<?xml version="1.0" encoding="US-ASCII"?>
<!--XBRL Document Created with Wdesk from Workiva, formerly WebFilings-->
<!-- -->
<xsd:schema attributeFormDefault="unqualified" elementFormDefault="qualified" targetNamespace="http://www.hologic.com/20150328" xmlns:holx="http://www.hologic.com/20150328" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric" xmlns:num="http://www.xbrl.org/dtr/type/numeric" xmlns:us-types="http://fasb.org/us-types/2014-01-31" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsd="http://www.w3.org/2001/XMLSchema">
  <xsd:import namespace="http://fasb.org/us-gaap/2014-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd" />
  <xsd:import namespace="http://fasb.org/us-roles/2014-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2014/elts/us-roles-2014-01-31.xsd" />
  <xsd:import namespace="http://fasb.org/us-types/2014-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2014/elts/us-types-2014-01-31.xsd" />
  <xsd:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd" />
  <xsd:import namespace="http://www.xbrl.org/2003/linkbase" schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" />
  <xsd:import namespace="http://www.xbrl.org/2009/arcrole/fact-explanatoryFact" schemaLocation="http://www.xbrl.org/lrr/arcrole/factExplanatory-2009-12-16.xsd" />
  <xsd:import namespace="http://www.xbrl.org/2009/role/negated" schemaLocation="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd" />
  <xsd:import namespace="http://www.xbrl.org/2009/role/net" schemaLocation="http://www.xbrl.org/lrr/role/net-2009-12-16.xsd" />
  <xsd:import namespace="http://www.xbrl.org/dtr/type/non-numeric" schemaLocation="http://www.xbrl.org/dtr/type/nonNumeric-2009-12-16.xsd" />
  <xsd:import namespace="http://www.xbrl.org/dtr/type/numeric" schemaLocation="http://www.xbrl.org/dtr/type/numeric-2009-12-16.xsd" />
  <xsd:import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd" />
  <xsd:import namespace="http://xbrl.sec.gov/country/2013-01-31" schemaLocation="http://xbrl.sec.gov/country/2013/country-2013-01-31.xsd" />
  <xsd:import namespace="http://xbrl.sec.gov/currency/2014-01-31" schemaLocation="http://xbrl.sec.gov/currency/2014/currency-2014-01-31.xsd" />
  <xsd:import namespace="http://xbrl.sec.gov/dei/2014-01-31" schemaLocation="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd" />
  <xsd:import namespace="http://xbrl.sec.gov/exch/2014-01-31" schemaLocation="http://xbrl.sec.gov/exch/2014/exch-2014-01-31.xsd" />
  <xsd:import namespace="http://xbrl.sec.gov/invest/2013-01-31" schemaLocation="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd" />
  <xsd:import namespace="http://xbrl.sec.gov/naics/2011-01-31" schemaLocation="http://xbrl.sec.gov/naics/2011/naics-2011-01-31.xsd" />
  <xsd:import namespace="http://xbrl.sec.gov/sic/2011-01-31" schemaLocation="http://xbrl.sec.gov/sic/2011/sic-2011-01-31.xsd" />
  <xsd:import namespace="http://xbrl.sec.gov/stpr/2011-01-31" schemaLocation="http://xbrl.sec.gov/stpr/2011/stpr-2011-01-31.xsd" />
  <xsd:annotation>
    <xsd:appinfo>
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="holx-20150328_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:type="simple" />
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="holx-20150328_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:type="simple" />
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="holx-20150328_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:type="simple" />
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="holx-20150328_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:type="simple" />
      <link:roleType id="BasisOfPresentation" roleURI="http://www.hologic.com/role/BasisOfPresentation">
        <link:definition>2101100 - Disclosure - Basis of Presentation</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BorrowingsAndCreditArrangements" roleURI="http://www.hologic.com/role/BorrowingsAndCreditArrangements">
        <link:definition>2104100 - Disclosure - Borrowings and Credit Arrangements</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BorrowingsAndCreditArrangementsAdditionalInformationDetail" roleURI="http://www.hologic.com/role/BorrowingsAndCreditArrangementsAdditionalInformationDetail">
        <link:definition>2404403 - Disclosure - Borrowings and Credit Arrangements - Additional Information (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BorrowingsAndCreditArrangementsCompanysBorrowingsDetail" roleURI="http://www.hologic.com/role/BorrowingsAndCreditArrangementsCompanysBorrowingsDetail">
