<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2022 Workiva-->
<!--r:879d6ea0-64c1-4dd6-9aec-e08ca1e8d849,g:f89c1af5-dc01-41de-a344-97508c66ee24-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://www.cfindustries.com/role/CONSOLIDATEDSTATEMENTSOFEQUITY" xlink:type="simple" xlink:href="cf-20220930.xsd#CONSOLIDATEDSTATEMENTSOFEQUITY"/>
  <link:definitionLink xlink:role="http://www.cfindustries.com/role/CONSOLIDATEDSTATEMENTSOFEQUITY" xlink:type="extended" id="i4c9e4fd4f8664d1a9cd14fe0a8b059d4_CONSOLIDATEDSTATEMENTSOFEQUITY">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_40902126-bb8e-4d5b-adb2-d0721e344dea" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_7061b4a5-d52a-4f10-bbe5-2a3c1cf5681e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_40902126-bb8e-4d5b-adb2-d0721e344dea" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_7061b4a5-d52a-4f10-bbe5-2a3c1cf5681e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_47368ccd-f992-4a2c-9a83-05f66b976c26" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_7061b4a5-d52a-4f10-bbe5-2a3c1cf5681e" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_47368ccd-f992-4a2c-9a83-05f66b976c26" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_4672d628-2246-4d1b-b7a6-77580056729a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProfitLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_7061b4a5-d52a-4f10-bbe5-2a3c1cf5681e" xlink:to="loc_us-gaap_ProfitLoss_4672d628-2246-4d1b-b7a6-77580056729a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_cbdd0f32-f697-414c-9db6-96d54663001f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_7061b4a5-d52a-4f10-bbe5-2a3c1cf5681e" xlink:to="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_cbdd0f32-f697-414c-9db6-96d54663001f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_fe6e988c-9b1c-4cb8-a1be-f7dda0095f53" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_7061b4a5-d52a-4f10-bbe5-2a3c1cf5681e" xlink:to="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_fe6e988c-9b1c-4cb8-a1be-f7dda0095f53" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_e12cba75-a582-475c-9a2d-d3a45c2d8498" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_7061b4a5-d52a-4f10-bbe5-2a3c1cf5681e" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_e12cba75-a582-475c-9a2d-d3a45c2d8498" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_89ea6176-eac7-4606-b2d6-7bd88ed90903" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TreasuryStockValueAcquiredCostMethod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_7061b4a5-d52a-4f10-bbe5-2a3c1cf5681e" xlink:to="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_89ea6176-eac7-4606-b2d6-7bd88ed90903" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockRetiredCostMethodAmount_bf75d559-8bbb-4c5d-8f23-e6d6653e2fa9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TreasuryStockRetiredCostMethodAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_7061b4a5-d52a-4f10-bbe5-2a3c1cf5681e" xlink:to="loc_us-gaap_TreasuryStockRetiredCostMethodAmount_bf75d559-8bbb-4c5d-8f23-e6d6653e2fa9" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_AcquisitionOfTreasuryStockUnderEmployeeStockPlans_a5458598-2d4b-406e-8b54-0ce38e3728cd" xlink:href="cf-20220930.xsd#cf_AcquisitionOfTreasuryStockUnderEmployeeStockPlans"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_7061b4a5-d52a-4f10-bbe5-2a3c1cf5681e" xlink:to="loc_cf_AcquisitionOfTreasuryStockUnderEmployeeStockPlans_a5458598-2d4b-406e-8b54-0ce38e3728cd" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_c2dd2a4d-afd8-4a6a-a14e-e155821248b6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_7061b4a5-d52a-4f10-bbe5-2a3c1cf5681e" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_c2dd2a4d-afd8-4a6a-a14e-e155821248b6" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_caad49b6-17cf-4e72-a839-040850a1d875" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_7061b4a5-d52a-4f10-bbe5-2a3c1cf5681e" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_caad49b6-17cf-4e72-a839-040850a1d875" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockDividendsPerShareCashPaid_e03fa288-47f8-4751-94e8-19b74a94860f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockDividendsPerShareCashPaid"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_7061b4a5-d52a-4f10-bbe5-2a3c1cf5681e" xlink:to="loc_us-gaap_CommonStockDividendsPerShareCashPaid_e03fa288-47f8-4751-94e8-19b74a94860f" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsCommonStockCash_75c0ff86-3b63-4eac-aca4-daaad4c8f874" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DividendsCommonStockCash"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_7061b4a5-d52a-4f10-bbe5-2a3c1cf5681e" xlink:to="loc_us-gaap_DividendsCommonStockCash_75c0ff86-3b63-4eac-aca4-daaad4c8f874" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterestDecreaseFromDistributionsToNoncontrollingInterestHolders_c3a2dff0-76a1-45ba-a5f5-148a412ec2c6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MinorityInterestDecreaseFromDistributionsToNoncontrollingInterestHolders"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_7061b4a5-d52a-4f10-bbe5-2a3c1cf5681e" xlink:to="loc_us-gaap_MinorityInterestDecreaseFromDistributionsToNoncontrollingInterestHolders_c3a2dff0-76a1-45ba-a5f5-148a412ec2c6" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_1cf44eaf-a2b4-4107-86c2-edbdf1073939" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_f4fdfbf1-bb8c-41b6-a310-65da432f1921" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_40902126-bb8e-4d5b-adb2-d0721e344dea" xlink:to="loc_us-gaap_StatementTable_f4fdfbf1-bb8c-41b6-a310-65da432f1921" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_795bc3de-3269-44fa-b5f5-4ed35bf451d1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_f4fdfbf1-bb8c-41b6-a310-65da432f1921" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_795bc3de-3269-44fa-b5f5-4ed35bf451d1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_795bc3de-3269-44fa-b5f5-4ed35bf451d1_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_795bc3de-3269-44fa-b5f5-4ed35bf451d1" xlink:to="loc_us-gaap_EquityComponentDomain_795bc3de-3269-44fa-b5f5-4ed35bf451d1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_532b2640-d3ef-49c6-bb2d-cc5d99b501fa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_795bc3de-3269-44fa-b5f5-4ed35bf451d1" xlink:to="loc_us-gaap_EquityComponentDomain_532b2640-d3ef-49c6-bb2d-cc5d99b501fa" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_0630aef0-fbac-4706-96d5-2cc3e647c033" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_532b2640-d3ef-49c6-bb2d-cc5d99b501fa" xlink:to="loc_us-gaap_CommonStockMember_0630aef0-fbac-4706-96d5-2cc3e647c033" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockMember_8b27c8f1-ebb6-467d-8ba1-d6faf3fa7295" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TreasuryStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_532b2640-d3ef-49c6-bb2d-cc5d99b501fa" xlink:to="loc_us-gaap_TreasuryStockMember_8b27c8f1-ebb6-467d-8ba1-d6faf3fa7295" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_505566f6-f061-401a-9674-1473c882386b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_532b2640-d3ef-49c6-bb2d-cc5d99b501fa" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_505566f6-f061-401a-9674-1473c882386b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_f5a62555-d36e-4006-bed9-6eb58a424068" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_532b2640-d3ef-49c6-bb2d-cc5d99b501fa" xlink:to="loc_us-gaap_RetainedEarningsMember_f5a62555-d36e-4006-bed9-6eb58a424068" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_0057c96e-e763-4f6a-9230-634bb6674532" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_532b2640-d3ef-49c6-bb2d-cc5d99b501fa" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_0057c96e-e763-4f6a-9230-634bb6674532" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ParentMember_d773052a-6ed5-461f-9913-1e9cd15177b0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ParentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_532b2640-d3ef-49c6-bb2d-cc5d99b501fa" xlink:to="loc_us-gaap_ParentMember_d773052a-6ed5-461f-9913-1e9cd15177b0" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoncontrollingInterestMember_31ac64c8-c1df-44c4-93c6-85d43bc69ff6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_532b2640-d3ef-49c6-bb2d-cc5d99b501fa" xlink:to="loc_us-gaap_NoncontrollingInterestMember_31ac64c8-c1df-44c4-93c6-85d43bc69ff6" xlink:type="arc" order="6"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cfindustries.com/role/RevenueRecognitionRevenuebyProductandbyGeographyDetails" xlink:type="simple" xlink:href="cf-20220930.xsd#RevenueRecognitionRevenuebyProductandbyGeographyDetails"/>
  <link:definitionLink xlink:role="http://www.cfindustries.com/role/RevenueRecognitionRevenuebyProductandbyGeographyDetails" xlink:type="extended" id="if7a41ba1d4444de182802e71c203d19f_RevenueRecognitionRevenuebyProductandbyGeographyDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_df395464-3960-4fac-8f86-83e19c92d91f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisaggregationOfRevenueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_97167f0f-92df-4d35-b4e8-188327fc3bc9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Revenues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_df395464-3960-4fac-8f86-83e19c92d91f" xlink:to="loc_us-gaap_Revenues_97167f0f-92df-4d35-b4e8-188327fc3bc9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_4462cfc1-8a7f-4f25-9867-89fe23c3e67c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisaggregationOfRevenueTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_df395464-3960-4fac-8f86-83e19c92d91f" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_4462cfc1-8a7f-4f25-9867-89fe23c3e67c" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_36994081-b362-4a51-a350-02b94298c5c5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_4462cfc1-8a7f-4f25-9867-89fe23c3e67c" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_36994081-b362-4a51-a350-02b94298c5c5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_36994081-b362-4a51-a350-02b94298c5c5_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_36994081-b362-4a51-a350-02b94298c5c5" xlink:to="loc_us-gaap_SegmentDomain_36994081-b362-4a51-a350-02b94298c5c5_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_4ce5faa3-e1ea-495e-add8-99c277287e19" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_36994081-b362-4a51-a350-02b94298c5c5" xlink:to="loc_us-gaap_SegmentDomain_4ce5faa3-e1ea-495e-add8-99c277287e19" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_AmmoniaMember_daeabf59-39b6-44f7-aad2-e4125cac5b50" xlink:href="cf-20220930.xsd#cf_AmmoniaMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_4ce5faa3-e1ea-495e-add8-99c277287e19" xlink:to="loc_cf_AmmoniaMember_daeabf59-39b6-44f7-aad2-e4125cac5b50" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_UreaMember_dde3ad37-4673-4a9b-a2fd-a7c5463321ec" xlink:href="cf-20220930.xsd#cf_UreaMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_4ce5faa3-e1ea-495e-add8-99c277287e19" xlink:to="loc_cf_UreaMember_dde3ad37-4673-4a9b-a2fd-a7c5463321ec" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_UANMember_4411f397-dbf9-4cdc-840f-3517d7d3cbb0" xlink:href="cf-20220930.xsd#cf_UANMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_4ce5faa3-e1ea-495e-add8-99c277287e19" xlink:to="loc_cf_UANMember_4411f397-dbf9-4cdc-840f-3517d7d3cbb0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_AmmoniumNitrateSegmentMember_339b256d-e1f4-48e2-847a-e9209260b9c9" xlink:href="cf-20220930.xsd#cf_AmmoniumNitrateSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_4ce5faa3-e1ea-495e-add8-99c277287e19" xlink:to="loc_cf_AmmoniumNitrateSegmentMember_339b256d-e1f4-48e2-847a-e9209260b9c9" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllOtherSegmentsMember_16483d10-056a-432f-984d-9e471100c1af" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AllOtherSegmentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_4ce5faa3-e1ea-495e-add8-99c277287e19" xlink:to="loc_us-gaap_AllOtherSegmentsMember_16483d10-056a-432f-984d-9e471100c1af" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_ccb5f6a1-a5c9-468a-989e-6deacc9c143e" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_4462cfc1-8a7f-4f25-9867-89fe23c3e67c" xlink:to="loc_srt_StatementGeographicalAxis_ccb5f6a1-a5c9-468a-989e-6deacc9c143e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_ccb5f6a1-a5c9-468a-989e-6deacc9c143e_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_ccb5f6a1-a5c9-468a-989e-6deacc9c143e" xlink:to="loc_srt_SegmentGeographicalDomain_ccb5f6a1-a5c9-468a-989e-6deacc9c143e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_7c75f80f-ec96-442b-aa50-0cf6893f5770" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_ccb5f6a1-a5c9-468a-989e-6deacc9c143e" xlink:to="loc_srt_SegmentGeographicalDomain_7c75f80f-ec96-442b-aa50-0cf6893f5770" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_NorthAmericaMember_b3637eae-3df1-4985-8fe4-55a684dfcc32" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_NorthAmericaMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_7c75f80f-ec96-442b-aa50-0cf6893f5770" xlink:to="loc_srt_NorthAmericaMember_b3637eae-3df1-4985-8fe4-55a684dfcc32" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_EuropeandOtherMember_b606b855-2468-40da-ae24-ae8b2d481af4" xlink:href="cf-20220930.xsd#cf_EuropeandOtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_7c75f80f-ec96-442b-aa50-0cf6893f5770" xlink:to="loc_cf_EuropeandOtherMember_b606b855-2468-40da-ae24-ae8b2d481af4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnusualOrInfrequentItemAxis_1e7ae2ba-7cee-44b7-9c4c-da9eedc39931" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_UnusualOrInfrequentItemAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_4462cfc1-8a7f-4f25-9867-89fe23c3e67c" xlink:to="loc_us-gaap_UnusualOrInfrequentItemAxis_1e7ae2ba-7cee-44b7-9c4c-da9eedc39931" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnusualOrInfrequentItemDomain_1e7ae2ba-7cee-44b7-9c4c-da9eedc39931_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_UnusualOrInfrequentItemDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_UnusualOrInfrequentItemAxis_1e7ae2ba-7cee-44b7-9c4c-da9eedc39931" xlink:to="loc_us-gaap_UnusualOrInfrequentItemDomain_1e7ae2ba-7cee-44b7-9c4c-da9eedc39931_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnusualOrInfrequentItemDomain_7940d9bd-a43b-451d-94b2-192ce20ccb89" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_UnusualOrInfrequentItemDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_UnusualOrInfrequentItemAxis_1e7ae2ba-7cee-44b7-9c4c-da9eedc39931" xlink:to="loc_us-gaap_UnusualOrInfrequentItemDomain_7940d9bd-a43b-451d-94b2-192ce20ccb89" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_WinterStormUriMember_66cb03c7-8506-441b-81b1-ace950283f3f" xlink:href="cf-20220930.xsd#cf_WinterStormUriMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_UnusualOrInfrequentItemDomain_7940d9bd-a43b-451d-94b2-192ce20ccb89" xlink:to="loc_cf_WinterStormUriMember_66cb03c7-8506-441b-81b1-ace950283f3f" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cfindustries.com/role/RevenueRecognitionPerformanceObligationsDetails" xlink:type="simple" xlink:href="cf-20220930.xsd#RevenueRecognitionPerformanceObligationsDetails"/>
