$	989,029					$	2,113,910					$	1,817,193
Europe			78,826						53,586						147,438						105,117
Other countries			4,350						1,144						7,079						2,338
Total revenues			$	1,215,529					$	1,043,759					$	2,268,427					$	1,924,648

Schedule of Long-Lived Assets by Geographic Areas

Property and equipment, net by geographic location was as follows (in thousands):

			June 30, 2025						December 31, 2024
United States			$	474,384					$	474,095
Switzerland			310,206						277,623
Other countries			13,953						11,693
Total property and equipment, net			$	798,543					$	763,411

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- Definition

Tabular disclosure of long-lived assets, excluding financial instruments, long-term customer relationships of a financial institution, mortgage rights, deferred policy acquisition costs, and deferred tax assets, by geographic areas located in the entity's country of domicile and foreign countries in which the entity holds assets.

+ References

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-Topic 280
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-Name Accounting Standards Codification
-Section 50
-Paragraph 41
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Tabular disclosure of the profit or loss and total assets for each reportable segment. An entity discloses certain information on each reportable segment if the amounts (a) are included in the measure of segment profit or loss reviewed by the chief operating decision maker or (b) are otherwise regularly provided to the chief operating decision maker, even if not included in that measure of segment profit or loss.

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