        <link:definition>2404402 - Disclosure - Borrowings and Credit Arrangements - Company's Borrowings (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BorrowingsAndCreditArrangementsInterestExpenseUnderConvertibleNotesDetail" roleURI="http://www.hologic.com/role/BorrowingsAndCreditArrangementsInterestExpenseUnderConvertibleNotesDetail">
        <link:definition>2404404 - Disclosure - Borrowings and Credit Arrangements - Interest Expense under Convertible Notes (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BorrowingsAndCreditArrangementsTables" roleURI="http://www.hologic.com/role/BorrowingsAndCreditArrangementsTables">
        <link:definition>2304301 - Disclosure - Borrowings and Credit Arrangements (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BusinessSegmentsAndGeographicInformation" roleURI="http://www.hologic.com/role/BusinessSegmentsAndGeographicInformation">
        <link:definition>2112100 - Disclosure - Business Segments and Geographic Information</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BusinessSegmentsAndGeographicInformationAdditionalInformationDetail" roleURI="http://www.hologic.com/role/BusinessSegmentsAndGeographicInformationAdditionalInformationDetail">
        <link:definition>2412402 - Disclosure - Business Segments and Geographic Information - Additional Information (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BusinessSegmentsAndGeographicInformationRevenuesByGeographyDetail" roleURI="http://www.hologic.com/role/BusinessSegmentsAndGeographicInformationRevenuesByGeographyDetail">
        <link:definition>2412404 - Disclosure - Business Segments and Geographic Information - Revenues by Geography (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BusinessSegmentsAndGeographicInformationSegmentInformationDetail" roleURI="http://www.hologic.com/role/BusinessSegmentsAndGeographicInformationSegmentInformationDetail">
        <link:definition>2412403 - Disclosure - Business Segments and Geographic Information - Segment Information (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BusinessSegmentsAndGeographicInformationTables" roleURI="http://www.hologic.com/role/BusinessSegmentsAndGeographicInformationTables">
        <link:definition>2312301 - Disclosure - Business Segments and Geographic Information (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CommitmentsAndContingencies" roleURI="http://www.hologic.com/role/CommitmentsAndContingencies">
        <link:definition>2107100 - Disclosure - Commitments and Contingencies</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CommitmentsAndContingenciesAdditionalInformationDetail" roleURI="http://www.hologic.com/role/CommitmentsAndContingenciesAdditionalInformationDetail">
        <link:definition>2407401 - Disclosure - Commitments and Contingencies - Additional Information (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ConsolidatedBalanceSheets" roleURI="http://www.hologic.com/role/ConsolidatedBalanceSheets">
        <link:definition>1003000 - Statement - Consolidated Balance Sheets</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ConsolidatedBalanceSheetsParenthetical" roleURI="http://www.hologic.com/role/ConsolidatedBalanceSheetsParenthetical">
        <link:definition>1003501 - Statement - Consolidated Balance Sheets (Parenthetical)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ConsolidatedStatementsOfCashFlows" roleURI="http://www.hologic.com/role/ConsolidatedStatementsOfCashFlows">
        <link:definition>1004000 - Statement - Consolidated Statements of Cash Flows</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ConsolidatedStatementsOfComprehensiveIncomeLoss" roleURI="http://www.hologic.com/role/ConsolidatedStatementsOfComprehensiveIncomeLoss">
        <link:definition>1002000 - Statement - Consolidated Statements of Comprehensive Income (Loss)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ConsolidatedStatementsOfComprehensiveIncomeLossParenthetical" roleURI="http://www.hologic.com/role/ConsolidatedStatementsOfComprehensiveIncomeLossParenthetical">
        <link:definition>1002501 - Statement - Consolidated Statements of Comprehensive Income (Loss) (Parenthetical)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ConsolidatedStatementsOfOperations" roleURI="http://www.hologic.com/role/ConsolidatedStatementsOfOperations">
        <link:definition>1001000 - Statement - Consolidated Statements of Operations</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DerivativesAdditionalInformationDetails" roleURI="http://www.hologic.com/role/DerivativesAdditionalInformationDetails">