  <link:definitionLink xlink:role="http://www.cfindustries.com/role/RevenueRecognitionPerformanceObligationsDetails" xlink:type="extended" id="ied6c6acbcadf4a76a6e204fb72a86f42_RevenueRecognitionPerformanceObligationsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_18bba755-869c-4bd3-89a4-8e2e9f120641" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_RevenueRemainingPerformanceObligationExpectedTimingofSatisfactionPercent_51d75125-8604-468b-b0c4-63a1fd6927ef" xlink:href="cf-20220930.xsd#cf_RevenueRemainingPerformanceObligationExpectedTimingofSatisfactionPercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_18bba755-869c-4bd3-89a4-8e2e9f120641" xlink:to="loc_cf_RevenueRemainingPerformanceObligationExpectedTimingofSatisfactionPercent_51d75125-8604-468b-b0c4-63a1fd6927ef" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable_62029bd6-61da-4053-9547-3fd436da65de" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_18bba755-869c-4bd3-89a4-8e2e9f120641" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable_62029bd6-61da-4053-9547-3fd436da65de" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionStartDateAxis_1190df1b-233d-4e17-8547-e3908c462e2a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionStartDateAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable_62029bd6-61da-4053-9547-3fd436da65de" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionStartDateAxis_1190df1b-233d-4e17-8547-e3908c462e2a" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cfindustries.com/role/RevenueRecognitionPerformanceObligationsDetails_1" xlink:type="simple" xlink:href="cf-20220930.xsd#RevenueRecognitionPerformanceObligationsDetails_1"/>
  <link:definitionLink xlink:role="http://www.cfindustries.com/role/RevenueRecognitionPerformanceObligationsDetails_1" xlink:type="extended" id="i73726c6bf6554b7fb187b55cd29488e6_RevenueRecognitionPerformanceObligationsDetails_1">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_18bba755-869c-4bd3-89a4-8e2e9f120641" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_RevenueRemainingPerformanceObligationExpectedTimingofSatisfactionPercent_51d75125-8604-468b-b0c4-63a1fd6927ef" xlink:href="cf-20220930.xsd#cf_RevenueRemainingPerformanceObligationExpectedTimingofSatisfactionPercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_18bba755-869c-4bd3-89a4-8e2e9f120641" xlink:to="loc_cf_RevenueRemainingPerformanceObligationExpectedTimingofSatisfactionPercent_51d75125-8604-468b-b0c4-63a1fd6927ef" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable_62029bd6-61da-4053-9547-3fd436da65de" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_18bba755-869c-4bd3-89a4-8e2e9f120641" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable_62029bd6-61da-4053-9547-3fd436da65de" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cfindustries.com/role/UnitedKingdomOperationsProposedRestructuringandImpairmentChargesDetails" xlink:type="simple" xlink:href="cf-20220930.xsd#UnitedKingdomOperationsProposedRestructuringandImpairmentChargesDetails"/>
  <link:definitionLink xlink:role="http://www.cfindustries.com/role/UnitedKingdomOperationsProposedRestructuringandImpairmentChargesDetails" xlink:type="extended" id="ia792321f7fe84241aac93775967a0767_UnitedKingdomOperationsProposedRestructuringandImpairmentChargesDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveLineItems_d7584797-d40e-45e2-bdde-d95a08f99da7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestructuringCostAndReserveLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillImpairmentLoss_3f2579ec-9c4c-4ab8-93e9-0006492c7d20" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GoodwillImpairmentLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_d7584797-d40e-45e2-bdde-d95a08f99da7" xlink:to="loc_us-gaap_GoodwillImpairmentLoss_3f2579ec-9c4c-4ab8-93e9-0006492c7d20" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsFinitelived_83449a34-6016-4e9a-b197-890604357129" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ImpairmentOfIntangibleAssetsFinitelived"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_d7584797-d40e-45e2-bdde-d95a08f99da7" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetsFinitelived_83449a34-6016-4e9a-b197-890604357129" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_AdditionalImpairmentOfIntangibleAssetsFiniteLivedDuringPeriod_b7659040-e751-4e71-822a-4457a55ddcae" xlink:href="cf-20220930.xsd#cf_AdditionalImpairmentOfIntangibleAssetsFiniteLivedDuringPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_d7584797-d40e-45e2-bdde-d95a08f99da7" xlink:to="loc_cf_AdditionalImpairmentOfIntangibleAssetsFiniteLivedDuringPeriod_b7659040-e751-4e71-822a-4457a55ddcae" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringSettlementAndImpairmentProvisions_c98f893d-83ae-41e6-aaeb-a4d7da4dc911" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestructuringSettlementAndImpairmentProvisions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_d7584797-d40e-45e2-bdde-d95a08f99da7" xlink:to="loc_us-gaap_RestructuringSettlementAndImpairmentProvisions_c98f893d-83ae-41e6-aaeb-a4d7da4dc911" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetImpairmentCharges_3f6cecc0-23f7-4763-83c5-6051d0120424" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetImpairmentCharges"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_d7584797-d40e-45e2-bdde-d95a08f99da7" xlink:to="loc_us-gaap_AssetImpairmentCharges_3f6cecc0-23f7-4763-83c5-6051d0120424" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfLongLivedAssetsToBeDisposedOf_87e94fd4-c924-418d-b19a-536630189742" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ImpairmentOfLongLivedAssetsToBeDisposedOf"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_d7584797-d40e-45e2-bdde-d95a08f99da7" xlink:to="loc_us-gaap_ImpairmentOfLongLivedAssetsToBeDisposedOf_87e94fd4-c924-418d-b19a-536630189742" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetRetirementObligationPeriodIncreaseDecrease_948f2085-dbb0-4841-b38c-6eadb07b3a31" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetRetirementObligationPeriodIncreaseDecrease"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_d7584797-d40e-45e2-bdde-d95a08f99da7" xlink:to="loc_us-gaap_AssetRetirementObligationPeriodIncreaseDecrease_948f2085-dbb0-4841-b38c-6eadb07b3a31" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsIndefinitelivedExcludingGoodwill_aa9b3dfb-1034-4a89-8969-c3d53838c3c1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ImpairmentOfIntangibleAssetsIndefinitelivedExcludingGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_d7584797-d40e-45e2-bdde-d95a08f99da7" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetsIndefinitelivedExcludingGoodwill_aa9b3dfb-1034-4a89-8969-c3d53838c3c1" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeveranceCosts1_6075478d-8b10-4aa7-9e69-1310cd8dd4e5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SeveranceCosts1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_d7584797-d40e-45e2-bdde-d95a08f99da7" xlink:to="loc_us-gaap_SeveranceCosts1_6075478d-8b10-4aa7-9e69-1310cd8dd4e5" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_c860ea02-54c0-439f-a866-e31730b1c309" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfRestructuringAndRelatedCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_d7584797-d40e-45e2-bdde-d95a08f99da7" xlink:to="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_c860ea02-54c0-439f-a866-e31730b1c309" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanAxis_11a9b9c3-2d36-4676-bf7e-a2fb78171ae9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestructuringPlanAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_c860ea02-54c0-439f-a866-e31730b1c309" xlink:to="loc_us-gaap_RestructuringPlanAxis_11a9b9c3-2d36-4676-bf7e-a2fb78171ae9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_11a9b9c3-2d36-4676-bf7e-a2fb78171ae9_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringPlanAxis_11a9b9c3-2d36-4676-bf7e-a2fb78171ae9" xlink:to="loc_us-gaap_RestructuringPlanDomain_11a9b9c3-2d36-4676-bf7e-a2fb78171ae9_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_2cf28efb-3750-477e-b6fa-f82154958870" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringPlanAxis_11a9b9c3-2d36-4676-bf7e-a2fb78171ae9" xlink:to="loc_us-gaap_RestructuringPlanDomain_2cf28efb-3750-477e-b6fa-f82154958870" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_InceFacilityMember_f4a87ceb-f6d5-4a42-a6f5-74bf62ab14c6" xlink:href="cf-20220930.xsd#cf_InceFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringPlanDomain_2cf28efb-3750-477e-b6fa-f82154958870" xlink:to="loc_cf_InceFacilityMember_f4a87ceb-f6d5-4a42-a6f5-74bf62ab14c6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_e93d8270-6d95-40b0-b717-38843367d560" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_c860ea02-54c0-439f-a866-e31730b1c309" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_e93d8270-6d95-40b0-b717-38843367d560" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_e93d8270-6d95-40b0-b717-38843367d560_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_e93d8270-6d95-40b0-b717-38843367d560" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_e93d8270-6d95-40b0-b717-38843367d560_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_bf20f98b-fccd-48a0-ba99-e8eae4966202" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_e93d8270-6d95-40b0-b717-38843367d560" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_bf20f98b-fccd-48a0-ba99-e8eae4966202" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TradeNamesMember_81e4a76e-53d4-4095-8d28-8e25981b4b92" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TradeNamesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_bf20f98b-fccd-48a0-ba99-e8eae4966202" xlink:to="loc_us-gaap_TradeNamesMember_81e4a76e-53d4-4095-8d28-8e25981b4b92" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_6d537938-d784-455e-9e86-8bdaf109b2ff" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_c860ea02-54c0-439f-a866-e31730b1c309" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_6d537938-d784-455e-9e86-8bdaf109b2ff" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_6d537938-d784-455e-9e86-8bdaf109b2ff_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_6d537938-d784-455e-9e86-8bdaf109b2ff" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_6d537938-d784-455e-9e86-8bdaf109b2ff_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_4b6e3b08-4a3d-4521-b3b7-55bb3a023501" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_6d537938-d784-455e-9e86-8bdaf109b2ff" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_4b6e3b08-4a3d-4521-b3b7-55bb3a023501" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_RawMaterialAndSparePartsMember_481fbcaa-72ea-4fd4-b868-6775fdcc42d7" xlink:href="cf-20220930.xsd#cf_RawMaterialAndSparePartsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_4b6e3b08-4a3d-4521-b3b7-55bb3a023501" xlink:to="loc_cf_RawMaterialAndSparePartsMember_481fbcaa-72ea-4fd4-b868-6775fdcc42d7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MachineryAndEquipmentMember_fde74665-77dc-42c7-802f-fd686b09ea9b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MachineryAndEquipmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_4b6e3b08-4a3d-4521-b3b7-55bb3a023501" xlink:to="loc_us-gaap_MachineryAndEquipmentMember_fde74665-77dc-42c7-802f-fd686b09ea9b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConstructionInProgressMember_b9a62744-372d-4385-ba03-a2e44e3591ca" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConstructionInProgressMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_4b6e3b08-4a3d-4521-b3b7-55bb3a023501" xlink:to="loc_us-gaap_ConstructionInProgressMember_b9a62744-372d-4385-ba03-a2e44e3591ca" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_da1a1ff1-e45c-48e0-8c20-1c2c385c9b83" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_c860ea02-54c0-439f-a866-e31730b1c309" xlink:to="loc_srt_StatementGeographicalAxis_da1a1ff1-e45c-48e0-8c20-1c2c385c9b83" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_da1a1ff1-e45c-48e0-8c20-1c2c385c9b83_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_da1a1ff1-e45c-48e0-8c20-1c2c385c9b83" xlink:to="loc_srt_SegmentGeographicalDomain_da1a1ff1-e45c-48e0-8c20-1c2c385c9b83_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_2cdc487b-a19d-4e3b-b44d-7db20f3ae74f" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_da1a1ff1-e45c-48e0-8c20-1c2c385c9b83" xlink:to="loc_srt_SegmentGeographicalDomain_2cdc487b-a19d-4e3b-b44d-7db20f3ae74f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_GB_6aab0aaf-2cb7-4a03-b9d5-6a1629dce8ad" xlink:href="https://xbrl.sec.gov/country/2022/country-2022.xsd#country_GB"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_2cdc487b-a19d-4e3b-b44d-7db20f3ae74f" xlink:to="loc_country_GB_6aab0aaf-2cb7-4a03-b9d5-6a1629dce8ad" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cfindustries.com/role/PropertyPlantandEquipmentNetDetails" xlink:type="simple" xlink:href="cf-20220930.xsd#PropertyPlantandEquipmentNetDetails"/>
