v3.25.4

Stockholders' Equity - Narrative (Details) - USD ($)			1 Months Ended		5 Months Ended	12 Months Ended
	Jun. 26, 2024	Jun. 13, 2024	Jun. 30, 2025	Jun. 30, 2024	May 31, 2025	Dec. 31, 2025	Dec. 31, 2024	Dec. 31, 2023	Jul. 31, 2025	May 14, 2024	May 13, 2024	May 12, 2024	May 09, 2024
Stock compensation
Preferred stock, shares authorized (in shares)						5,000,000	5,000,000
Preferred stock, shares outstanding (in shares)						0	0
Common stock, shares authorized (in shares)						400,000,000	400,000,000
Stock repurchased (in shares)				33,325,849
Shares acquired, average cost per share (in dollars per share)				$ 60.00
Repurchase of common stock				$ 2,000,000,000.0
Share repurchase, fees and expenses				24,400,000
Share repurchase program, excise tax				$ 19,100,000
Shares reserved for future issuance related to stock plans (in shares)						9,949,772
Options exercisable and vested (in shares)						8,769,819	10,381,128	9,743,775
Intrinsic value of options exercised						$ 41,800,000	$ 3,200,000	$ 3,200,000
Intrinsic value of options outstanding						198,300,000
Intrinsic value of vested options						195,800,000
Stock compensation expense						$ 249,300,000	$ 266,100,000	$ 215,900,000
Number of shares available for grant for each award granted (in shares)			1		2
Issuance of shares of Common Stock under the ESPP (in shares)						398,373	453,312	380,145
Remaining shares available (in shares)						9,059,040	4,013,611
Employee Stock
Stock compensation
Shares reserved for future issuance related to stock plans (in shares)			11,350,000		10,350,000
Stock compensation expense						$ 6,000,000.0	$ 5,300,000	$ 5,100,000
Employment period for eligibility to participate in the plan						1 month
Issuance of shares of Common Stock under the ESPP (in shares)						398,373	453,312	380,145
Remaining shares available (in shares)						890,732
Options
Stock compensation
Vesting period (in years)						4 years
Options | Share-based Payment Arrangement, Tranche One
Stock compensation
Vesting period (in years)						1 year
Percentage of units vesting at the end of each calendar year (as a percent)						25.00%
Options | Share-based Payment Arrangement, Tranche Two
Stock compensation
Vesting period (in years)						36 months
Restricted Stock Units (RSUs)
Stock compensation
Vesting period (in years)						4 years
Percentage of units vesting at the end of each calendar year (as a percent)						25.00%
Number of shares awarded for each RSU (in shares)						1
Performance Shares
Stock compensation
Vesting period (in years)						4 years
Stock compensation expense						$ 19,700,000	$ 30,100,000	$ 17,200,000
Non-employee Director | Options
Stock compensation
Expiration period (in years)						10 years
Stock Incentive Plan 2010
Stock compensation
Shares reserved for future issuance related to stock plans (in shares)			74,953,475		66,453,475
2024 Inducement Plan
Stock compensation
Shares reserved for future issuance related to stock plans (in shares)			1,000,000						2,000,000
Incyte | Baker Entities
Stock compensation
Subsidiary, ownership percentage, noncontrolling owner (as percent)													16.40%
Maximum | Performance Shares
Stock compensation
Vesting period (in years)						6 years
Minimum | Employee Stock
Stock compensation
Number of employee working hours per week for eligibility to participate in the plan						20 hours
Minimum | Performance Shares
Stock compensation
Vesting period (in years)						3 years
Board of Directors Approved Share Repurchase Program
Stock compensation
Share repurchase program, authorized, amount											$ 2,000,000,000.0
Dutch Auction Tender Offer
Stock compensation
Share repurchase program, authorized, amount										$ 1,672,000,000
Stock repurchased (in shares)		27,866,666
Shares acquired, average cost per share (in dollars per share)		$ 60.00
Repurchase of common stock		$ 1,672,000,000
Dutch Auction Tender Offer | Maximum
Stock compensation
Share repurchase program, tender offer (in dollars per share)											$ 60.00
Dutch Auction Tender Offer | Minimum
Stock compensation
Share repurchase program, tender offer (in dollars per share)											$ 52.00
Baker Entities Share Repurchase Program
Stock compensation
Share repurchase program, authorized, amount												$ 328,000,000
Stock repurchased (in shares)	5,459,183
Shares acquired, average cost per share (in dollars per share)	$ 60.00
Repurchase of common stock	$ 328,000,000

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