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License Agreements - Novartis (Details) - USD ($) $ in Thousands |  | 1 Months Ended | 3 Months Ended | 9 Months Ended | 191 Months Ended |
--- | --- | --- | --- | --- | --- | ---
May 11, 2025 | Nov. 30, 2009 | Sep. 30, 2025 | Mar. 31, 2025 | Sep. 30, 2024 | Sep. 30, 2025 | Sep. 30, 2024 | Sep. 30, 2025 | Dec. 31, 2024
License Agreements |  |  |  |  |  |  |  |  |
Contract dispute settlement |  |  | $ 0 |  | $ 0 | $ 242,251 | $ 0 |  |
Total revenues |  |  | 1,365,980 |  | 1,137,871 | 3,634,407 | 3,062,519 |  |
United States |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Total revenues |  |  | 1,261,261 |  | 1,070,040 | 3,375,171 | 2,887,233 |  |
JAKAFI |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Total revenues |  |  | 791,071 |  | 741,181 | 2,264,271 | 2,018,993 |  |
Novartis | JAKAFI |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Royalties payable |  |  |  | $ 537,100 |  |  |  |  |
Litigation settlement, amount awarded to other party | $ 280,000 |  |  |  |  |  |  |  |
Royalty rate payable, percent reduction (as a percent) | 50.00% |  |  |  |  |  |  |  |
Decrease in royalties payable |  |  |  | $ 14,900 |  |  |  |  |
Contract dispute settlement |  |  |  |  |  | 242,200 |  |  |
Novartis | JAKAFI | United States |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Royalties payable |  |  | 19,400 |  |  | 19,400 |  | $ 19,400 | $ 507,400
Total revenues |  |  | 19,300 |  | 36,300 | 67,800 | 93,900 |  |
Novartis | JAKAVI |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Total revenues |  |  | 125,600 |  | 115,700 | 327,500 | 304,700 |  |
Novartis | TABRECTA |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Total revenues |  |  | $ 6,500 |  | $ 5,900 | $ 19,600 | $ 16,500 |  |
Maximum | Novartis | JAKAVI |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  |  |  |  | 14.00% |  |  |
Minimum | Novartis | JAKAVI |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  |  |  |  | 12.00% |  |  |
Development Milestones | Novartis |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  | 157,000 |
Development Milestones | Maximum | Novartis |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  | $ 174,000 |  |  |  |  |  |  |
Regulatory Milestones | Novartis |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  | 345,000 |
Regulatory Milestones | Maximum | Novartis |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  | 495,000 |  |  |  |  |  |  |
Commercialization Milestones | Novartis |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  | $ 200,000 |
Commercialization Milestones | Maximum | Novartis |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  | 500,000 |  |  |  |  |  |  |
Development and Regulatory Milestones | Maximum | Novartis | GVHD |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  | $ 75,000 |  |  |  |  |  |  |

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