v3.25.4

Collaborative and Other Relationships - Lily (Details) - USD ($) $ in Thousands | 1 Months Ended | 12 Months Ended | 193 Months Ended
--- | --- | --- | ---
Oct. 31, 2025 | Dec. 31, 2009 | Dec. 31, 2025 | Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2025
License agreements |  |  |  |  |  |
Total revenues |  |  | $ 5,141,242 | $ 4,241,217 | $ 3,695,649 |
Eli Lilly |  |  |  |  |  |
License agreements |  |  |  |  |  |
Upfront payment received under license agreement | $ 100,000 |  |  |  |  | $ 100,000
Eli Lilly | OLUMIANT |  |  |  |  |  |
License agreements |  |  |  |  |  |
Total revenues |  |  | $ 144,600 | $ 135,600 | $ 136,100 |
Development Milestones | Eli Lilly |  |  |  |  |  |
License agreements |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  | 149,000
Development Milestones | Maximum | Eli Lilly |  |  |  |  |  |
License agreements |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  | $ 150,000 |  |  |  |
Regulatory Milestones | Eli Lilly |  |  |  |  |  |
License agreements |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  | 335,000
Regulatory Milestones | Maximum | Eli Lilly |  |  |  |  |  |
License agreements |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  | 365,000 |  |  |  |
Commercialization Milestones | Eli Lilly |  |  |  |  |  |
License agreements |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  | $ 50,000
Commercialization Milestones | Maximum | Eli Lilly |  |  |  |  |  |
License agreements |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  | $ 150,000 |  |  |  |

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