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License Agreements - Novartis (Details) - USD ($) $ in Thousands		1 Months Ended	3 Months Ended			6 Months Ended		188 Months Ended
	May 11, 2025	Nov. 30, 2009	Jun. 30, 2025	Mar. 31, 2025	Jun. 30, 2024	Jun. 30, 2025	Jun. 30, 2024	Jun. 30, 2025	Dec. 31, 2024
License Agreements
Contract dispute settlement			$ 242,251		$ 0	$ 242,251	$ 0
Total revenues			1,215,529		1,043,759	2,268,427	1,924,648
United States
License Agreements
Total revenues			1,132,353		989,029	2,113,910	1,817,193
JAKAFI
License Agreements
Total revenues			763,788		705,973	1,473,200	1,277,812
Novartis | JAKAFI
License Agreements
Royalties payable				$ 537,100
Litigation settlement, amount awarded to other party	$ 280,000
Royalty rate payable, percent reduction (as a percent)	50.00%
Decrease in royalties payable				$ 14,900
Contract dispute settlement			242,200			242,200
Novartis | JAKAFI | United States
License Agreements
Royalties payable			18,700			18,700		$ 18,700	$ 507,400
Total revenues			18,700		34,600	48,500	57,600
Novartis | JAKAVI
License Agreements
Total revenues			109,700		99,300	201,900	188,900
Novartis | TABRECTA
License Agreements
Total revenues			$ 6,600		$ 5,300	$ 13,000	$ 10,500
Maximum | Novartis | JAKAVI
License Agreements
Royalty payments on future global net sales (as a percent)						14.00%
Minimum | Novartis | JAKAVI
License Agreements
Royalty payments on future global net sales (as a percent)						12.00%
Development Milestones | Novartis
License Agreements
Amount recognized and received for the achievement of a predefined milestone								157,000
Development Milestones | Maximum | Novartis
License Agreements
Upfront and immediate milestone payment to be received under license agreement		$ 174,000
Regulatory Milestones | Novartis
License Agreements
Amount recognized and received for the achievement of a predefined milestone								345,000
Regulatory Milestones | Maximum | Novartis
License Agreements
Upfront and immediate milestone payment to be received under license agreement		495,000
Commercialization Milestones | Novartis
License Agreements
Amount recognized and received for the achievement of a predefined milestone								$ 200,000
Commercialization Milestones | Maximum | Novartis
License Agreements
Upfront and immediate milestone payment to be received under license agreement		500,000
Development and Regulatory Milestones | Maximum | Novartis | GVHD
License Agreements
Upfront and immediate milestone payment to be received under license agreement		$ 75,000

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