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Revenue - Revenue by Type (Details) - USD ($) $ in Millions	12 Months Ended
	Sep. 24, 2022	Sep. 25, 2021	Sep. 26, 2020
Disaggregation of Revenue [Line Items]
Revenues	$ 4,862.8	$ 5,632.3	$ 3,776.4
Diagnostics
Disaggregation of Revenue [Line Items]
Revenues	3,018.5	3,695.0	2,102.1
United States
Disaggregation of Revenue [Line Items]
Revenues	3,467.9	3,902.3	2,863.2
United States | Diagnostics
Disaggregation of Revenue [Line Items]
Revenues	2,027.3	2,393.1	1,582.4
International
Disaggregation of Revenue [Line Items]
Revenues	1,394.9	1,730.0	913.2
International | Diagnostics
Disaggregation of Revenue [Line Items]
Revenues	991.2	1,301.9	519.7
Consumables
Disaggregation of Revenue [Line Items]
Revenues	3,603.6	4,198.2	2,561.1
Capital equipment, components and software
Disaggregation of Revenue [Line Items]
Revenues	587.6	769.1	665.9
Service
Disaggregation of Revenue [Line Items]
Revenues	652.4	598.1	516.6
Other
Disaggregation of Revenue [Line Items]
Revenues	19.2	66.9	32.8
Cytology & Perinatal | Diagnostics
Disaggregation of Revenue [Line Items]
Revenues	474.7	473.9	410.1
Cytology & Perinatal | United States | Diagnostics
Disaggregation of Revenue [Line Items]
Revenues	300.4	304.6	266.3
Cytology & Perinatal | International | Diagnostics
Disaggregation of Revenue [Line Items]
Revenues	174.3	169.3	143.8
Molecular Diagnostics | Diagnostics
Disaggregation of Revenue [Line Items]
Revenues	2,511.4	3,171.5	1,648.4
Molecular Diagnostics | United States | Diagnostics
Disaggregation of Revenue [Line Items]
Revenues	1,694.5	2,038.9	1,272.5
Molecular Diagnostics | International | Diagnostics
Disaggregation of Revenue [Line Items]
Revenues	816.9	1,132.6	375.9
Blood screening [Member] | Diagnostics
Disaggregation of Revenue [Line Items]
Revenues	32.4	49.6	43.6
Blood screening [Member] | United States | Diagnostics
Disaggregation of Revenue [Line Items]
Revenues	32.4	49.6	43.6
Blood screening [Member] | International | Diagnostics
Disaggregation of Revenue [Line Items]
Revenues	$ 0.0	$ 0.0	$ 0.0

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