        <link:definition>2405403 - Disclosure - Derivatives Additional Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DerivativesNotes" roleURI="http://www.hologic.com/role/DerivativesNotes">
        <link:definition>2105100 - Disclosure - Derivatives (Notes)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DerivativesScheduleOfDerivativeInstrumentsOnConsolidatedBalanceSheetsAndUnrealizedLossRecognizedInAociDetails" roleURI="http://www.hologic.com/role/DerivativesScheduleOfDerivativeInstrumentsOnConsolidatedBalanceSheetsAndUnrealizedLossRecognizedInAociDetails">
        <link:definition>2405402 - Disclosure - Derivatives Schedule of Derivative Instruments on the Consolidated Balance Sheets and Unrealized Loss Recognized in AOCI (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DerivativesTables" roleURI="http://www.hologic.com/role/DerivativesTables">
        <link:definition>2305301 - Disclosure - Derivatives (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DocumentAndEntityInformation" roleURI="http://www.hologic.com/role/DocumentAndEntityInformation">
        <link:definition>0001000 - Document - Document and Entity Information</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueMeasurements" roleURI="http://www.hologic.com/role/FairValueMeasurements">
        <link:definition>2102100 - Disclosure - Fair Value Measurements</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueMeasurementsAdditionalInformationDetail" roleURI="http://www.hologic.com/role/FairValueMeasurementsAdditionalInformationDetail">
        <link:definition>2402403 - Disclosure - Fair Value Measurements - Additional Information (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueMeasurementsEstimatedFairValuesOfConvertibleNotesDetail" roleURI="http://www.hologic.com/role/FairValueMeasurementsEstimatedFairValuesOfConvertibleNotesDetail">
        <link:definition>2402404 - Disclosure - Fair Value Measurements - Estimated Fair Values of Convertible Notes (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueMeasurementsFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisDetail" roleURI="http://www.hologic.com/role/FairValueMeasurementsFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisDetail">
        <link:definition>2402402 - Disclosure - Fair Value Measurements - Fair Value Assets and Liabilities Measured on Recurring Basis (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueMeasurementsTables" roleURI="http://www.hologic.com/role/FairValueMeasurementsTables">
        <link:definition>2302301 - Disclosure - Fair Value Measurements (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IncomeTaxes" roleURI="http://www.hologic.com/role/IncomeTaxes">
        <link:definition>2113100 - Disclosure - Income Taxes</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IncomeTaxesAdditionalInformationDetail" roleURI="http://www.hologic.com/role/IncomeTaxesAdditionalInformationDetail">
        <link:definition>2413401 - Disclosure - Income Taxes - Additional Information (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IntangibleAssets" roleURI="http://www.hologic.com/role/IntangibleAssets">
        <link:definition>2114100 - Disclosure - Intangible Assets</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IntangibleAssetsAdditionalInformationDetail" roleURI="http://www.hologic.com/role/IntangibleAssetsAdditionalInformationDetail">
        <link:definition>2414403 - Disclosure - Intangible Assets - Additional Information (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IntangibleAssetsScheduleOfEstimatedAmortizationExpenseDetail" roleURI="http://www.hologic.com/role/IntangibleAssetsScheduleOfEstimatedAmortizationExpenseDetail">
        <link:definition>2414404 - Disclosure - Intangible Assets - Schedule of Estimated Amortization Expense (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IntangibleAssetsScheduleOfIntangibleAssetsDetail" roleURI="http://www.hologic.com/role/IntangibleAssetsScheduleOfIntangibleAssetsDetail">
        <link:definition>2414402 - Disclosure - Intangible Assets - Schedule of Intangible Assets (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IntangibleAssetsTables" roleURI="http://www.hologic.com/role/IntangibleAssetsTables">
        <link:definition>2314301 - Disclosure - Intangible Assets (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="MarketableSecurities" roleURI="http://www.hologic.com/role/MarketableSecurities">