  <link:definitionLink xlink:role="http://www.cfindustries.com/role/PropertyPlantandEquipmentNetDetails" xlink:type="extended" id="ifbcfb1f8f5634e2c86e3800ab83da109_PropertyPlantandEquipmentNetDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_3081b528-9266-4de5-866a-187e560815b7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_e61271b5-ea0d-4f61-8cdb-2023b0873f97" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_3081b528-9266-4de5-866a-187e560815b7" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_e61271b5-ea0d-4f61-8cdb-2023b0873f97" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_13da55ed-75df-4c8f-91c3-89e2cbbd55dd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_3081b528-9266-4de5-866a-187e560815b7" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_13da55ed-75df-4c8f-91c3-89e2cbbd55dd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_66e87094-4739-4c5c-ac34-1b6a1844a81a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_3081b528-9266-4de5-866a-187e560815b7" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_66e87094-4739-4c5c-ac34-1b6a1844a81a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsFinitelived_5cf20002-a3e7-448b-b439-bafa39ca4cbc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ImpairmentOfIntangibleAssetsFinitelived"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_3081b528-9266-4de5-866a-187e560815b7" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetsFinitelived_5cf20002-a3e7-448b-b439-bafa39ca4cbc" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConstructionInProgressExpendituresIncurredButNotYetPaid_697d2e02-26e9-459e-8384-250459a3d1c2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConstructionInProgressExpendituresIncurredButNotYetPaid"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_3081b528-9266-4de5-866a-187e560815b7" xlink:to="loc_us-gaap_ConstructionInProgressExpendituresIncurredButNotYetPaid_697d2e02-26e9-459e-8384-250459a3d1c2" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSoldDepreciationAndAmortization_b6bf0ea0-085b-459c-ac19-89397fa3c22e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CostOfGoodsAndServicesSoldDepreciationAndAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_3081b528-9266-4de5-866a-187e560815b7" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSoldDepreciationAndAmortization_b6bf0ea0-085b-459c-ac19-89397fa3c22e" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoncurrentAssets_ba38b1fb-b348-40cf-a82d-325f1a98c3ce" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NoncurrentAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_3081b528-9266-4de5-866a-187e560815b7" xlink:to="loc_us-gaap_NoncurrentAssets_ba38b1fb-b348-40cf-a82d-325f1a98c3ce" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_PlantTurnaroundCostsDisclosureAbstract_e57a57ef-a9d6-4f3b-b38f-9f0da82c8128" xlink:href="cf-20220930.xsd#cf_PlantTurnaroundCostsDisclosureAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_3081b528-9266-4de5-866a-187e560815b7" xlink:to="loc_cf_PlantTurnaroundCostsDisclosureAbstract_e57a57ef-a9d6-4f3b-b38f-9f0da82c8128" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_CapitalizedPlantTurnaroundCostsRollForward_62587cb9-592e-4494-bb5f-5eaf1cd1324e" xlink:href="cf-20220930.xsd#cf_CapitalizedPlantTurnaroundCostsRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cf_PlantTurnaroundCostsDisclosureAbstract_e57a57ef-a9d6-4f3b-b38f-9f0da82c8128" xlink:to="loc_cf_CapitalizedPlantTurnaroundCostsRollForward_62587cb9-592e-4494-bb5f-5eaf1cd1324e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_CapitalizedPlantTurnaroundCosts_84c14444-4e95-4e8a-a753-2ddf38e859c4" xlink:href="cf-20220930.xsd#cf_CapitalizedPlantTurnaroundCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cf_CapitalizedPlantTurnaroundCostsRollForward_62587cb9-592e-4494-bb5f-5eaf1cd1324e" xlink:to="loc_cf_CapitalizedPlantTurnaroundCosts_84c14444-4e95-4e8a-a753-2ddf38e859c4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_CapitalizedPlantTurnaroundAdditions_93c4285c-80d6-49b2-97f1-dd4b3f06f65e" xlink:href="cf-20220930.xsd#cf_CapitalizedPlantTurnaroundAdditions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cf_CapitalizedPlantTurnaroundCostsRollForward_62587cb9-592e-4494-bb5f-5eaf1cd1324e" xlink:to="loc_cf_CapitalizedPlantTurnaroundAdditions_93c4285c-80d6-49b2-97f1-dd4b3f06f65e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_CapitalizedPlantTurnaroundDepreciation_f5ff5226-f1c7-43d2-a4b4-5ac4f9296da7" xlink:href="cf-20220930.xsd#cf_CapitalizedPlantTurnaroundDepreciation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cf_CapitalizedPlantTurnaroundCostsRollForward_62587cb9-592e-4494-bb5f-5eaf1cd1324e" xlink:to="loc_cf_CapitalizedPlantTurnaroundDepreciation_f5ff5226-f1c7-43d2-a4b4-5ac4f9296da7" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_CapitalizedPlantTurnaroundImpairment_4a9c1e65-07a3-4402-8c54-aa38adb6757d" xlink:href="cf-20220930.xsd#cf_CapitalizedPlantTurnaroundImpairment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cf_CapitalizedPlantTurnaroundCostsRollForward_62587cb9-592e-4494-bb5f-5eaf1cd1324e" xlink:to="loc_cf_CapitalizedPlantTurnaroundImpairment_4a9c1e65-07a3-4402-8c54-aa38adb6757d" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_CapitalizedPlantTurnaroundCostChangesInExchangeRateEffect_9b546fce-5340-4843-861d-ba0aafb9052e" xlink:href="cf-20220930.xsd#cf_CapitalizedPlantTurnaroundCostChangesInExchangeRateEffect"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cf_CapitalizedPlantTurnaroundCostsRollForward_62587cb9-592e-4494-bb5f-5eaf1cd1324e" xlink:to="loc_cf_CapitalizedPlantTurnaroundCostChangesInExchangeRateEffect_9b546fce-5340-4843-861d-ba0aafb9052e" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_CapitalizedPlantTurnaroundCosts_bef58f56-2b26-4f67-9fce-a0f89f19e5a8" xlink:href="cf-20220930.xsd#cf_CapitalizedPlantTurnaroundCosts"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringSettlementAndImpairmentProvisions_1d6eb321-ceae-4285-b112-523fae26944c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestructuringSettlementAndImpairmentProvisions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_3081b528-9266-4de5-866a-187e560815b7" xlink:to="loc_us-gaap_RestructuringSettlementAndImpairmentProvisions_1d6eb321-ceae-4285-b112-523fae26944c" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfLongLivedAssetsToBeDisposedOf_c3ca4d62-8080-427e-a00c-406221c69f13" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ImpairmentOfLongLivedAssetsToBeDisposedOf"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_3081b528-9266-4de5-866a-187e560815b7" xlink:to="loc_us-gaap_ImpairmentOfLongLivedAssetsToBeDisposedOf_c3ca4d62-8080-427e-a00c-406221c69f13" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_c78329e7-1b8d-4ac0-92a5-c7d7f0629eb0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_3081b528-9266-4de5-866a-187e560815b7" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_c78329e7-1b8d-4ac0-92a5-c7d7f0629eb0" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_4c2db356-7751-49d3-a438-f857196a21ab" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_c78329e7-1b8d-4ac0-92a5-c7d7f0629eb0" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_4c2db356-7751-49d3-a438-f857196a21ab" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_4c2db356-7751-49d3-a438-f857196a21ab_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_4c2db356-7751-49d3-a438-f857196a21ab" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_4c2db356-7751-49d3-a438-f857196a21ab_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_8441699f-3a6d-4261-8d59-9fa5bffc4c91" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_4c2db356-7751-49d3-a438-f857196a21ab" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_8441699f-3a6d-4261-8d59-9fa5bffc4c91" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LandMember_26bf8f1e-7e18-491c-8580-90b49e3bcdda" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LandMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_8441699f-3a6d-4261-8d59-9fa5bffc4c91" xlink:to="loc_us-gaap_LandMember_26bf8f1e-7e18-491c-8580-90b49e3bcdda" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MachineryAndEquipmentMember_9c91ea03-1508-47db-8f1b-8a37b885d795" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MachineryAndEquipmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_8441699f-3a6d-4261-8d59-9fa5bffc4c91" xlink:to="loc_us-gaap_MachineryAndEquipmentMember_9c91ea03-1508-47db-8f1b-8a37b885d795" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BuildingAndBuildingImprovementsMember_6f9766a0-b8ee-432c-9db7-caa6a7a5a4dd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BuildingAndBuildingImprovementsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_8441699f-3a6d-4261-8d59-9fa5bffc4c91" xlink:to="loc_us-gaap_BuildingAndBuildingImprovementsMember_6f9766a0-b8ee-432c-9db7-caa6a7a5a4dd" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConstructionInProgressMember_e731f9c2-4052-4075-8905-9086dd9b2d71" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConstructionInProgressMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_8441699f-3a6d-4261-8d59-9fa5bffc4c91" xlink:to="loc_us-gaap_ConstructionInProgressMember_e731f9c2-4052-4075-8905-9086dd9b2d71" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentMember_76e6dc0b-4cfa-490a-b994-a13359fe3659" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_8441699f-3a6d-4261-8d59-9fa5bffc4c91" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentMember_76e6dc0b-4cfa-490a-b994-a13359fe3659" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_42a56b5b-eea8-426d-9015-eaa1327d3ddc" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_c78329e7-1b8d-4ac0-92a5-c7d7f0629eb0" xlink:to="loc_srt_StatementGeographicalAxis_42a56b5b-eea8-426d-9015-eaa1327d3ddc" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_42a56b5b-eea8-426d-9015-eaa1327d3ddc_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_42a56b5b-eea8-426d-9015-eaa1327d3ddc" xlink:to="loc_srt_SegmentGeographicalDomain_42a56b5b-eea8-426d-9015-eaa1327d3ddc_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_9530648f-4173-4f0c-97b5-5041d3afabd3" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_42a56b5b-eea8-426d-9015-eaa1327d3ddc" xlink:to="loc_srt_SegmentGeographicalDomain_9530648f-4173-4f0c-97b5-5041d3afabd3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_GB_21d28821-a566-4a3c-9a90-bfbc7538ff9c" xlink:href="https://xbrl.sec.gov/country/2022/country-2022.xsd#country_GB"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_9530648f-4173-4f0c-97b5-5041d3afabd3" xlink:to="loc_country_GB_21d28821-a566-4a3c-9a90-bfbc7538ff9c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanAxis_039dfb09-233d-411a-ac55-00658b6ab16f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestructuringPlanAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_c78329e7-1b8d-4ac0-92a5-c7d7f0629eb0" xlink:to="loc_us-gaap_RestructuringPlanAxis_039dfb09-233d-411a-ac55-00658b6ab16f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_039dfb09-233d-411a-ac55-00658b6ab16f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringPlanAxis_039dfb09-233d-411a-ac55-00658b6ab16f" xlink:to="loc_us-gaap_RestructuringPlanDomain_039dfb09-233d-411a-ac55-00658b6ab16f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_350d33b0-a410-4e26-b3a9-b2e9da8329df" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringPlanAxis_039dfb09-233d-411a-ac55-00658b6ab16f" xlink:to="loc_us-gaap_RestructuringPlanDomain_350d33b0-a410-4e26-b3a9-b2e9da8329df" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_InceFacilityMember_2487c50b-99ba-48e0-bc11-2a6db35b067c" xlink:href="cf-20220930.xsd#cf_InceFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringPlanDomain_350d33b0-a410-4e26-b3a9-b2e9da8329df" xlink:to="loc_cf_InceFacilityMember_2487c50b-99ba-48e0-bc11-2a6db35b067c" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cfindustries.com/role/GoodwillandOtherIntangibleAssetsDetails" xlink:type="simple" xlink:href="cf-20220930.xsd#GoodwillandOtherIntangibleAssetsDetails"/>
