v3.25.4
Segment Reporting - Schedule of Consolidated Net Income (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2025
Dec. 31, 2024
Dec. 31, 2023
Revenues from External Customers and Long-Lived Assets [Line Items]      
Total revenues $ 5,141,242 $ 4,241,217 $ 3,695,649
Costs, expenses and other:      
Cost of product revenues (including definite-lived intangible amortization) 372,130 312,068 254,990
Contract dispute settlement (242,251) 0 0
Asset impairment 76,275 0 5,631
(Gain) loss on change in fair value of acquisition-related contingent consideration (6,129) 19,803 29,202
(Profit) and loss sharing under collaboration agreements 0 (1,025) 2,045
Net income 1,286,650 32,615 597,599
Reportable Segment      
Revenues from External Customers and Long-Lived Assets [Line Items]      
Total revenues 5,141,242 4,241,217 3,695,649
Costs, expenses and other:      
Cost of product revenues (including definite-lived intangible amortization) 372,130 312,068 254,990
Contract dispute settlement (242,251) 0 0
Research and development - internal 984,730 957,043 815,025
Research and development - external 967,848 866,005 775,919
Other research and development 97,574 783,800 36,650
Sales and marketing 1,094,754 945,428 876,703
General and administrative 281,452 296,729 278,959
Asset impairment 76,275 0 5,631
(Gain) loss on change in fair value of acquisition-related contingent consideration (6,129) 19,803 29,202
(Profit) and loss sharing under collaboration agreements 0 (1,025) 2,045
Other segment items 228,209 28,751 22,926
Net income 1,286,650 32,615 597,599
Product revenues, net      
Revenues from External Customers and Long-Lived Assets [Line Items]      
Total revenues 4,354,333 3,618,888 3,165,168
Product revenues, net | Reportable Segment      
Revenues from External Customers and Long-Lived Assets [Line Items]      
Total revenues 4,354,333 3,618,888 3,165,168
Product royalty revenues      
Revenues from External Customers and Long-Lived Assets [Line Items]      
Total revenues 636,909 579,329 523,481
Product royalty revenues | Reportable Segment      
Revenues from External Customers and Long-Lived Assets [Line Items]      
Total revenues 636,909 579,329 523,481
Milestone and contract revenues      
Revenues from External Customers and Long-Lived Assets [Line Items]      
Total revenues 150,000 43,000 7,000
Milestone and contract revenues | Reportable Segment      
Revenues from External Customers and Long-Lived Assets [Line Items]      
Total revenues $ 150,000 $ 43,000 $ 7,000