        <link:definition>2108100 - Disclosure - Marketable Securities</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="MarketableSecuritiesReconcilesCostBasisToFairMarketValueOfCompanysEquitySecurityDetail" roleURI="http://www.hologic.com/role/MarketableSecuritiesReconcilesCostBasisToFairMarketValueOfCompanysEquitySecurityDetail">
        <link:definition>2408402 - Disclosure - Marketable Securities - Reconciles Cost Basis to Fair Market Value of Company's Equity Security (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="MarketableSecuritiesTables" roleURI="http://www.hologic.com/role/MarketableSecuritiesTables">
        <link:definition>2308301 - Disclosure - Marketable Securities (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NetIncomeLossPerShare" roleURI="http://www.hologic.com/role/NetIncomeLossPerShare">
        <link:definition>2109100 - Disclosure - Net Income (Loss) Per Share</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NetIncomeLossPerShareReconciliationOfBasicAndDilutedShareAmountsDetail" roleURI="http://www.hologic.com/role/NetIncomeLossPerShareReconciliationOfBasicAndDilutedShareAmountsDetail">
        <link:definition>2409402 - Disclosure - Net Income (Loss) Per Share - Reconciliation of Basic and Diluted Share Amounts (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NetIncomeLossPerShareTables" roleURI="http://www.hologic.com/role/NetIncomeLossPerShareTables">
        <link:definition>2309301 - Disclosure - Net Income (Loss) Per Share (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NewAccountingPronouncements" roleURI="http://www.hologic.com/role/NewAccountingPronouncements">
        <link:definition>2117100 - Disclosure - New Accounting Pronouncements</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NewAccountingPronouncementsPolicies" roleURI="http://www.hologic.com/role/NewAccountingPronouncementsPolicies">
        <link:definition>2217201 - Disclosure - New Accounting Pronouncements (Policies)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="OtherBalanceSheetInformation" roleURI="http://www.hologic.com/role/OtherBalanceSheetInformation">
        <link:definition>2111100 - Disclosure - Other Balance Sheet Information</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="OtherBalanceSheetInformationOtherBalanceSheetInformationOfInventoriesDetail" roleURI="http://www.hologic.com/role/OtherBalanceSheetInformationOtherBalanceSheetInformationOfInventoriesDetail">
        <link:definition>2411402 - Disclosure - Other Balance Sheet Information - Other Balance Sheet Information of Inventories (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="OtherBalanceSheetInformationOtherBalanceSheetInformationOfPropertyPlantAndEquipmentDetail" roleURI="http://www.hologic.com/role/OtherBalanceSheetInformationOtherBalanceSheetInformationOfPropertyPlantAndEquipmentDetail">
        <link:definition>2411403 - Disclosure - Other Balance Sheet Information - Other Balance Sheet Information of Property, Plant and Equipment (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="OtherBalanceSheetInformationTables" roleURI="http://www.hologic.com/role/OtherBalanceSheetInformationTables">
        <link:definition>2311301 - Disclosure - Other Balance Sheet Information (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ProductWarranties" roleURI="http://www.hologic.com/role/ProductWarranties">
        <link:definition>2116100 - Disclosure - Product Warranties</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ProductWarrantiesProductWarrantyDetail" roleURI="http://www.hologic.com/role/ProductWarrantiesProductWarrantyDetail">
        <link:definition>2416402 - Disclosure - Product Warranties - Product Warranty (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ProductWarrantiesTables" roleURI="http://www.hologic.com/role/ProductWarrantiesTables">
        <link:definition>2316301 - Disclosure - Product Warranties (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RestructuringAndDivestitureCharges" roleURI="http://www.hologic.com/role/RestructuringAndDivestitureCharges">
        <link:definition>2103100 - Disclosure - Restructuring and Divestiture Charges</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RestructuringAndDivestitureChargesAdditionalInformationDetail" roleURI="http://www.hologic.com/role/RestructuringAndDivestitureChargesAdditionalInformationDetail">
        <link:definition>2403404 - Disclosure - Restructuring and Divestiture Charges - Additional Information (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RestructuringAndDivestitureChargesChargesTakenRelatedToAccruedRestructuringActionsDetail" roleURI="http://www.hologic.com/role/RestructuringAndDivestitureChargesChargesTakenRelatedToAccruedRestructuringActionsDetail">