  <link:definitionLink xlink:role="http://www.cfindustries.com/role/GoodwillandOtherIntangibleAssetsDetails" xlink:type="extended" id="i2ec9473c37b4459c905473d9889e813f_GoodwillandOtherIntangibleAssetsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillLineItems_57df1dea-31a8-4301-8573-cb7a98d29896" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GoodwillLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillRollForward_8b1511f5-8b4d-405b-a98a-fb89d94a9f08" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GoodwillRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillLineItems_57df1dea-31a8-4301-8573-cb7a98d29896" xlink:to="loc_us-gaap_GoodwillRollForward_8b1511f5-8b4d-405b-a98a-fb89d94a9f08" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_868136d7-c6fb-4953-8356-62f70dca7dad" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Goodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillRollForward_8b1511f5-8b4d-405b-a98a-fb89d94a9f08" xlink:to="loc_us-gaap_Goodwill_868136d7-c6fb-4953-8356-62f70dca7dad" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillForeignCurrencyTranslationGainLoss_7139b755-5b97-4ce9-ada1-ba64a017bb5c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GoodwillForeignCurrencyTranslationGainLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillRollForward_8b1511f5-8b4d-405b-a98a-fb89d94a9f08" xlink:to="loc_us-gaap_GoodwillForeignCurrencyTranslationGainLoss_7139b755-5b97-4ce9-ada1-ba64a017bb5c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_4fd9f8df-188d-47ed-b5a4-ada42cfc112a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Goodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillImpairmentLoss_ce27a3a9-e9b1-4692-a5bd-2bf6ba208e81" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GoodwillImpairmentLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillLineItems_57df1dea-31a8-4301-8573-cb7a98d29896" xlink:to="loc_us-gaap_GoodwillImpairmentLoss_ce27a3a9-e9b1-4692-a5bd-2bf6ba208e81" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfGoodwillTable_9d1ade34-952f-4ac3-8754-2aaa98cdeb11" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfGoodwillTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_GoodwillLineItems_57df1dea-31a8-4301-8573-cb7a98d29896" xlink:to="loc_us-gaap_ScheduleOfGoodwillTable_9d1ade34-952f-4ac3-8754-2aaa98cdeb11" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_08b5548b-e5f1-418e-8eb0-a2dd64068bea" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfGoodwillTable_9d1ade34-952f-4ac3-8754-2aaa98cdeb11" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_08b5548b-e5f1-418e-8eb0-a2dd64068bea" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_08b5548b-e5f1-418e-8eb0-a2dd64068bea_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_08b5548b-e5f1-418e-8eb0-a2dd64068bea" xlink:to="loc_us-gaap_SegmentDomain_08b5548b-e5f1-418e-8eb0-a2dd64068bea_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_6e1b15d4-2c56-4427-85da-2323ec19ce51" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_08b5548b-e5f1-418e-8eb0-a2dd64068bea" xlink:to="loc_us-gaap_SegmentDomain_6e1b15d4-2c56-4427-85da-2323ec19ce51" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_AmmoniaMember_06ff2efb-613e-4f88-adcd-23eb950b4da2" xlink:href="cf-20220930.xsd#cf_AmmoniaMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_6e1b15d4-2c56-4427-85da-2323ec19ce51" xlink:to="loc_cf_AmmoniaMember_06ff2efb-613e-4f88-adcd-23eb950b4da2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_UreaMember_f5582e05-0152-480c-ac66-557da38949dc" xlink:href="cf-20220930.xsd#cf_UreaMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_6e1b15d4-2c56-4427-85da-2323ec19ce51" xlink:to="loc_cf_UreaMember_f5582e05-0152-480c-ac66-557da38949dc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_UANMember_d6f9d1b1-1914-4e55-bda8-68244455bc67" xlink:href="cf-20220930.xsd#cf_UANMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_6e1b15d4-2c56-4427-85da-2323ec19ce51" xlink:to="loc_cf_UANMember_d6f9d1b1-1914-4e55-bda8-68244455bc67" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_AmmoniumNitrateSegmentMember_0e52bc29-d83f-40d5-8165-ed3dae869785" xlink:href="cf-20220930.xsd#cf_AmmoniumNitrateSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_6e1b15d4-2c56-4427-85da-2323ec19ce51" xlink:to="loc_cf_AmmoniumNitrateSegmentMember_0e52bc29-d83f-40d5-8165-ed3dae869785" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_OtherProductsMember_a3232b86-9bfa-4737-8a74-054eda159f8e" xlink:href="cf-20220930.xsd#cf_OtherProductsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_6e1b15d4-2c56-4427-85da-2323ec19ce51" xlink:to="loc_cf_OtherProductsMember_a3232b86-9bfa-4737-8a74-054eda159f8e" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cfindustries.com/role/GoodwillandOtherIntangibleAssetsDetails2" xlink:type="simple" xlink:href="cf-20220930.xsd#GoodwillandOtherIntangibleAssetsDetails2"/>
  <link:definitionLink xlink:role="http://www.cfindustries.com/role/GoodwillandOtherIntangibleAssetsDetails2" xlink:type="extended" id="i31331ce6c0434ec7a38707f680af8988_GoodwillandOtherIntangibleAssetsDetails2">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_898b87b9-d3e8-4e03-a3d2-aa6d2c76a779" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_fc2d3894-6ccc-43f9-90f2-aee97b156a32" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_898b87b9-d3e8-4e03-a3d2-aa6d2c76a779" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_fc2d3894-6ccc-43f9-90f2-aee97b156a32" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_bfcb1622-3307-48c5-83cb-f527e5068ae2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_898b87b9-d3e8-4e03-a3d2-aa6d2c76a779" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_bfcb1622-3307-48c5-83cb-f527e5068ae2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_3b76ee30-62cb-4d6a-8520-5772a04d2346" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_898b87b9-d3e8-4e03-a3d2-aa6d2c76a779" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_3b76ee30-62cb-4d6a-8520-5772a04d2346" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_9488fd7f-6dbd-4135-a9cb-ed576b187bf7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetUsefulLife"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_898b87b9-d3e8-4e03-a3d2-aa6d2c76a779" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_9488fd7f-6dbd-4135-a9cb-ed576b187bf7" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_5ebd77ab-26b5-44a1-a1a3-4675298e2960" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_898b87b9-d3e8-4e03-a3d2-aa6d2c76a779" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_5ebd77ab-26b5-44a1-a1a3-4675298e2960" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsFinitelived_466e9cdd-ef73-45b8-9b64-72d578d85ce6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ImpairmentOfIntangibleAssetsFinitelived"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_898b87b9-d3e8-4e03-a3d2-aa6d2c76a779" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetsFinitelived_466e9cdd-ef73-45b8-9b64-72d578d85ce6" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoncurrentAssets_047d68ec-bc57-43e6-b6e6-652245ccc02b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NoncurrentAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_898b87b9-d3e8-4e03-a3d2-aa6d2c76a779" xlink:to="loc_us-gaap_NoncurrentAssets_047d68ec-bc57-43e6-b6e6-652245ccc02b" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsIndefinitelivedExcludingGoodwill_aea173bb-12a0-4080-814f-d683c82873db" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ImpairmentOfIntangibleAssetsIndefinitelivedExcludingGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_898b87b9-d3e8-4e03-a3d2-aa6d2c76a779" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetsIndefinitelivedExcludingGoodwill_aea173bb-12a0-4080-814f-d683c82873db" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_13b9d622-fcf6-4126-83fa-44822ddb2dd8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_898b87b9-d3e8-4e03-a3d2-aa6d2c76a779" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_13b9d622-fcf6-4126-83fa-44822ddb2dd8" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_4226a424-4fb6-4155-bf5c-9b10571609c4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_13b9d622-fcf6-4126-83fa-44822ddb2dd8" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_4226a424-4fb6-4155-bf5c-9b10571609c4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_4226a424-4fb6-4155-bf5c-9b10571609c4_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_4226a424-4fb6-4155-bf5c-9b10571609c4" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_4226a424-4fb6-4155-bf5c-9b10571609c4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_b06b9804-8ac5-420b-b83e-cce9168bd0a3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_4226a424-4fb6-4155-bf5c-9b10571609c4" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_b06b9804-8ac5-420b-b83e-cce9168bd0a3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CustomerRelationshipsMember_24450d23-850a-48a0-a4b0-b9ab2908e8a3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CustomerRelationshipsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_b06b9804-8ac5-420b-b83e-cce9168bd0a3" xlink:to="loc_us-gaap_CustomerRelationshipsMember_24450d23-850a-48a0-a4b0-b9ab2908e8a3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TradeNamesMember_a896a9d5-f7a6-4713-8ad2-b1d2ff6ef3f5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TradeNamesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_b06b9804-8ac5-420b-b83e-cce9168bd0a3" xlink:to="loc_us-gaap_TradeNamesMember_a896a9d5-f7a6-4713-8ad2-b1d2ff6ef3f5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_CustomerRelationshipsAndTradeNamesMember_e6db9e13-069a-4aa6-83e1-20aa74fdafe4" xlink:href="cf-20220930.xsd#cf_CustomerRelationshipsAndTradeNamesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_b06b9804-8ac5-420b-b83e-cce9168bd0a3" xlink:to="loc_cf_CustomerRelationshipsAndTradeNamesMember_e6db9e13-069a-4aa6-83e1-20aa74fdafe4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_923994a8-50b3-4af4-90d2-88cdf473fe63" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_13b9d622-fcf6-4126-83fa-44822ddb2dd8" xlink:to="loc_srt_StatementGeographicalAxis_923994a8-50b3-4af4-90d2-88cdf473fe63" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_923994a8-50b3-4af4-90d2-88cdf473fe63_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_923994a8-50b3-4af4-90d2-88cdf473fe63" xlink:to="loc_srt_SegmentGeographicalDomain_923994a8-50b3-4af4-90d2-88cdf473fe63_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_72b1ca6f-4071-495c-99db-18cf81db1dfe" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_923994a8-50b3-4af4-90d2-88cdf473fe63" xlink:to="loc_srt_SegmentGeographicalDomain_72b1ca6f-4071-495c-99db-18cf81db1dfe" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_GB_cdf3f067-c351-42f1-bcfa-40cc54892f8e" xlink:href="https://xbrl.sec.gov/country/2022/country-2022.xsd#country_GB"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_72b1ca6f-4071-495c-99db-18cf81db1dfe" xlink:to="loc_country_GB_cdf3f067-c351-42f1-bcfa-40cc54892f8e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_5a89a673-03ea-4089-818e-378f0d19ce18" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_13b9d622-fcf6-4126-83fa-44822ddb2dd8" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_5a89a673-03ea-4089-818e-378f0d19ce18" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_5a89a673-03ea-4089-818e-378f0d19ce18_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_5a89a673-03ea-4089-818e-378f0d19ce18" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_5a89a673-03ea-4089-818e-378f0d19ce18_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_3cdcb546-35e0-48e3-992e-b0abbceca585" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_5a89a673-03ea-4089-818e-378f0d19ce18" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_3cdcb546-35e0-48e3-992e-b0abbceca585" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TradeNamesMember_d45a444f-c765-479a-b4f7-c24aa2a878a1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TradeNamesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_3cdcb546-35e0-48e3-992e-b0abbceca585" xlink:to="loc_us-gaap_TradeNamesMember_d45a444f-c765-479a-b4f7-c24aa2a878a1" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cfindustries.com/role/EquityMethodInvestmentNarrativeDetails" xlink:type="simple" xlink:href="cf-20220930.xsd#EquityMethodInvestmentNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.cfindustries.com/role/EquityMethodInvestmentNarrativeDetails" xlink:type="extended" id="ie1094cc26ecd47b98375df2ce4df0ee3_EquityMethodInvestmentNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_f0eb063f-502c-401c-964c-af329569e4da" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfEquityMethodInvestmentsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_fca24da6-2288-46fd-b813-18917d7533fc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityMethodInvestmentOwnershipPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_f0eb063f-502c-401c-964c-af329569e4da" xlink:to="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_fca24da6-2288-46fd-b813-18917d7533fc" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityMethodInvestments_fe8def8b-283c-4bac-abc2-908cc600d5c8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityMethodInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_f0eb063f-502c-401c-964c-af329569e4da" xlink:to="loc_us-gaap_EquityMethodInvestments_fe8def8b-283c-4bac-abc2-908cc600d5c8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityMethodInvestmentDifferenceBetweenCarryingAmountAndUnderlyingEquity_d4b36235-5ec4-4ddc-b7aa-690a7ef307fb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityMethodInvestmentDifferenceBetweenCarryingAmountAndUnderlyingEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_f0eb063f-502c-401c-964c-af329569e4da" xlink:to="loc_us-gaap_EquityMethodInvestmentDifferenceBetweenCarryingAmountAndUnderlyingEquity_d4b36235-5ec4-4ddc-b7aa-690a7ef307fb" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_FiniteLivedTangibleAndIntangibleAssetsRevaluationIncreasedBasisDepreciationPeriod_a11599f1-6283-430c-9473-d2fba6ea57d7" xlink:href="cf-20220930.xsd#cf_FiniteLivedTangibleAndIntangibleAssetsRevaluationIncreasedBasisDepreciationPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_f0eb063f-502c-401c-964c-af329569e4da" xlink:to="loc_cf_FiniteLivedTangibleAndIntangibleAssetsRevaluationIncreasedBasisDepreciationPeriod_a11599f1-6283-430c-9473-d2fba6ea57d7" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_UnrecordedUnconditionalPurchaseObligationPercent_38b8963d-d4c3-4ee4-926b-5708b3d94faf" xlink:href="cf-20220930.xsd#cf_UnrecordedUnconditionalPurchaseObligationPercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_f0eb063f-502c-401c-964c-af329569e4da" xlink:to="loc_cf_UnrecordedUnconditionalPurchaseObligationPercent_38b8963d-d4c3-4ee4-926b-5708b3d94faf" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrecordedUnconditionalPurchaseObligationPurchases_9dd57e09-961e-484e-afd9-fc99d2ce6265" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_UnrecordedUnconditionalPurchaseObligationPurchases"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_f0eb063f-502c-401c-964c-af329569e4da" xlink:to="loc_us-gaap_UnrecordedUnconditionalPurchaseObligationPurchases_9dd57e09-961e-484e-afd9-fc99d2ce6265" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_c83310d8-801d-45de-bb36-673ae94ccdd4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfEquityMethodInvestmentsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_f0eb063f-502c-401c-964c-af329569e4da" xlink:to="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_c83310d8-801d-45de-bb36-673ae94ccdd4" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_bdf39d88-309e-487b-8c4b-99fe6f489001" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_LegalEntityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_c83310d8-801d-45de-bb36-673ae94ccdd4" xlink:to="loc_dei_LegalEntityAxis_bdf39d88-309e-487b-8c4b-99fe6f489001" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_bdf39d88-309e-487b-8c4b-99fe6f489001_default" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_bdf39d88-309e-487b-8c4b-99fe6f489001" xlink:to="loc_dei_EntityDomain_bdf39d88-309e-487b-8c4b-99fe6f489001_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_4d9f3e42-fb88-4776-be3a-120ee247ec80" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_bdf39d88-309e-487b-8c4b-99fe6f489001" xlink:to="loc_dei_EntityDomain_4d9f3e42-fb88-4776-be3a-120ee247ec80" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_PointLisasNitrogenLimitedMember_eb91b12b-7f77-44ca-806b-02a64dc26db7" xlink:href="cf-20220930.xsd#cf_PointLisasNitrogenLimitedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_4d9f3e42-fb88-4776-be3a-120ee247ec80" xlink:to="loc_cf_PointLisasNitrogenLimitedMember_eb91b12b-7f77-44ca-806b-02a64dc26db7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_d7de2a93-651c-4910-b46a-e8f4185b84be" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_c83310d8-801d-45de-bb36-673ae94ccdd4" xlink:to="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_d7de2a93-651c-4910-b46a-e8f4185b84be" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_d7de2a93-651c-4910-b46a-e8f4185b84be_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_EquityMethodInvesteeNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_d7de2a93-651c-4910-b46a-e8f4185b84be" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_d7de2a93-651c-4910-b46a-e8f4185b84be_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_e2f10795-1c50-48d7-813b-858cef9124a2" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_EquityMethodInvesteeNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_d7de2a93-651c-4910-b46a-e8f4185b84be" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_e2f10795-1c50-48d7-813b-858cef9124a2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_PointLisasNitrogenLimitedMember_b48348c2-4023-4e51-92ca-fc610eec2fbd" xlink:href="cf-20220930.xsd#cf_PointLisasNitrogenLimitedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_e2f10795-1c50-48d7-813b-858cef9124a2" xlink:to="loc_cf_PointLisasNitrogenLimitedMember_b48348c2-4023-4e51-92ca-fc610eec2fbd" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeAxis_fff5489e-8742-491e-9e1c-0d4c2d7fc471" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_c83310d8-801d-45de-bb36-673ae94ccdd4" xlink:to="loc_us-gaap_InvestmentTypeAxis_fff5489e-8742-491e-9e1c-0d4c2d7fc471" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_fff5489e-8742-491e-9e1c-0d4c2d7fc471_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentTypeCategorizationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_InvestmentTypeAxis_fff5489e-8742-491e-9e1c-0d4c2d7fc471" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_fff5489e-8742-491e-9e1c-0d4c2d7fc471_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_882c5792-5cd6-4fd2-8767-fee43367f28b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentTypeCategorizationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_InvestmentTypeAxis_fff5489e-8742-491e-9e1c-0d4c2d7fc471" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_882c5792-5cd6-4fd2-8767-fee43367f28b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_OperatingEquityMethodInvestmentMember_add6d5df-e8c9-41d3-be78-749027082828" xlink:href="cf-20220930.xsd#cf_OperatingEquityMethodInvestmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_882c5792-5cd6-4fd2-8767-fee43367f28b" xlink:to="loc_cf_OperatingEquityMethodInvestmentMember_add6d5df-e8c9-41d3-be78-749027082828" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_07cbac71-8fdc-4b41-8afc-b6c7ce82b750" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_c83310d8-801d-45de-bb36-673ae94ccdd4" xlink:to="loc_srt_RangeAxis_07cbac71-8fdc-4b41-8afc-b6c7ce82b750" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_07cbac71-8fdc-4b41-8afc-b6c7ce82b750_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_07cbac71-8fdc-4b41-8afc-b6c7ce82b750" xlink:to="loc_srt_RangeMember_07cbac71-8fdc-4b41-8afc-b6c7ce82b750_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_6384c095-c195-4fa8-ac2e-503fd24a2966" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_07cbac71-8fdc-4b41-8afc-b6c7ce82b750" xlink:to="loc_srt_RangeMember_6384c095-c195-4fa8-ac2e-503fd24a2966" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_eb6d9c30-9a8d-40ff-8124-2fb9dc0fdb83" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_6384c095-c195-4fa8-ac2e-503fd24a2966" xlink:to="loc_srt_MaximumMember_eb6d9c30-9a8d-40ff-8124-2fb9dc0fdb83" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_765ca0ff-f627-4de9-8712-8f655e520946" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_c83310d8-801d-45de-bb36-673ae94ccdd4" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_765ca0ff-f627-4de9-8712-8f655e520946" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_765ca0ff-f627-4de9-8712-8f655e520946_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_765ca0ff-f627-4de9-8712-8f655e520946" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_765ca0ff-f627-4de9-8712-8f655e520946_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_73e3e7d8-cb46-4d12-a77a-222bc3de1796" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_765ca0ff-f627-4de9-8712-8f655e520946" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_73e3e7d8-cb46-4d12-a77a-222bc3de1796" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentMember_f0008cdc-399c-4402-978f-bfff0919fb7f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_73e3e7d8-cb46-4d12-a77a-222bc3de1796" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentMember_f0008cdc-399c-4402-978f-bfff0919fb7f" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cfindustries.com/role/FairValueMeasurementsDetails" xlink:type="simple" xlink:href="cf-20220930.xsd#FairValueMeasurementsDetails"/>
  <link:definitionLink xlink:role="http://www.cfindustries.com/role/FairValueMeasurementsDetails" xlink:type="extended" id="i5052161a96cc45f29e09c3fd6bf73fe4_FairValueMeasurementsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfInvestmentsLineItems_edee6446-0d12-4e59-8a5e-df3677c2f8d5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfInvestmentsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Cash_976723f1-675c-4234-a9be-902913503d7f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Cash"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_edee6446-0d12-4e59-8a5e-df3677c2f8d5" xlink:to="loc_us-gaap_Cash_976723f1-675c-4234-a9be-902913503d7f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashEquivalentsAtCarryingValueAbstract_fc43ad6f-ca25-49bb-bc6d-20c6b6caf931" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashEquivalentsAtCarryingValueAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_edee6446-0d12-4e59-8a5e-df3677c2f8d5" xlink:to="loc_us-gaap_CashEquivalentsAtCarryingValueAbstract_fc43ad6f-ca25-49bb-bc6d-20c6b6caf931" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_097e5993-b513-4ab0-8d45-11614247efc9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashEquivalentsAtCarryingValueAbstract_fc43ad6f-ca25-49bb-bc6d-20c6b6caf931" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_097e5993-b513-4ab0-8d45-11614247efc9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_6a36df31-aeec-4ca2-acfb-73a6307d2965" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashEquivalentsAtCarryingValueAbstract_fc43ad6f-ca25-49bb-bc6d-20c6b6caf931" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_6a36df31-aeec-4ca2-acfb-73a6307d2965" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_4539eb1d-244a-4f2d-94c4-b68c21107ed3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashEquivalentsAtCarryingValueAbstract_fc43ad6f-ca25-49bb-bc6d-20c6b6caf931" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_4539eb1d-244a-4f2d-94c4-b68c21107ed3" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_c78a87ea-e9f0-4f41-b401-f3fe0277c152" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashEquivalentsAtCarryingValueAbstract_fc43ad6f-ca25-49bb-bc6d-20c6b6caf931" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_c78a87ea-e9f0-4f41-b401-f3fe0277c152" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfInvestmentsTable_68873805-9d7a-4f24-adf1-1c7c0f4668a0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfInvestmentsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_edee6446-0d12-4e59-8a5e-df3677c2f8d5" xlink:to="loc_us-gaap_ScheduleOfInvestmentsTable_68873805-9d7a-4f24-adf1-1c7c0f4668a0" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_528feefd-8089-4448-bafb-75249f8b561d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfInvestmentsTable_68873805-9d7a-4f24-adf1-1c7c0f4668a0" xlink:to="loc_us-gaap_FinancialInstrumentAxis_528feefd-8089-4448-bafb-75249f8b561d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_528feefd-8089-4448-bafb-75249f8b561d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FinancialInstrumentAxis_528feefd-8089-4448-bafb-75249f8b561d" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_528feefd-8089-4448-bafb-75249f8b561d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_7469c8a8-272d-41a5-a0e7-fe7f86a60d99" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FinancialInstrumentAxis_528feefd-8089-4448-bafb-75249f8b561d" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_7469c8a8-272d-41a5-a0e7-fe7f86a60d99" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentDebtSecuritiesMember_37eeffe9-4853-4399-87f5-759398504d33" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_USGovernmentDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_7469c8a8-272d-41a5-a0e7-fe7f86a60d99" xlink:to="loc_us-gaap_USGovernmentDebtSecuritiesMember_37eeffe9-4853-4399-87f5-759398504d33" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherDebtSecuritiesMember_66cfd7fe-c8f7-4591-a144-728fc7e36dfc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_7469c8a8-272d-41a5-a0e7-fe7f86a60d99" xlink:to="loc_us-gaap_OtherDebtSecuritiesMember_66cfd7fe-c8f7-4591-a144-728fc7e36dfc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TrustForBenefitOfEmployeesMember_664e0a8c-8a69-4080-b214-346b65af8062" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TrustForBenefitOfEmployeesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_7469c8a8-272d-41a5-a0e7-fe7f86a60d99" xlink:to="loc_us-gaap_TrustForBenefitOfEmployeesMember_664e0a8c-8a69-4080-b214-346b65af8062" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_a602cf0b-944d-41b0-9f93-b1b06e203b7d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfInvestmentsTable_68873805-9d7a-4f24-adf1-1c7c0f4668a0" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_a602cf0b-944d-41b0-9f93-b1b06e203b7d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_a602cf0b-944d-41b0-9f93-b1b06e203b7d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_a602cf0b-944d-41b0-9f93-b1b06e203b7d" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_a602cf0b-944d-41b0-9f93-b1b06e203b7d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_2bded446-c8ec-4778-9894-b44c74644381" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_a602cf0b-944d-41b0-9f93-b1b06e203b7d" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_2bded446-c8ec-4778-9894-b44c74644381" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsMember_f90d470d-ebf0-4532-9108-ce295eb3b993" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_2bded446-c8ec-4778-9894-b44c74644381" xlink:to="loc_us-gaap_CashAndCashEquivalentsMember_f90d470d-ebf0-4532-9108-ce295eb3b993" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cfindustries.com/role/FairValueMeasurementsDetails2" xlink:type="simple" xlink:href="cf-20220930.xsd#FairValueMeasurementsDetails2"/>
