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Segment Reporting (Tables)

9 Months Ended

Sep. 30, 2025

Segment Reporting [Abstract]

Schedule of Segment Reporting Information, by Segment

Net income for our segment was as follows (in thousands):

			Three Months Ended September 30,												Nine Months Ended September 30,
			2025						2024						2025						2024
Product revenues, net			$	1,149,856					$	962,992					$	3,131,544					$	2,599,481
Product royalty revenues			171,124						156,879						452,863						420,038
Milestone and contract revenues			45,000						18,000						50,000						43,000
Total revenues			1,365,980						1,137,871						3,634,407						3,062,519
Costs, expenses and other:
Cost of product revenues (including definite-lived intangible amortization)			99,001						85,993						250,955						223,583
Contract dispute settlement			—						—						(242,251)						—
Research and development - internal1			250,140						250,477						715,171						707,208
Research and development - external2			256,344						222,697						695,459						652,805
Other research and development3			100						100,000						28,150						780,801
Sales and marketing			272,302						241,880						786,265						687,896
General and administrative			56,779						67,329						199,529						227,551
(Gain) loss on change in fair value of acquisition-related contingent consideration			(12,204)						23,410						22,129						23,847
(Profit) and loss sharing under collaboration agreements			—						—						—						(1,025)
Other segment items4			19,349						39,629						191,629						(71,550)
Net income (loss)			$	424,169					$	106,456					$	987,371					$	(168,597)

1.Research and development - internal is comprised of internally generated costs such as salaries, travel, regulatory costs, lab costs, contracting, etc.

2.Research and development - external is comprised of specific program spend with external vendors (i.e. contract manufacturing organizations, contract research organizations and lab vendors for clinical, technical operations and toxicology services).

3.Other research and development is comprised of all other costs including certain one-time costs resulting from the acquisition of IPR&D assets and one-time development milestone expenses.

4.Other segment items is comprised of interest income, interest expense, realized and unrealized (gain) loss on equity investments, other, net, and provision for income taxes

Schedule of Revenue from External Customers by Geographic Areas

Total revenues by geographic region consisted of the following (in thousands):

			Three Months Ended September 30,												Nine Months Ended September 30,
			2025						2024						2025						2024
United States			$	1,261,261					$	1,070,040					$	3,375,171					$	2,887,233
Europe			100,306						66,464						247,744						171,581
Other countries			4,413						1,367						11,492						3,705
Total revenues			$	1,365,980					$	1,137,871					$	3,634,407					$	3,062,519

Schedule of Long-Lived Assets by Geographic Areas

Property and equipment, net by geographic location was as follows (in thousands):

			September 30, 2025						December 31, 2024
United States			$	477,059					$	474,095
Switzerland			308,107						277,623
Other countries			13,468						11,693
Total property and equipment, net			$	798,634					$	763,411

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- Definition

Tabular disclosure of long-lived assets, excluding financial instruments, long-term customer relationships of a financial institution, mortgage rights, deferred policy acquisition costs, and deferred tax assets, by geographic areas located in the entity's country of domicile and foreign countries in which the entity holds assets.

+ References

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-Topic 280
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-Name Accounting Standards Codification
-Section 50
-Paragraph 41
-Subparagraph (b)
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Tabular disclosure of revenue from external customers by geographic areas attributed to the entity's country of domicile and to foreign countries from which the entity derives revenue.

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Tabular disclosure of the profit or loss and total assets for each reportable segment. An entity discloses certain information on each reportable segment if the amounts (a) are included in the measure of segment profit or loss reviewed by the chief operating decision maker or (b) are otherwise regularly provided to the chief operating decision maker, even if not included in that measure of segment profit or loss.

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