        <link:definition>2403403 - Disclosure - Restructuring and Divestiture Charges - Charges Taken Related to Accrued Restructuring Actions (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RestructuringAndDivestitureChargesChargesTakenRelatedToRestructuringActionsDetail" roleURI="http://www.hologic.com/role/RestructuringAndDivestitureChargesChargesTakenRelatedToRestructuringActionsDetail">
        <link:definition>2403402 - Disclosure - Restructuring and Divestiture Charges - Charges Taken Related to Restructuring Actions (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RestructuringAndDivestitureChargesTables" roleURI="http://www.hologic.com/role/RestructuringAndDivestitureChargesTables">
        <link:definition>2303301 - Disclosure - Restructuring and Divestiture Charges (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockBasedCompensation" roleURI="http://www.hologic.com/role/StockBasedCompensation">
        <link:definition>2110100 - Disclosure - Stock-Based Compensation</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockBasedCompensationAdditionalInformationDetail" roleURI="http://www.hologic.com/role/StockBasedCompensationAdditionalInformationDetail">
        <link:definition>2410403 - Disclosure - Stock-Based Compensation - Additional Information (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockBasedCompensationStockBasedCompensationExpenseInConsolidatedStatementsOfOperationsDetail" roleURI="http://www.hologic.com/role/StockBasedCompensationStockBasedCompensationExpenseInConsolidatedStatementsOfOperationsDetail">
        <link:definition>2410402 - Disclosure - Stock-Based Compensation - Stock-Based Compensation Expense in Consolidated Statements of Operations (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockBasedCompensationTables" roleURI="http://www.hologic.com/role/StockBasedCompensationTables">
        <link:definition>2310301 - Disclosure - Stock-Based Compensation (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockBasedCompensationWeightedAverageAssumptionsUtilizedToValueStockOptionsDetail" roleURI="http://www.hologic.com/role/StockBasedCompensationWeightedAverageAssumptionsUtilizedToValueStockOptionsDetail">
        <link:definition>2410404 - Disclosure - Stock-Based Compensation - Weighted-Average Assumptions Utilized to Value Stock Options (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SupplementalGuarantorCondensedConsolidatingFinancials" roleURI="http://www.hologic.com/role/SupplementalGuarantorCondensedConsolidatingFinancials">
        <link:definition>2118100 - Disclosure - Supplemental Guarantor Condensed Consolidating Financials</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SupplementalGuarantorCondensedConsolidatingFinancialsAdditionalInformationDetail" roleURI="http://www.hologic.com/role/SupplementalGuarantorCondensedConsolidatingFinancialsAdditionalInformationDetail">
        <link:definition>2418402 - Disclosure - Supplemental Guarantor Condensed Consolidating Financials - Additional Information (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SupplementalGuarantorCondensedConsolidatingFinancialsScheduleOfConsolidatingStatementOfCashFlowsDetail" roleURI="http://www.hologic.com/role/SupplementalGuarantorCondensedConsolidatingFinancialsScheduleOfConsolidatingStatementOfCashFlowsDetail">
        <link:definition>2418406 - Disclosure - Supplemental Guarantor Condensed Consolidating Financials - Schedule of Consolidating Statement of Cash Flows (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SupplementalGuarantorCondensedConsolidatingFinancialsScheduleOfSupplementalCondensedConsolidatingBalanceSheetDetail" roleURI="http://www.hologic.com/role/SupplementalGuarantorCondensedConsolidatingFinancialsScheduleOfSupplementalCondensedConsolidatingBalanceSheetDetail">
        <link:definition>2418405 - Disclosure - Supplemental Guarantor Condensed Consolidating Financials - Schedule of Supplemental Condensed Consolidating Balance Sheet (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SupplementalGuarantorCondensedConsolidatingFinancialsScheduleOfSupplementalCondensedConsolidatingStatementOfOperationsDetail" roleURI="http://www.hologic.com/role/SupplementalGuarantorCondensedConsolidatingFinancialsScheduleOfSupplementalCondensedConsolidatingStatementOfOperationsDetail">