  <link:definitionLink xlink:role="http://www.cfindustries.com/role/FairValueMeasurementsDetails2" xlink:type="extended" id="iea0896b7fb2943bcb2469294e8efa74b_FairValueMeasurementsDetails2">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_5c229256-67b7-4f97-ad75-587c4cfd2128" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_CashEquivalentsatFairValue_2533b215-96f3-4447-a5b2-0b5300394c59" xlink:href="cf-20220930.xsd#cf_CashEquivalentsatFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_5c229256-67b7-4f97-ad75-587c4cfd2128" xlink:to="loc_cf_CashEquivalentsatFairValue_2533b215-96f3-4447-a5b2-0b5300394c59" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_NonqualifiedEmployeeBenefitTrustsFairValueDisclosure_bdc05e00-1df3-4590-835e-388f1c476712" xlink:href="cf-20220930.xsd#cf_NonqualifiedEmployeeBenefitTrustsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_5c229256-67b7-4f97-ad75-587c4cfd2128" xlink:to="loc_cf_NonqualifiedEmployeeBenefitTrustsFairValueDisclosure_bdc05e00-1df3-4590-835e-388f1c476712" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_2f198c5c-139a-451d-a058-49f89f84442e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_5c229256-67b7-4f97-ad75-587c4cfd2128" xlink:to="loc_us-gaap_DerivativeLiabilities_2f198c5c-139a-451d-a058-49f89f84442e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_baf0e31e-cee9-4ab3-bedf-93ea6dfc33c1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_5c229256-67b7-4f97-ad75-587c4cfd2128" xlink:to="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_baf0e31e-cee9-4ab3-bedf-93ea6dfc33c1" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtFairValue_4fec6639-2f09-4fb3-929f-57ea62cbe0b4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebtFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_5c229256-67b7-4f97-ad75-587c4cfd2128" xlink:to="loc_us-gaap_LongTermDebtFairValue_4fec6639-2f09-4fb3-929f-57ea62cbe0b4" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssets_5cb5ea4b-31e8-4f96-96a4-7d2d7d3ea11a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_5c229256-67b7-4f97-ad75-587c4cfd2128" xlink:to="loc_us-gaap_DerivativeAssets_5cb5ea4b-31e8-4f96-96a4-7d2d7d3ea11a" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_PaymentsforStrategicVentureCompliance_66c7eaec-c0a3-487b-8ebb-571222b1482d" xlink:href="cf-20220930.xsd#cf_PaymentsforStrategicVentureCompliance"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_5c229256-67b7-4f97-ad75-587c4cfd2128" xlink:to="loc_cf_PaymentsforStrategicVentureCompliance_66c7eaec-c0a3-487b-8ebb-571222b1482d" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_95747a66-3b6d-4137-87f2-aed35ad95e6a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_5c229256-67b7-4f97-ad75-587c4cfd2128" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_95747a66-3b6d-4137-87f2-aed35ad95e6a" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_50d82260-81da-4dc9-84ec-bc62127531ba" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByMeasurementFrequencyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_95747a66-3b6d-4137-87f2-aed35ad95e6a" xlink:to="loc_us-gaap_FairValueByMeasurementFrequencyAxis_50d82260-81da-4dc9-84ec-bc62127531ba" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_50d82260-81da-4dc9-84ec-bc62127531ba_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_50d82260-81da-4dc9-84ec-bc62127531ba" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_50d82260-81da-4dc9-84ec-bc62127531ba_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_c1b4a4b8-6685-4b22-a113-f72fa138e2c6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_50d82260-81da-4dc9-84ec-bc62127531ba" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_c1b4a4b8-6685-4b22-a113-f72fa138e2c6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember_dc272689-7fce-462c-9133-15f7495808c8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsRecurringMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_c1b4a4b8-6685-4b22-a113-f72fa138e2c6" xlink:to="loc_us-gaap_FairValueMeasurementsRecurringMember_dc272689-7fce-462c-9133-15f7495808c8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_16c44c1a-c79a-4c62-b41e-e7d729120ccf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_95747a66-3b6d-4137-87f2-aed35ad95e6a" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_16c44c1a-c79a-4c62-b41e-e7d729120ccf" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_16c44c1a-c79a-4c62-b41e-e7d729120ccf_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_16c44c1a-c79a-4c62-b41e-e7d729120ccf" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_16c44c1a-c79a-4c62-b41e-e7d729120ccf_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_733ad97b-c1f4-4209-a869-027145a229e8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_16c44c1a-c79a-4c62-b41e-e7d729120ccf" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_733ad97b-c1f4-4209-a869-027145a229e8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_0d7d5923-6a11-480d-8fc1-13b9c8921395" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_733ad97b-c1f4-4209-a869-027145a229e8" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_0d7d5923-6a11-480d-8fc1-13b9c8921395" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_6dc1475d-cdac-4536-bff5-105fec4025ea" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_733ad97b-c1f4-4209-a869-027145a229e8" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_6dc1475d-cdac-4536-bff5-105fec4025ea" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_f37ad819-7ad4-4282-adef-942fa523f95f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_733ad97b-c1f4-4209-a869-027145a229e8" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_f37ad819-7ad4-4282-adef-942fa523f95f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementBasisAxis_b03f3b14-452c-4244-9bf8-17fc03032f41" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByMeasurementBasisAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_95747a66-3b6d-4137-87f2-aed35ad95e6a" xlink:to="loc_us-gaap_FairValueByMeasurementBasisAxis_b03f3b14-452c-4244-9bf8-17fc03032f41" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_b03f3b14-452c-4244-9bf8-17fc03032f41_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_b03f3b14-452c-4244-9bf8-17fc03032f41" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_b03f3b14-452c-4244-9bf8-17fc03032f41_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosureItemAmountsDomain_fccd7522-7edb-4e53-8e3e-11e4bbb592bd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueDisclosureItemAmountsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_b03f3b14-452c-4244-9bf8-17fc03032f41" xlink:to="loc_us-gaap_FairValueDisclosureItemAmountsDomain_fccd7522-7edb-4e53-8e3e-11e4bbb592bd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_638eb4c3-1b30-4b5c-9723-a73018021c78" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_fccd7522-7edb-4e53-8e3e-11e4bbb592bd" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_638eb4c3-1b30-4b5c-9723-a73018021c78" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_c3fbfe1c-cafa-4733-bad5-e007777427b4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EstimateOfFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_638eb4c3-1b30-4b5c-9723-a73018021c78" xlink:to="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_c3fbfe1c-cafa-4733-bad5-e007777427b4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_e2af8811-37a6-4178-af48-e5878197cb71" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CarryingReportedAmountFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_638eb4c3-1b30-4b5c-9723-a73018021c78" xlink:to="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_e2af8811-37a6-4178-af48-e5878197cb71" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cfindustries.com/role/IncomeTaxesIncomesTaxesDetails" xlink:type="simple" xlink:href="cf-20220930.xsd#IncomeTaxesIncomesTaxesDetails"/>
  <link:definitionLink xlink:role="http://www.cfindustries.com/role/IncomeTaxesIncomesTaxesDetails" xlink:type="extended" id="ie6858f88300e4b959a86a8097e71acca_IncomeTaxesIncomesTaxesDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLossCarryforwardsLineItems_783e000e-0ac2-4d2f-a325-5fcc58794120" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLossCarryforwardsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_ab265483-fdf3-4492-bad6-01caecccefe6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_783e000e-0ac2-4d2f-a325-5fcc58794120" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_ab265483-fdf3-4492-bad6-01caecccefe6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_e19d60a9-82a2-4a0c-bd15-68fa49d5402e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EffectiveIncomeTaxRateContinuingOperations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_783e000e-0ac2-4d2f-a325-5fcc58794120" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_e19d60a9-82a2-4a0c-bd15-68fa49d5402e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationTaxSettlements_b404a929-8a02-4d68-b304-37af2f7a4f14" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxReconciliationTaxSettlements"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_783e000e-0ac2-4d2f-a325-5fcc58794120" xlink:to="loc_us-gaap_IncomeTaxReconciliationTaxSettlements_b404a929-8a02-4d68-b304-37af2f7a4f14" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_653b4229-d233-4fde-b0df-d7e5bc259676" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_783e000e-0ac2-4d2f-a325-5fcc58794120" xlink:to="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_653b4229-d233-4fde-b0df-d7e5bc259676" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_EffectiveIncomeTaxRateReconciliationPeriodIncreasedecreaseDueToNoncontrollingInterest_d812e084-60dc-452c-8059-b01e6c5c19bb" xlink:href="cf-20220930.xsd#cf_EffectiveIncomeTaxRateReconciliationPeriodIncreasedecreaseDueToNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_783e000e-0ac2-4d2f-a325-5fcc58794120" xlink:to="loc_cf_EffectiveIncomeTaxRateReconciliationPeriodIncreasedecreaseDueToNoncontrollingInterest_d812e084-60dc-452c-8059-b01e6c5c19bb" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_3618b3f3-db84-4820-baa8-c81b25691c06" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EffectiveIncomeTaxRateContinuingOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationShareBasedCompensationExcessTaxBenefitAmount_32d5eb93-dae6-4a04-a880-2e404d72ebfe" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationShareBasedCompensationExcessTaxBenefitAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_783e000e-0ac2-4d2f-a325-5fcc58794120" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationShareBasedCompensationExcessTaxBenefitAmount_32d5eb93-dae6-4a04-a880-2e404d72ebfe" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationTaxSettlementsForeign_4d58f205-99cd-4e72-89a2-d2ca996b3ea2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxReconciliationTaxSettlementsForeign"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_783e000e-0ac2-4d2f-a325-5fcc58794120" xlink:to="loc_us-gaap_IncomeTaxReconciliationTaxSettlementsForeign_4d58f205-99cd-4e72-89a2-d2ca996b3ea2" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExaminationLiabilityRefundAdjustmentFromSettlementWithTaxingAuthority_9437a9b1-8b9e-4827-8db6-5ae1fb626159" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxExaminationLiabilityRefundAdjustmentFromSettlementWithTaxingAuthority"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_783e000e-0ac2-4d2f-a325-5fcc58794120" xlink:to="loc_us-gaap_IncomeTaxExaminationLiabilityRefundAdjustmentFromSettlementWithTaxingAuthority_9437a9b1-8b9e-4827-8db6-5ae1fb626159" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExaminationInterestExpense_1f5befd8-31bd-4f1f-a536-5956a612b1ee" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxExaminationInterestExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_783e000e-0ac2-4d2f-a325-5fcc58794120" xlink:to="loc_us-gaap_IncomeTaxExaminationInterestExpense_1f5befd8-31bd-4f1f-a536-5956a612b1ee" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReceivable_8791ad81-7517-4443-a8e1-dab597e665ca" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxReceivable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_783e000e-0ac2-4d2f-a325-5fcc58794120" xlink:to="loc_us-gaap_IncomeTaxReceivable_8791ad81-7517-4443-a8e1-dab597e665ca" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrecognizedTaxBenefitsInterestOnIncomeTaxesAccrued_885e1fab-4cb0-4adf-a8d0-c346eabbc563" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_UnrecognizedTaxBenefitsInterestOnIncomeTaxesAccrued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_783e000e-0ac2-4d2f-a325-5fcc58794120" xlink:to="loc_us-gaap_UnrecognizedTaxBenefitsInterestOnIncomeTaxesAccrued_885e1fab-4cb0-4adf-a8d0-c346eabbc563" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions_11fdd433-eb11-4616-9371-195f5