Stockholders' Equity (Tables)

12 Months Ended

Dec. 31, 2025

Stockholders' Equity Note [Abstract]

Schedule of Option Activity Under the 2010 Stock Plan

Option activity under the 2010 Stock Plan and 2024 Inducement Plan was as follows:


	Shares Subject to Outstanding Options
	Shares	Weighted Average Exercise Price
Balance at December 31, 2024	12,777,974	$	83.45
Options granted	1,418,018	$	72.72
Options exercised	(2,585,198)	$	77.78
Options cancelled	(750,933)	$	82.58
Balance at December 31, 2025	10,859,861	$	83.46

Schedule of Stock Options Outstanding and Exercisable by Exercise Price Range

The following table summarizes information about stock options outstanding as of December 31, 2025 under the 2010 Stock Plan and 2024 Inducement Plan:


	Options Outstanding				Options Exercisable
Range of Exercise Prices	Number Outstanding	Weighted Average Remaining Contractual Life (in years)	Weighted Average Exercise Price		Number Exercisable	Weighted Average Exercise Price
$52.94 - $61.76	1,147,054	7.3	$	60.83	720,211	$	60.91
$62.03 - $68.62	1,477,011	7.1	66.70		642,215	67.16
$68.70 - $72.27	1,275,187	6.1	71.69		786,369	71.94
$72.66 - $77.67	1,112,675	5.8	75.63		1,012,061	75.54
$77.83 - $83.58	1,603,241	5.1	82.25		1,540,401	82.25
$83.83 - $90.56	1,456,611	3.9	86.66		1,347,601	86.78
$90.92 - $106.47	1,523,552	3.5	100.00		1,456,431	99.91
$113.64 - $128.34	1,149,228	1.2	118.77		1,149,228	118.77
$132.00 - $134.38	97,860	1.2	134.02		97,860	134.02
$138.52 - $138.52	17,442	1.3	138.52		17,442	138.52
	10,859,861				8,769,819

Schedule of RSU Award and PSU Activity

RSU and PSU award activity under the 2010 Stock Plan and 2024 Inducement Plan was as follows:


	Shares Subject to Outstanding Awards
	Shares	Grant Date Value
Balance at December 31, 2024	8,656,803	$	67.81
RSUs granted	3,492,732	$	69.24
PSUs granted	897,393	$	59.00
Additional PSUs earned	32,148	$	70.45
RSUs released	(2,860,640)	$	70.86
PSUs released	(255,805)	$	72.97
RSUs cancelled	(543,681)	$	67.19
PSUs cancelled	(143,500)	$	76.73
Balance at December 31, 2025	9,275,450	$	66.86

Schedule of Shares Available for Grant

The following table summarizes our shares available for grant under the 2010 Plan and 2024 Inducement Plan. Previously, each RSU and PSU grant reduced the available share pool by 2 shares. In June 2025, our stockholders approved an amendment to the 2010 Stock Plan to remove the fungible ratio, and all awards granted under the 2010 Stock Plan after June 10, 2025, the date of our latest annual meeting, will reduce the share reserve on a one-for-one basis. If awards granted under the 2010 Stock Plan on or prior to June 10, 2025 expire, become unexercisable or are forfeited or repurchased after that date, the shares that were subject to those awards will become available for future grant only on a one-for-one basis, even if the original award was a full value award that reduced the share reserve on a two-for-one basis. The 2024 Inducement Plan was amended in June 2025 to remove the provision that stated that any shares issued in connection with awards other than options and stock appreciation rights will be counted against the authorized share limitation as 2.0 shares for every one share so issued and, as a result, all awards granted under the 2024 Inducement Plan will reduce the share reserve thereunder on a one-for-one basis.


			Shares Available for Grant
Balance at December 31, 2024			4,013,611
Additional authorization - 2010 Stock Plan			8,500,000
Additional authorization - 2024 Inducement Plan			1,000,000
Options, RSUs and PSUs granted and issuance of shares for services rendered			(6,335,986)
Options, RSUs and PSUs cancelled			1,598,684
Fungible ratio change adjustments			282,731
Balance at December 31, 2025			9,059,040