        <link:definition>2418403 - Disclosure - Supplemental Guarantor Condensed Consolidating Financials - Schedule of Supplemental Condensed Consolidating Statement of Operations (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SupplementalGuarantorCondensedConsolidatingFinancialsScheduleOfSupplementalCondensedConsolidatingStatementsOfComprehensiveLossIncomeDetail" roleURI="http://www.hologic.com/role/SupplementalGuarantorCondensedConsolidatingFinancialsScheduleOfSupplementalCondensedConsolidatingStatementsOfComprehensiveLossIncomeDetail">
        <link:definition>2418404 - Disclosure - Supplemental Guarantor Condensed Consolidating Financials - Schedule of Supplemental Condensed Consolidating Statements of Comprehensive (Loss) Income (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SupplementalGuarantorCondensedConsolidatingFinancialsTables" roleURI="http://www.hologic.com/role/SupplementalGuarantorCondensedConsolidatingFinancialsTables">
        <link:definition>2318301 - Disclosure - Supplemental Guarantor Condensed Consolidating Financials (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
    </xsd:appinfo>
  </xsd:annotation>
  <xsd:element abstract="true" id="holx_AllOtherCountriesMember" name="AllOtherCountriesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="holx_AmortizationOfDeferredFinancingCosts" name="AmortizationOfDeferredFinancingCosts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="holx_AmountAssessedInDamages" name="AmountAssessedInDamages" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="holx_Amountbywhichtheifconvertedvalueexceedstheprincipalamount" name="Amountbywhichtheifconvertedvalueexceedstheprincipalamount" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="holx_AvailableForSaleSecuritiesGrossUnrealizedGainOne" name="AvailableForSaleSecuritiesGrossUnrealizedGainOne" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="holx_AvailableForSaleSecuritiesGrossUnrealizedLossesTwo" name="AvailableForSaleSecuritiesGrossUnrealizedLossesTwo" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="holx_BasePrincipalAmountForAccretionValue" name="BasePrincipalAmountForAccretionValue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="holx_BasisPointReduction" name="BasisPointReduction" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_BreastHealthMember" name="BreastHealthMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_BusinessLicensesMember" name="BusinessLicensesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="holx_CashSeverancePayments" name="CashSeverancePayments" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_ConsolidationOfDiagnosticsOperationsMember" name="ConsolidationOfDiagnosticsOperationsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_ConvertibleNotesMember" name="ConvertibleNotesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="holx_CostOfGoodsSoldImpairmentOfIntangibleAssets" name="CostOfGoodsSoldImpairmentOfIntangibleAssets" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_CostOfRevenueMember" name="CostOfRevenueMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_CreditAgreementMember" name="CreditAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_CustomerRelationshipsContractsMember" name="CustomerRelationshipsContractsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="holx_DebtInstrumentPrepaidPrincipalAmount" name="DebtInstrumentPrepaidPrincipalAmount" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_DeferredCompensationLiabilitiesMember" name="DeferredCompensationLiabilitiesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="holx_DetailsOfCertainBalanceSheetAccountsTextBlock" name="DetailsOfCertainBalanceSheetAccountsTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_DevelopedTechnologyMember" name="DevelopedTechnologyMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_DiagnosticsMember" name="DiagnosticsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="holx_DirectThirdPartyCostsInterestExpense" name="DirectThirdPartyCostsInterestExpense" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="holx_DivestitureChargesNet" name="DivestitureChargesNet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_DocumentAndEntityInformationAbstract" name="DocumentAndEntityInformationAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_EarningsPerShareLineItems" name="EarningsPerShareLineItems" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_EarningsPerShareTable" name="EarningsPerShareTable" nillable="true" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="holx_EquipmentUnderCustomerUsageAgreements" name="EquipmentUnderCustomerUsageAgreements" