v3.25.4

Collaborative and Other Relationships - Prelude (Details) - USD ($) $ / shares in Units, $ in Thousands | 1 Months Ended | 12 Months Ended
--- | --- | ---
Nov. 30, 2025 | Dec. 31, 2025 | Dec. 31, 2024 | Dec. 31, 2023
License agreements |  |  |  |
Research and development |  | $ 2,050,152 | $ 2,606,848 | $ 1,627,594
Long term equity investments |  | 47,991 | $ 18,814 |
Investment in Prelude |  |  |  |
License agreements |  |  |  |
Payments to acquire equity securities | $ 25,000 |  |  |
Investment owned (in shares) | 6,250,000 |  |  |
Non-voting common stock (in dollars per share) | $ 4.00 |  |  |
Long term equity investments | $ 7,900 | 18,100 |  |
Unrealized gain on equity investments |  | $ 10,300 |  |
Prelude |  |  |  |
License agreements |  |  |  |
Payment to acquire license agreement | 60,000 |  |  |
Upfront payment under license agreement | 35,000 |  |  |
Research and development | 17,100 |  |  |
Milestone payment made under license agreement | 100,000 |  |  |
Prelude | Clinical And Regulatory Milestones And Single Digit Royalties On Global Net Sales | Maximum |  |  |  |
License agreements |  |  |  |
Additional milestone payments under the license agreement | $ 775,000 |  |  |

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