v3.25.4

Collaborative and Other Relationships - Syndax (Details) - USD ($) $ in Thousands | 1 Months Ended | 12 Months Ended | 52 Months Ended
--- | --- | --- | ---
Aug. 31, 2024 | Sep. 30, 2021 | Dec. 31, 2025 | Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2025
License agreements |  |  |  |  |  |
Long term equity investments |  |  | $ 47,991 | $ 18,814 |  | $ 47,991
Research and development |  |  | 2,050,152 | 2,606,848 | $ 1,627,594 |
Cost of product revenues (including definite-lived intangible amortization) |  |  | $ 372,130 | 312,068 | 254,990 |
Investment in Syndax |  |  |  |  |  |
License agreements |  |  |  |  |  |
Investment owned (in shares) |  |  | 1,400,000 |  |  | 1,400,000
Long term equity investments |  |  | $ 29,900 | 18,800 |  | $ 29,900
Unrealized gain (loss) on equity investments |  |  | 11,100 | (11,900) | $ (5,500) |
Syndax |  |  |  |  |  |
License agreements |  |  |  |  |  |
Upfront payment under license agreement |  |  |  |  |  | 129,500
Research and development |  |  | 21,900 | 18,800 |  |
Syndax | Axatilimab - Development Activities |  |  |  |  |  |
License agreements |  |  |  |  |  |
Accrued and other liabilities |  |  | 2,400 | $ 2,200 |  | 2,400
Syndax | Regulatory Milestone |  |  |  |  |  |
License agreements |  |  |  |  |  |
Milestone payment made under license agreement | $ 12,500 |  |  |  |  |
Milestone payment, estimated useful life | 10 years |  |  |  |  |
Syndax | Development and Regulatory Milestones | Maximum |  |  |  |  |  |
License agreements |  |  |  |  |  |
Additional milestone payments under the license agreement |  |  | 207,500 |  |  | 207,500
Syndax | Commercialization Milestones | Maximum |  |  |  |  |  |
License agreements |  |  |  |  |  |
Additional milestone payments under the license agreement |  |  | $ 225,000 |  |  | 225,000
Syndax | Incyte |  |  |  |  |  |
License agreements |  |  |  |  |  |
Funding of future development costs |  |  | 55.00% | 55.00% |  |
Syndax | United States |  |  |  |  |  |
License agreements |  |  |  |  |  |
Profit share percentage from co-commercialization efforts |  |  | 50.00% |  |  |
Cost of product revenues (including definite-lived intangible amortization) |  |  | $ 44,000 |  |  |
Syndax | United States | Axatilimab - Commercialization Activities |  |  |  |  |  |
License agreements |  |  |  |  |  |
Accrued and other liabilities |  |  | $ 27,600 |  |  | $ 27,600
Syndax | United States | Syndax |  |  |  |  |  |
License agreements |  |  |  |  |  |
Funding of future development costs |  | 45.00% |  |  |  |
Syndax | United States | Incyte |  |  |  |  |  |
License agreements |  |  |  |  |  |
Funding of future development costs |  | 55.00% |  |  |  |

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