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="holx_EquityInEarningsLossOfSubsidiaries" name="EquityInEarningsLossOfSubsidiaries" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="holx_EquitySecurityOtherThanTemporaryImpairmentCharge" name="EquitySecurityOtherThanTemporaryImpairmentCharge" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_EstimatedFairValueOfFinancialInstrumentsLineItems" name="EstimatedFairValueOfFinancialInstrumentsLineItems" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_EstimatedFairValueOfFinancialInstrumentsTable" name="EstimatedFairValueOfFinancialInstrumentsTable" nillable="true" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="holx_ExceedsPercentageOfConversionPriceOfCommonStock" name="ExceedsPercentageOfConversionPriceOfCommonStock" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="holx_FacilityClosureCosts" name="FacilityClosureCosts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_Fiscal2015ChargesMember" name="Fiscal2015ChargesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_GynSurgicalMember" name="GynSurgicalMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="holx_IPRDAssetreclassifiedtoDevelopedTechnology" name="IPRDAssetreclassifiedtoDevelopedTechnology" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="holx_IncrementalCommonSharesAttributableToTheConversionOfDebtSecurities" name="IncrementalCommonSharesAttributableToTheConversionOfDebtSecurities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration" />
  <xsd:element id="holx_IntercompanyNotesPayables" name="IntercompanyNotesPayables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="holx_IntercompanyNotesReceivable" name="IntercompanyNotesReceivable" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="holx_IntercompanyPayables" name="IntercompanyPayables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="holx_IntercompanyReceivables" name="IntercompanyReceivables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="holx_InterestPaymentDuration" name="InterestPaymentDuration" nillable="true" substitutionGroup="xbrli:item" type="us-types:durationStringItemType" xbrli:periodType="duration" />
  <xsd:element id="holx_InterestRateBalanceSheet" name="InterestRateBalanceSheet" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="holx_InterestRateCapAgreementsAggregatePremiumPayable" name="InterestRateCapAgreementsAggregatePremiumPayable" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="holx_InvestmentInSubsidiaries" name="InvestmentInSubsidiaries" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="holx_LongTermDebtObligationsWithoutConvertibleNotes" name="LongTermDebtObligationsWithoutConvertibleNotes" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="holx_LossContingencyDamagesSoughtRelatedToAdditionalContingentConsiderationUnderMergerAndAcquisitionAgreement" name="LossContingencyDamagesSoughtRelatedToAdditionalContingentConsiderationUnderMergerAndAcquisitionAgreement" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="holx_ManufacturingEquipmentAndSoftware" name="ManufacturingEquipmentAndSoftware" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="holx_MaximumTargetNumberOfSharesIssuedBasedOnStockPerformanceInPercent" name="MaximumTargetNumberOfSharesIssuedBasedOnStockPerformanceInPercent" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="holx_MinimumTargetNumberOfSharesIssuedOnStockPerformanceInPercent" name="MinimumTargetNumberOfSharesIssuedOnStockPerformanceInPercent" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_MolecularDiagnosticsOperationsMember" name="MolecularDiagnosticsOperationsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_MutualFundsMember" name="MutualFundsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="holx_NumberOfCustomersAccountingForMoreThanTenPercentOfAccountsReceivable" name="NumberOfCustomersAccountingForMoreThanTenPercentOfAccountsReceivable" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant" />
