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Segment Reporting - Schedule of Consolidated Net Income (Details) - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2025
Jun. 30, 2025
Mar. 31, 2025
Sep. 30, 2024
Jun. 30, 2024
Mar. 31, 2024
Sep. 30, 2025
Sep. 30, 2024
Revenues from External Customers and Long-Lived Assets [Line Items]                
Total revenues $ 1,365,980     $ 1,137,871     $ 3,634,407 $ 3,062,519
Costs, expenses and other:                
Cost of product revenues (including definite-lived intangible amortization) 99,001     85,993     250,955 223,583
Contract dispute settlement 0     0     (242,251) 0
(Gain) loss on change in fair value of acquisition-related contingent consideration (12,204)     23,410     22,129 23,847
(Profit) and loss sharing under collaboration agreements 0     0     0 (1,025)
Net income (loss) 424,169 $ 404,999 $ 158,203 106,456 $ (444,601) $ 169,548 987,371 (168,597)
Reportable Segment                
Revenues from External Customers and Long-Lived Assets [Line Items]                
Total revenues 1,365,980     1,137,871     3,634,407 3,062,519
Costs, expenses and other:                
Cost of product revenues (including definite-lived intangible amortization) 99,001     85,993     250,955 223,583
Contract dispute settlement 0     0     (242,251) 0
Research and development - internal 250,140     250,477     715,171 707,208
Research and development - external 256,344     222,697     695,459 652,805
Other research and development 100     100,000     28,150 780,801
Sales and marketing 272,302     241,880     786,265 687,896
General and administrative 56,779     67,329     199,529 227,551
(Gain) loss on change in fair value of acquisition-related contingent consideration (12,204)     23,410     22,129 23,847
(Profit) and loss sharing under collaboration agreements 0     0     0 (1,025)
Other segment items 19,349     39,629     191,629 (71,550)
Net income (loss) 424,169     106,456     987,371 (168,597)
Product revenues, net                
Revenues from External Customers and Long-Lived Assets [Line Items]                
Total revenues 1,149,856     962,992     3,131,544 2,599,481
Product revenues, net | Reportable Segment                
Revenues from External Customers and Long-Lived Assets [Line Items]                
Total revenues 1,149,856     962,992     3,131,544 2,599,481
Product royalty revenues                
Revenues from External Customers and Long-Lived Assets [Line Items]                
Total revenues 171,124     156,879     452,863 420,038
Product royalty revenues | Reportable Segment                
Revenues from External Customers and Long-Lived Assets [Line Items]                
Total revenues 171,124     156,879     452,863 420,038
Milestone and contract revenues                
Revenues from External Customers and Long-Lived Assets [Line Items]                
Total revenues 45,000     18,000     50,000 43,000
Milestone and contract revenues | Reportable Segment                
Revenues from External Customers and Long-Lived Assets [Line Items]                
Total revenues $ 45,000     $ 18,000     $ 50,000 $ 43,000