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  <xs:element id="holx_DanburyClosureMember" abstract="true" name="DanburyClosureMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="holx_LongTermDebtObligationsWithoutConvertibleNotes" abstract="false" name="LongTermDebtObligationsWithoutConvertibleNotes" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="holx_OtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentNetTaxExcludingAmountsReclassifiedFromAOCI" abstract="false" name="OtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentNetTaxExcludingAmountsReclassifiedFromAOCI" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="holx_BusinessCombinationContingentConsiderationPayments" abstract="false" name="BusinessCombinationContingentConsiderationPayments" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="holx_MarketBasedAwardsMember" abstract="true" name="MarketBasedAwardsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="holx_AmortizationCostofGoodsSold" abstract="false" name="AmortizationCostofGoodsSold" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="holx_AllOtherCountriesMember" abstract="true" name="AllOtherCountriesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="holx_Repaymentsofacquiredlongtermdebt" abstract="false" name="Repaymentsofacquiredlongtermdebt" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="holx_DepartmentOfDefenseFundsReceived" abstract="false" name="DepartmentOfDefenseFundsReceived" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="holx_CustomerRelationshipsContractsMember" abstract="true" name="CustomerRelationshipsContractsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="holx_PercentageOfRevenues" abstract="false" name="PercentageOfRevenues" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="holx_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedDevelopedTechnology" abstract="false" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedDevelopedTechnology" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="holx_ScheduleOfGeographicalSegmentsTable" abstract="true" name="ScheduleOfGeographicalSegmentsTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="holx_ScheduleOfGeographicalSegmentsLineItems" abstract="true" name="ScheduleOfGeographicalSegmentsLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="holx_September222022Member" abstract="true" name="September222022Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="holx_A2028And2029SeniorNotesMember" abstract="true" name="A2028And2029SeniorNotesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="holx_PSUFreeCashFlowMember" abstract="true" name="PSUFreeCashFlowMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="holx_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCustomerRelationships" abstract="false" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCustomerRelationships" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="holx_Purchaseofinsurancecontracts" abstract="false" name="Purchaseofinsurancecontracts" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="holx_RevolverMember" abstract="true" name="RevolverMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="holx_ScheduleOfShareBasedCompensationExpenseTableTextBlock" abstract="false" name="ScheduleOfShareBasedCompensationExpenseTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="holx_PrepaidIncomeTaxesCurrent" abstract="false" name="PrepaidIncomeTaxesCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="holx_A2029SeniorNotesMember" abstract="true" name="A2029SeniorNotesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="holx_A2021TermLoanMember" abstract="true" name="A2021TermLoanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="holx_A2021CreditAgreementMember" abstract="true" name="A2021CreditAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="holx_DiagnosticsMember" abstract="true" name="DiagnosticsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
</xs:schema>