  <xsd:element id="holx_NumberOfCustomersAccountingForMoreThanTenPercentOfRevenue" name="NumberOfCustomersAccountingForMoreThanTenPercentOfRevenue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element id="holx_NumberofDebtInstruments" name="NumberofDebtInstruments" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element id="holx_NumberofFinancialRatioCovenants" name="NumberofFinancialRatioCovenants" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element id="holx_Numberofcountrieswithgreaterthan10ofconsolidatedrevenue" name="Numberofcountrieswithgreaterthan10ofconsolidatedrevenue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="holx_OtherOperatingCostReductionsMember" name="OtherOperatingCostReductionsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="holx_OtherRestructuringPayments" name="OtherRestructuringPayments" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="holx_PaymentForTaxWithholdingRelatedToVestedAndReleasedRestrictedStockUnits" name="PaymentForTaxWithholdingRelatedToVestedAndReleasedRestrictedStockUnits" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="holx_PaymentOfDeferredAcquisitionConsideration" name="PaymentOfDeferredAcquisitionConsideration" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="holx_PaymentsToManufactureEquipmentUnderCustomerUsageAgreements" name="PaymentsToManufactureEquipmentUnderCustomerUsageAgreements" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="holx_PercentageOfRevenues" name="PercentageOfRevenues" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="holx_PrincipalAmountOfBorrowings" name="PrincipalAmountOfBorrowings" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="holx_ProceedsFromSaleOfBusiness" name="ProceedsFromSaleOfBusiness" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="holx_ReductionOfWorkforceExpenses" name="ReductionOfWorkforceExpenses" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_ResearchAndDevelopmentMember" name="ResearchAndDevelopmentMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_RestructuringActionTwoThousandFifteenMember" name="RestructuringActionTwoThousandFifteenMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_RestructuringActionTwoThousandFourteenMember" name="RestructuringActionTwoThousandFourteenMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="holx_RestructuringChargesUnderExitOrDisposalPlan" name="RestructuringChargesUnderExitOrDisposalPlan" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_ScheduleOfGeographicalSegmentsLineItems" name="ScheduleOfGeographicalSegmentsLineItems" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_ScheduleOfGeographicalSegmentsTable" name="ScheduleOfGeographicalSegmentsTable" nillable="true" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="holx_ScheduleOfInterestExpenseUnderConvertibleNotesTableTextBlock" name="ScheduleOfInterestExpenseUnderConvertibleNotesTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_ScheduleOfMarketableSecuritiesLineItems" name="ScheduleOfMarketableSecuritiesLineItems" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_ScheduleOfMarketableSecuritiesTable" name="ScheduleOfMarketableSecuritiesTable" nillable="true" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="holx_ScheduleOfShareBasedCompensationExpenseTableTextBlock" name="ScheduleOfShareBasedCompensationExpenseTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_SegmentReportingDisclosureLineItems" name="SegmentReportingDisclosureLineItems" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_SegmentReportingDisclosureTable" name="SegmentReportingDisclosureTable" nillable="true" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="holx_Severanceandbenefitsandfacilityclosurecosts" name="Severanceandbenefitsandfacilityclosurecosts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="holx_ShareBasedCompensationExpenseIncludedOtherRestructuringCosts" name="ShareBasedCompensationExpenseIncludedOtherRestructuringCosts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="holx_SharedBasedCompensationArrangementRestrictedStockVestingPeriod" name="SharedBasedCompensationArrangementRestrictedStockVestingPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_SkeletalHealthMember" name="SkeletalHealthMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_TermLoanAMember" name="TermLoanAMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_TermLoanBMember" name="TermLoanBMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_TwoThousandAndTenNotesMember" name="TwoThousandAndTenNotesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_TwoThousandAndThirteenNotesMember" name="TwoThousandAndThirteenNotesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_TwoThousandAndTwelveNotesMember" name="TwoThousandAndTwelveNotesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_TwoThousandFifteenMember" name="TwoThousandFifteenMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_TwoThousandTenOriginalNotesMember" name="TwoThousandTenOriginalNotesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_YearTwoThousandFourteenMember" name="YearTwoThousandFourteenMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
</xsd:schema>