f8d7bbc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_783e000e-0ac2-4d2f-a325-5fcc58794120" xlink:to="loc_us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions_11fdd433-eb11-4616-9371-195f5f8d7bbc" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrecognizedTaxBenefits_b2f56a84-14e6-4727-8c44-528f2499b837" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_UnrecognizedTaxBenefits"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_783e000e-0ac2-4d2f-a325-5fcc58794120" xlink:to="loc_us-gaap_UnrecognizedTaxBenefits_b2f56a84-14e6-4727-8c44-528f2499b837" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxesReceivableNoncurrent_7293fed1-9f45-4f1d-82fc-f16968d20296" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxesReceivableNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_783e000e-0ac2-4d2f-a325-5fcc58794120" xlink:to="loc_us-gaap_IncomeTaxesReceivableNoncurrent_7293fed1-9f45-4f1d-82fc-f16968d20296" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedIncomeTaxesNoncurrent_3008a72a-8ee0-4e7a-aede-4924871b67db" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedIncomeTaxesNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_783e000e-0ac2-4d2f-a325-5fcc58794120" xlink:to="loc_us-gaap_AccruedIncomeTaxesNoncurrent_3008a72a-8ee0-4e7a-aede-4924871b67db" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrecognizedTaxBenefitsIncomeTaxPenaltiesAccrued_a1d0594f-87be-4157-8dae-bb14ff8bdfe0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_UnrecognizedTaxBenefitsIncomeTaxPenaltiesAccrued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_783e000e-0ac2-4d2f-a325-5fcc58794120" xlink:to="loc_us-gaap_UnrecognizedTaxBenefitsIncomeTaxPenaltiesAccrued_a1d0594f-87be-4157-8dae-bb14ff8bdfe0" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExaminationPenaltiesAndInterestAccrued_098a3456-8013-4550-8abd-844720a44f25" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxExaminationPenaltiesAndInterestAccrued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_783e000e-0ac2-4d2f-a325-5fcc58794120" xlink:to="loc_us-gaap_IncomeTaxExaminationPenaltiesAndInterestAccrued_098a3456-8013-4550-8abd-844720a44f25" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationTaxContingenciesForeign_117bc4f2-596f-4e93-a5b6-54d4d810e70f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxReconciliationTaxContingenciesForeign"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_783e000e-0ac2-4d2f-a325-5fcc58794120" xlink:to="loc_us-gaap_IncomeTaxReconciliationTaxContingenciesForeign_117bc4f2-596f-4e93-a5b6-54d4d810e70f" xlink:type="arc" order="18"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExaminationEstimateOfPossibleLoss_caa2c0cf-dc2b-48fc-a35b-e2929818af18" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxExaminationEstimateOfPossibleLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_783e000e-0ac2-4d2f-a325-5fcc58794120" xlink:to="loc_us-gaap_IncomeTaxExaminationEstimateOfPossibleLoss_caa2c0cf-dc2b-48fc-a35b-e2929818af18" xlink:type="arc" order="19"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_UnrecognizedTaxBenefitsEstimatedInterestOnIncomeTaxesAccruedNetOfTaxes_c5e88cbb-2bd7-4f0c-b3fa-75816139f076" xlink:href="cf-20220930.xsd#cf_UnrecognizedTaxBenefitsEstimatedInterestOnIncomeTaxesAccruedNetOfTaxes"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_783e000e-0ac2-4d2f-a325-5fcc58794120" xlink:to="loc_cf_UnrecognizedTaxBenefitsEstimatedInterestOnIncomeTaxesAccruedNetOfTaxes_c5e88cbb-2bd7-4f0c-b3fa-75816139f076" xlink:type="arc" order="20"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_IncomeTaxExaminationInterestExpenseNetOfTaxes_9a4467f0-7d57-4ab4-b030-591edeb7587f" xlink:href="cf-20220930.xsd#cf_IncomeTaxExaminationInterestExpenseNetOfTaxes"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_783e000e-0ac2-4d2f-a325-5fcc58794120" xlink:to="loc_cf_IncomeTaxExaminationInterestExpenseNetOfTaxes_9a4467f0-7d57-4ab4-b030-591edeb7587f" xlink:type="arc" order="21"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_a45e0e15-a7b2-48f6-9318-117090bf27c7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_783e000e-0ac2-4d2f-a325-5fcc58794120" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_a45e0e15-a7b2-48f6-9318-117090bf27c7" xlink:type="arc" order="22"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExaminationPenaltiesExpense_710e563d-8734-48b5-b18d-105f85f35453" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxExaminationPenaltiesExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_783e000e-0ac2-4d2f-a325-5fcc58794120" xlink:to="loc_us-gaap_IncomeTaxExaminationPenaltiesExpense_710e563d-8734-48b5-b18d-105f85f35453" xlink:type="arc" order="23"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExaminationIncreaseDecreaseInLiabilityFromPriorYear_3f12d9d2-547b-4eff-8ccc-3a19f42d61cf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxExaminationIncreaseDecreaseInLiabilityFromPriorYear"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_783e000e-0ac2-4d2f-a325-5fcc58794120" xlink:to="loc_us-gaap_IncomeTaxExaminationIncreaseDecreaseInLiabilityFromPriorYear_3f12d9d2-547b-4eff-8ccc-3a19f42d61cf" xlink:type="arc" order="24"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLossCarryforwardsTable_361e99a8-867d-4621-9fbe-33c0ee13262a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLossCarryforwardsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_783e000e-0ac2-4d2f-a325-5fcc58794120" xlink:to="loc_us-gaap_OperatingLossCarryforwardsTable_361e99a8-867d-4621-9fbe-33c0ee13262a" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityAxis_d0ecf8c5-a4d5-4780-80a8-f33792f9ff0b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxAuthorityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_OperatingLossCarryforwardsTable_361e99a8-867d-4621-9fbe-33c0ee13262a" xlink:to="loc_us-gaap_IncomeTaxAuthorityAxis_d0ecf8c5-a4d5-4780-80a8-f33792f9ff0b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_d0ecf8c5-a4d5-4780-80a8-f33792f9ff0b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxAuthorityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_d0ecf8c5-a4d5-4780-80a8-f33792f9ff0b" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_d0ecf8c5-a4d5-4780-80a8-f33792f9ff0b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_95d7339c-5440-44a6-b13c-ea0344919c27" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxAuthorityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_d0ecf8c5-a4d5-4780-80a8-f33792f9ff0b" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_95d7339c-5440-44a6-b13c-ea0344919c27" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCountryMember_35b80bda-f6cb-4686-b0f5-de113b01873d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ForeignCountryMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_95d7339c-5440-44a6-b13c-ea0344919c27" xlink:to="loc_us-gaap_ForeignCountryMember_35b80bda-f6cb-4686-b0f5-de113b01873d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DomesticCountryMember_5c46d857-1c05-45fe-ae8f-aa1571151c45" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DomesticCountryMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_95d7339c-5440-44a6-b13c-ea0344919c27" xlink:to="loc_us-gaap_DomesticCountryMember_5c46d857-1c05-45fe-ae8f-aa1571151c45" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityNameAxis_0147ce4e-700e-45a7-8064-ff63544db3d0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxAuthorityNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_OperatingLossCarryforwardsTable_361e99a8-867d-4621-9fbe-33c0ee13262a" xlink:to="loc_us-gaap_IncomeTaxAuthorityNameAxis_0147ce4e-700e-45a7-8064-ff63544db3d0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityNameDomain_0147ce4e-700e-45a7-8064-ff63544db3d0_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxAuthorityNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeTaxAuthorityNameAxis_0147ce4e-700e-45a7-8064-ff63544db3d0" xlink:to="loc_us-gaap_IncomeTaxAuthorityNameDomain_0147ce4e-700e-45a7-8064-ff63544db3d0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityNameDomain_ca083f7c-e2de-4e18-9e54-7cb7297125fd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxAuthorityNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeTaxAuthorityNameAxis_0147ce4e-700e-45a7-8064-ff63544db3d0" xlink:to="loc_us-gaap_IncomeTaxAuthorityNameDomain_ca083f7c-e2de-4e18-9e54-7cb7297125fd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CanadaRevenueAgencyMember_6fb45295-1ef4-4e19-a0e8-99c884506099" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CanadaRevenueAgencyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityNameDomain_ca083f7c-e2de-4e18-9e54-7cb7297125fd" xlink:to="loc_us-gaap_CanadaRevenueAgencyMember_6fb45295-1ef4-4e19-a0e8-99c884506099" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxPeriodAxis_53e90196-1126-4c29-8de5-30e6a54e1ce1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TaxPeriodAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_OperatingLossCarryforwardsTable_361e99a8-867d-4621-9fbe-33c0ee13262a" xlink:to="loc_us-gaap_TaxPeriodAxis_53e90196-1126-4c29-8de5-30e6a54e1ce1" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxPeriodDomain_53e90196-1126-4c29-8de5-30e6a54e1ce1_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TaxPeriodDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TaxPeriodAxis_53e90196-1126-4c29-8de5-30e6a54e1ce1" xlink:to="loc_us-gaap_TaxPeriodDomain_53e90196-1126-4c29-8de5-30e6a54e1ce1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxPeriodDomain_f1bafcf9-f831-4488-bbf9-7af20c10406e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TaxPeriodDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TaxPeriodAxis_53e90196-1126-4c29-8de5-30e6a54e1ce1" xlink:to="loc_us-gaap_TaxPeriodDomain_f1bafcf9-f831-4488-bbf9-7af20c10406e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_TaxYears20062011Member_92f8f018-bbf5-469e-ae20-0f3b6acd1848" xlink:href="cf-20220930.xsd#cf_TaxYears20062011Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TaxPeriodDomain_f1bafcf9-f831-4488-bbf9-7af20c10406e" xlink:to="loc_cf_TaxYears20062011Member_92f8f018-bbf5-469e-ae20-0f3b6acd1848" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_TaxYears2012AndAfterMember_cbaaaece-4dce-4e58-b384-2a9d9fddd282" xlink:href="cf-20220930.xsd#cf_TaxYears2012AndAfterMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TaxPeriodDomain_f1bafcf9-f831-4488-bbf9-7af20c10406e" xlink:to="loc_cf_TaxYears2012AndAfterMember_cbaaaece-4dce-4e58-b384-2a9d9fddd282" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_TaxYear2012AndAfterMember_ba45c8d4-6b79-4c8f-99a9-91ffca3f3dc4" xlink:href="cf-20220930.xsd#cf_TaxYear2012AndAfterMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TaxPeriodDomain_f1bafcf9-f831-4488-bbf9-7af20c10406e" xlink:to="loc_cf_TaxYear2012AndAfterMember_ba45c8d4-6b79-4c8f-99a9-91ffca3f3dc4" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cfindustries.com/role/FinancingAgreementsDetails" xlink:type="simple" xlink:href="cf-20220930.xsd#FinancingAgreementsDetails"/>
  <link:definitionLink xlink:role="http://www.cfindustries.com/role/FinancingAgreementsDetails" xlink:type="extended" id="iea792149dc324b7bb61de7780a6de295_FinancingAgreementsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_968c4276-82d4-4548-b026-c11b40fd72e4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_990b5aa0-20ae-4dff-ace7-7714f98a1ce5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_968c4276-82d4-4548-b026-c11b40fd72e4" xlink:to="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_990b5aa0-20ae-4dff-ace7-7714f98a1ce5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_ec530983-ed67-4639-b817-9922ce98c98c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_968c4276-82d4-4548-b026-c11b40fd72e4" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_ec530983-ed67-4639-b817-9922ce98c98c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentsAbstract_53b293fa-1a0d-4778-99b4-105d365dc2df" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentsAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_968c4276-82d4-4548-b026-c11b40fd72e4" xlink:to="loc_us-gaap_DebtInstrumentsAbstract_53b293fa-1a0d-4778-99b4-105d365dc2df" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_349fe490-2178-4b35-a03b-0b8817597867" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentInterestRateEffectivePercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_53b293fa-1a0d-4778-99b4-105d365dc2df" xlink:to="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_349fe490-2178-4b35-a03b-0b8817597867" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_069b005f-60e5-44bd-9fce-cf488604c751" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_53b293fa-1a0d-4778-99b4-105d365dc2df" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_069b005f-60e5-44bd-9fce-cf488604c751" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_93be0302-19e4-495c-84fd-60562e9351a7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_53b293fa-1a0d-4778-99b4-105d365dc2df" xlink:to="loc_us-gaap_LongTermDebt_93be0302-19e4-495c-84fd-60562e9351a7" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscount_f183e0c0-a90a-4aab-b879-382ebc0ea5df" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentUnamortizedDiscount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_53b293fa-1a0d-4778-99b4-105d365dc2df" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscount_f183e0c0-a90a-4aab-b879-382ebc0ea5df" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnamortizedDebtIssuanceExpense