v3.25.4

Collaborative and Other Relationships - Syndax (Details) - USD ($) $ in Thousands	1 Months Ended		12 Months Ended			52 Months Ended
	Aug. 31, 2024	Sep. 30, 2021	Dec. 31, 2025	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2025
License agreements
Long term equity investments			$ 47,991	$ 18,814		$ 47,991
Research and development			2,050,152	2,606,848	$ 1,627,594
Cost of product revenues (including definite-lived intangible amortization)			$ 372,130	312,068	254,990
Investment in Syndax
License agreements
Investment owned (in shares)			1,400,000			1,400,000
Long term equity investments			$ 29,900	18,800		$ 29,900
Unrealized gain (loss) on equity investments			11,100	(11,900)	$ (5,500)
Syndax
License agreements
Upfront payment under license agreement						129,500
Research and development			21,900	18,800
Syndax | Axatilimab - Development Activities
License agreements
Accrued and other liabilities			2,400	$ 2,200		2,400
Syndax | Regulatory Milestone
License agreements
Milestone payment made under license agreement	$ 12,500
Milestone payment, estimated useful life	10 years
Syndax | Development and Regulatory Milestones | Maximum
License agreements
Additional milestone payments under the license agreement			207,500			207,500
Syndax | Commercialization Milestones | Maximum
License agreements
Additional milestone payments under the license agreement			$ 225,000			225,000
Syndax | Incyte
License agreements
Funding of future development costs			55.00%	55.00%
Syndax | United States
License agreements
Profit share percentage from co-commercialization efforts			50.00%
Cost of product revenues (including definite-lived intangible amortization)			$ 44,000
Syndax | United States | Axatilimab - Commercialization Activities
License agreements
Accrued and other liabilities			$ 27,600			$ 27,600
Syndax | United States | Syndax
License agreements
Funding of future development costs		45.00%
Syndax | United States | Incyte
License agreements
Funding of future development costs		55.00%

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