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CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2025
Sep. 30, 2024
Sep. 30, 2025
Sep. 30, 2024
Revenues:        
Total revenues $ 1,365,980 $ 1,137,871 $ 3,634,407 $ 3,062,519
Costs, expenses and other:        
Cost of product revenues (including definite-lived intangible amortization) 99,001 85,993 250,955 223,583
Contract dispute settlement 0 0 (242,251) 0
Research and development 506,584 573,174 1,438,780 2,140,814
Selling, general and administrative 329,081 309,209 985,794 915,447
(Gain) loss on change in fair value of acquisition-related contingent consideration (12,204) 23,410 22,129 23,847
(Profit) and loss sharing under collaboration agreements 0 0 0 (1,025)
Total costs, expenses and other 922,462 991,786 2,455,407 3,302,666
Income (loss) from operations 443,518 146,085 1,179,000 (240,147)
Interest income 26,781 19,266 74,846 107,512
Interest expense (592) (774) (1,846) (1,861)
Gain (loss) on equity investments 8,558 (12,982) 3,064 126,206
Other, net 4,043 4,929 19,446 11,196
Income before provision for income taxes 482,308 156,524 1,274,510 2,906
Provision for income taxes 58,139 50,068 287,139 171,503
Net income (loss) $ 424,169 $ 106,456 $ 987,371 $ (168,597)
Net income (loss) per share:        
Basic (in USD per share) $ 2.17 $ 0.55 $ 5.08 $ (0.80)
Diluted (in USD per share) $ 2.11 $ 0.54 $ 4.95 $ (0.80)
Shares used in computing net income (loss) per share:        
Basic (in shares) 195,670 192,629 194,459 211,763
Diluted (in shares) 201,429 195,838 199,405 211,763
Product revenues, net        
Revenues:        
Total revenues $ 1,149,856 $ 962,992 $ 3,131,544 $ 2,599,481
Product royalty revenues        
Revenues:        
Total revenues 171,124 156,879 452,863 420,038
Milestone and contract revenues        
Revenues:        
Total revenues $ 45,000 $ 18,000 $ 50,000 $ 43,000