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License Agreements - Syndax (Details) - USD ($) $ in Thousands	1 Months Ended		3 Months Ended		9 Months Ended		49 Months Ended
	Aug. 31, 2024	Sep. 30, 2021	Sep. 30, 2025	Sep. 30, 2024	Sep. 30, 2025	Sep. 30, 2024	Sep. 30, 2025	Dec. 31, 2024
License Agreements
Long term equity investments			$ 21,870		$ 21,870		$ 21,870	$ 18,814	[1]
Research and development			$ 506,584	$ 573,174	$ 1,438,780	$ 2,140,814
Investment in Syndax
License Agreements
Common stock held from investment (in shares)			1,400,000		1,400,000		1,400,000
Long term equity investments			$ 21,900		$ 21,900		$ 21,900	18,800
Gain (loss) on equity investments			8,600	(1,900)	3,100	(3,400)
Syndax
License Agreements
Upfront payment under license agreement							129,500
Research and development			6,300	$ 5,800	16,300	$ 17,600
Accrued and other liabilities			$ 1,700		$ 1,700		1,700	$ 2,200
Syndax | United States | Syndax
License Agreements
Funding of future development costs (as a percent)		45.00%
Syndax | Incyte
License Agreements
Funding of future development costs (as a percent)			55.00%	55.00%	55.00%	55.00%
Syndax | Incyte | United States
License Agreements
Funding of future development costs (as a percent)		55.00%
Syndax | Regulatory Milestone
License Agreements
Milestone payment made under license agreement	$ 12,500
Milestone payment, estimated useful life (in years)	10 years
Syndax | Development and Regulatory Milestones | Maximum
License Agreements
Additional milestone payments under the license agreement			$ 207,500		$ 207,500		207,500
Syndax | Commercialization Milestones | Maximum
License Agreements
Additional milestone payments under the license agreement			$ 230,000		$ 230,000		$ 230,000
[1] The condensed consolidated balance sheet at December 31, 2024 has been derived from the audited consolidated financial statements at that date.

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