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Segment Reporting - Schedule of Consolidated Net Income (Details) - USD ($)
$ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2025
Mar. 31, 2025
Jun. 30, 2024
Mar. 31, 2024
Jun. 30, 2025
Jun. 30, 2024
Revenues from External Customers and Long-Lived Assets [Line Items]            
Total revenues $ 1,215,529   $ 1,043,759   $ 2,268,427 $ 1,924,648
Costs, expenses and other:            
Cost of product revenues (including definite-lived intangible amortization) 78,766   76,634   151,954 137,590
Contract dispute settlement (242,251)   0   (242,251) 0
Loss on change in fair value of acquisition-related contingent consideration 22,761   893   34,333 437
(Profit) and loss sharing under collaboration agreements 0   0   0 (1,025)
Net income (loss) 404,999 $ 158,203 (444,601) $ 169,548 563,202 (275,053)
Reportable Segment            
Revenues from External Customers and Long-Lived Assets [Line Items]            
Total revenues 1,215,529   1,043,759   2,268,427 1,924,648
Costs, expenses and other:            
Cost of product revenues (including definite-lived intangible amortization) 78,766   76,634   151,954 137,590
Contract dispute settlement (242,251)   0   (242,251) 0
Research and development - internal 236,686   234,635   465,031 456,731
Research and development - external 245,681   223,944   439,115 430,108
Other research and development 12,550   679,801   28,050 680,801
Sales and marketing 256,311   229,202   513,963 446,015
General and administrative 74,711   76,780   142,750 160,223
Loss on change in fair value of acquisition-related contingent consideration 22,761   893   34,333 437
(Profit) and loss sharing under collaboration agreements 0   0   0 (1,025)
Other segment items 125,315   (33,529)   172,280 (111,179)
Net income (loss) 404,999   (444,601)   563,202 (275,053)
Product revenues, net            
Revenues from External Customers and Long-Lived Assets [Line Items]            
Total revenues 1,059,414   906,566   1,981,688 1,636,489
Product revenues, net | Reportable Segment            
Revenues from External Customers and Long-Lived Assets [Line Items]            
Total revenues 1,059,414   906,566   1,981,688 1,636,489
Product royalty revenues            
Revenues from External Customers and Long-Lived Assets [Line Items]            
Total revenues 151,115   137,193   281,739 263,159
Product royalty revenues | Reportable Segment            
Revenues from External Customers and Long-Lived Assets [Line Items]            
Total revenues 151,115   137,193   281,739 263,159
Milestone and contract revenues            
Revenues from External Customers and Long-Lived Assets [Line Items]            
Total revenues 5,000   0   5,000 25,000
Milestone and contract revenues | Reportable Segment            
Revenues from External Customers and Long-Lived Assets [Line Items]            
Total revenues $ 5,000   $ 0   $ 5,000 $ 25,000