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  <xsd:element id="holx_PaymentsToManufactureEquipmentUnderCustomerUsageAgreements" name="PaymentsToManufactureEquipmentUnderCustomerUsageAgreements" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_PensioninAccumulatedOtherComprehensiveIncomeMember" name="PensioninAccumulatedOtherComprehensiveIncomeMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="holx_PercentageOfRevenues" name="PercentageOfRevenues" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="holx_PrincipalAmountOfBorrowings" name="PrincipalAmountOfBorrowings" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="holx_ProductLineLineItems" name="ProductLineLineItems" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_ProductLineTable" name="ProductLineTable" nillable="true" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_ProductWarrantiesAbstract" name="ProductWarrantiesAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="holx_ReductionOfWorkforceExpenses" name="ReductionOfWorkforceExpenses" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_RestructuringActionTwoThousandFifteenMember" name="RestructuringActionTwoThousandFifteenMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_RestructuringActionTwoThousandFourteenMember" name="RestructuringActionTwoThousandFourteenMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="holx_RestructuringChargesUnderExitOrDisposalPlan" name="RestructuringChargesUnderExitOrDisposalPlan" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_SanDiegoMember" name="SanDiegoMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_ScheduleOfGeographicalSegmentsLineItems" name="ScheduleOfGeographicalSegmentsLineItems" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_ScheduleOfGeographicalSegmentsTable" name="ScheduleOfGeographicalSegmentsTable" nillable="true" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="holx_ScheduleOfInterestExpenseUnderConvertibleNotesTableTextBlock" name="ScheduleOfInterestExpenseUnderConvertibleNotesTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_ScheduleOfMarketableSecuritiesLineItems" name="ScheduleOfMarketableSecuritiesLineItems" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="holx_ScheduleOfShareBasedCompensationExpenseTableTextBlock" name="ScheduleOfShareBasedCompensationExpenseTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_SegmentReportingDisclosureLineItems" name="SegmentReportingDisclosureLineItems" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="holx_SharedBasedCompensationArrangementRestrictedStockVestingPeriod" name="SharedBasedCompensationArrangementRestrictedStockVestingPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_SkeletalHealthMember" name="SkeletalHealthMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_TermLoanMember" name="TermLoanMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_TwoThousandAndThirteenNotesMember" name="TwoThousandAndThirteenNotesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_TwoThousandAndTwelveNotesMember" name="TwoThousandAndTwelveNotesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_TwoThousandSeventeenMember" name="TwoThousandSeventeenMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_TwoThousandSixteenMember" name="TwoThousandSixteenMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="holx_YearTwoThousandSixteenDomain" name="YearTwoThousandSixteenDomain" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
</xsd:schema>