_4240bc06-8669-4ee7-912a-96477f74f4ba" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_UnamortizedDebtIssuanceExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_53b293fa-1a0d-4778-99b4-105d365dc2df" xlink:to="loc_us-gaap_UnamortizedDebtIssuanceExpense_4240bc06-8669-4ee7-912a-96477f74f4ba" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_2b786302-08e0-4a90-9a6d-713d63b310f7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_53b293fa-1a0d-4778-99b4-105d365dc2df" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_2b786302-08e0-4a90-9a6d-713d63b310f7" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityFairValueOfAmountOutstanding_b8c9208d-4d30-4973-9e40-3e1b1cba0463" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCreditFacilityFairValueOfAmountOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_968c4276-82d4-4548-b026-c11b40fd72e4" xlink:to="loc_us-gaap_LineOfCreditFacilityFairValueOfAmountOutstanding_b8c9208d-4d30-4973-9e40-3e1b1cba0463" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_ScheduleOfDebtInstrumentsTable_2a9dcc7e-5cc7-4079-bd7e-f1d29735ff0f" xlink:href="cf-20220930.xsd#cf_ScheduleOfDebtInstrumentsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_968c4276-82d4-4548-b026-c11b40fd72e4" xlink:to="loc_cf_ScheduleOfDebtInstrumentsTable_2a9dcc7e-5cc7-4079-bd7e-f1d29735ff0f" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_bb5f2a6a-4423-499a-a169-0c786e6c1160" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_cf_ScheduleOfDebtInstrumentsTable_2a9dcc7e-5cc7-4079-bd7e-f1d29735ff0f" xlink:to="loc_srt_RangeAxis_bb5f2a6a-4423-499a-a169-0c786e6c1160" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_bb5f2a6a-4423-499a-a169-0c786e6c1160_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_bb5f2a6a-4423-499a-a169-0c786e6c1160" xlink:to="loc_srt_RangeMember_bb5f2a6a-4423-499a-a169-0c786e6c1160_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_5ebfe978-7146-4ca3-ad30-6186e3adb3ba" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_bb5f2a6a-4423-499a-a169-0c786e6c1160" xlink:to="loc_srt_RangeMember_5ebfe978-7146-4ca3-ad30-6186e3adb3ba" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_31f8167e-4a04-4da8-8bcf-dd52c41b210c" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_5ebfe978-7146-4ca3-ad30-6186e3adb3ba" xlink:to="loc_srt_MaximumMember_31f8167e-4a04-4da8-8bcf-dd52c41b210c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidatedEntitiesAxis_d2452e82-1d90-4204-a3b9-0b37fb7d4d88" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_cf_ScheduleOfDebtInstrumentsTable_2a9dcc7e-5cc7-4079-bd7e-f1d29735ff0f" xlink:to="loc_srt_ConsolidatedEntitiesAxis_d2452e82-1d90-4204-a3b9-0b37fb7d4d88" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidatedEntitiesDomain_d2452e82-1d90-4204-a3b9-0b37fb7d4d88_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ConsolidatedEntitiesAxis_d2452e82-1d90-4204-a3b9-0b37fb7d4d88" xlink:to="loc_srt_ConsolidatedEntitiesDomain_d2452e82-1d90-4204-a3b9-0b37fb7d4d88_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidatedEntitiesDomain_7a94d47a-330a-4c59-a3ef-e3825db0698e" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ConsolidatedEntitiesAxis_d2452e82-1d90-4204-a3b9-0b37fb7d4d88" xlink:to="loc_srt_ConsolidatedEntitiesDomain_7a94d47a-330a-4c59-a3ef-e3825db0698e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SubsidiariesMember_60875d04-8103-4126-92d8-610a1dbba197" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SubsidiariesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidatedEntitiesDomain_7a94d47a-330a-4c59-a3ef-e3825db0698e" xlink:to="loc_srt_SubsidiariesMember_60875d04-8103-4126-92d8-610a1dbba197" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_ae8736ff-4048-4477-ba1c-cbe360b09ab0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_cf_ScheduleOfDebtInstrumentsTable_2a9dcc7e-5cc7-4079-bd7e-f1d29735ff0f" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_ae8736ff-4048-4477-ba1c-cbe360b09ab0" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_ae8736ff-4048-4477-ba1c-cbe360b09ab0_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_ae8736ff-4048-4477-ba1c-cbe360b09ab0" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_ae8736ff-4048-4477-ba1c-cbe360b09ab0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_087cc17f-80a7-4ca1-9c95-845c927db3fe" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_ae8736ff-4048-4477-ba1c-cbe360b09ab0" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_087cc17f-80a7-4ca1-9c95-845c927db3fe" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeniorNotesMember_043e3e54-824e-41a5-a530-1faa400d9c0f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_087cc17f-80a7-4ca1-9c95-845c927db3fe" xlink:to="loc_us-gaap_SeniorNotesMember_043e3e54-824e-41a5-a530-1faa400d9c0f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_f714dafc-06c4-4bfd-9b2f-fa5c2b059bf9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_cf_ScheduleOfDebtInstrumentsTable_2a9dcc7e-5cc7-4079-bd7e-f1d29735ff0f" xlink:to="loc_us-gaap_DebtInstrumentAxis_f714dafc-06c4-4bfd-9b2f-fa5c2b059bf9" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_f714dafc-06c4-4bfd-9b2f-fa5c2b059bf9_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_f714dafc-06c4-4bfd-9b2f-fa5c2b059bf9" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_f714dafc-06c4-4bfd-9b2f-fa5c2b059bf9_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_cef49c52-a3fe-4e88-bfe8-2c52ad46a4b2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_f714dafc-06c4-4bfd-9b2f-fa5c2b059bf9" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_cef49c52-a3fe-4e88-bfe8-2c52ad46a4b2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_SeniorNotes3.450PercentDue2023Member_f4c03d34-26fc-4313-8e59-113f57f81a79" xlink:href="cf-20220930.xsd#cf_SeniorNotes3.450PercentDue2023Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_cef49c52-a3fe-4e88-bfe8-2c52ad46a4b2" xlink:to="loc_cf_SeniorNotes3.450PercentDue2023Member_f4c03d34-26fc-4313-8e59-113f57f81a79" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_SeniorNotes5.150PercentDue2034Member_d88a998a-c386-4379-9b9d-9622fd952fa3" xlink:href="cf-20220930.xsd#cf_SeniorNotes5.150PercentDue2034Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_cef49c52-a3fe-4e88-bfe8-2c52ad46a4b2" xlink:to="loc_cf_SeniorNotes5.150PercentDue2034Member_d88a998a-c386-4379-9b9d-9622fd952fa3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_SeniorNotes4.950PercentDue2043Member_d6714ae8-3fdb-434b-8b7b-f8fa6445cd4d" xlink:href="cf-20220930.xsd#cf_SeniorNotes4.950PercentDue2043Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_cef49c52-a3fe-4e88-bfe8-2c52ad46a4b2" xlink:to="loc_cf_SeniorNotes4.950PercentDue2043Member_d6714ae8-3fdb-434b-8b7b-f8fa6445cd4d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_SeniorNotes5.375PercentDue2044Member_59b8469c-76ed-4701-807c-a95b1c78509e" xlink:href="cf-20220930.xsd#cf_SeniorNotes5.375PercentDue2044Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_cef49c52-a3fe-4e88-bfe8-2c52ad46a4b2" xlink:to="loc_cf_SeniorNotes5.375PercentDue2044Member_59b8469c-76ed-4701-807c-a95b1c78509e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_SeniorNotes4.500PercentDue2026Member_0467db2c-a126-46df-bc1c-bf67e4760cc8" xlink:href="cf-20220930.xsd#cf_SeniorNotes4.500PercentDue2026Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_cef49c52-a3fe-4e88-bfe8-2c52ad46a4b2" xlink:to="loc_cf_SeniorNotes4.500PercentDue2026Member_0467db2c-a126-46df-bc1c-bf67e4760cc8" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cfindustries.com/role/FinancingAgreementsNarrativeDetails" xlink:type="simple" xlink:href="cf-20220930.xsd#FinancingAgreementsNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.cfindustries.com/role/FinancingAgreementsNarrativeDetails" xlink:type="extended" id="i554eb46d99a34aea8ff04a542b7a4538_FinancingAgreementsNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_76bf322d-2457-4549-8e2f-005e74c584d6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_8d3d5d35-b8b0-4754-94e9-7b562db9e977" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_76bf322d-2457-4549-8e2f-005e74c584d6" xlink:to="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_8d3d5d35-b8b0-4754-94e9-7b562db9e977" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity_19ce1c38-8779-4a82-8207-7c07dab0414b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_76bf322d-2457-4549-8e2f-005e74c584d6" xlink:to="loc_us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity_19ce1c38-8779-4a82-8207-7c07dab0414b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LettersOfCreditOutstandingAmount_86dd1ebf-06bb-42eb-9648-fb4d4ac4230b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LettersOfCreditOutstandingAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_76bf322d-2457-4549-8e2f-005e74c584d6" xlink:to="loc_us-gaap_LettersOfCreditOutstandingAmount_86dd1ebf-06bb-42eb-9648-fb4d4ac4230b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCredit_2e6c9235-9d9c-4686-a383-5b9cf353936d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCredit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_76bf322d-2457-4549-8e2f-005e74c584d6" xlink:to="loc_us-gaap_LineOfCredit_2e6c9235-9d9c-4686-a383-5b9cf353936d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_67720455-ffe6-4cf8-ad8a-13bbab32fcf6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_76bf322d-2457-4549-8e2f-005e74c584d6" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_67720455-ffe6-4cf8-ad8a-13bbab32fcf6" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityFairValueOfAmountOutstanding_74ffa485-31d0-4db3-9987-d84efa6dfce3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCreditFacilityFairValueOfAmountOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_76bf322d-2457-4549-8e2f-005e74c584d6" xlink:to="loc_us-gaap_LineOfCreditFacilityFairValueOfAmountOutstanding_74ffa485-31d0-4db3-9987-d84efa6dfce3" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_76217a3a-997a-4de7-8b64-17ad5cd4bf0b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_76bf322d-2457-4549-8e2f-005e74c584d6" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_76217a3a-997a-4de7-8b64-17ad5cd4bf0b" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarlyRepaymentOfSeniorDebt_418b8d8a-e7bf-48ad-87d4-846bde4627cb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarlyRepaymentOfSeniorDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_76bf322d-2457-4549-8e2f-005e74c584d6" xlink:to="loc_us-gaap_EarlyRepaymentOfSeniorDebt_418b8d8a-e7bf-48ad-87d4-846bde4627cb" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ExtinguishmentOfDebtAmount_968ed920-a3fe-4050-9971-6dfd38132c91" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ExtinguishmentOfDebtAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_76bf322d-2457-4549-8e2f-005e74c584d6" xlink:to="loc_us-gaap_ExtinguishmentOfDebtAmount_968ed920-a3fe-4050-9971-6dfd38132c91" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityIncreaseDecreaseForPeriodNet_ed7d6be2-12c9-416f-946e-00ee0cb8ed48" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCreditFacilityIncreaseDecreaseForPeriodNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_76bf322d-2457-4549-8e2f-005e74c584d6" xlink:to="loc_us-gaap_LineOfCreditFacilityIncreaseDecreaseForPeriodNet_ed7d6be2-12c9-416f-946e-00ee0cb8ed48" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_b951eb80-8af1-4898-9105-1efa7c3eef0f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_76bf322d-2457-4549-8e2f-005e74c584d6" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_b951eb80-8af1-4898-9105-1efa7c3eef0f" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_49df0fe1-1a4d-4757-a032-2a3d0456ac6d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_76bf322d-2457-4549-8e2f-005e74c584d6" xlink:to="loc_us-gaap_DebtInstrumentTable_49df0fe1-1a4d-4757-a032-2a3d0456ac6d" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidatedEntitiesAxis_71572bd3-9c54-4f2f-82a4-4d75165fefff" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_49df0fe1-1a4d-4757-a032-2a3d0456ac6d" xlink:to="loc_srt_ConsolidatedEntitiesAxis_71572bd3-9c54-4f2f-82a4-4d75165fefff" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidatedEntitiesDomain_71572bd3-9c54-4f2f-82a4-4d75165fefff_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ConsolidatedEntitiesAxis_71572bd3-9c54-4f2f-82a4-4d75165fefff" xlink:to="loc_srt_ConsolidatedEntitiesDomain_71572bd3-9c54-4f2f-82a4-4d75165fefff_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidatedEntitiesDomain_89b2a872-5e01-473f-b7fe-e5b6c3e5b86e" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ConsolidatedEntitiesAxis_71572bd3-9c54-4f2f-82a4-4d75165fefff" xlink:to="loc_srt_ConsolidatedEntitiesDomain_89b2a872-5e01-473f-b7fe-e5b6c3e5b86e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SubsidiariesMember_8e79002c-175c-4f40-b635-a90d13a4afd6" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SubsidiariesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidatedEntitiesDomain_89b2a872-5e01-473f-b7fe-e5b6c3e5b86e" xlink:to="loc_srt_SubsidiariesMember_8e79002c-175c-4f40-b635-a90d13a4afd6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_7c746863-04ce-4cca-aa4d-07805557cfd4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_49df0fe1-1a4d-4757-a032-2a3d0456ac6d" xlink:to="loc_us-gaap_DebtInstrumentAxis_7c746863-04ce-4cca-aa4d-07805557cfd4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_7c746863-04ce-4cca-aa4d-07805557cfd4_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_7c746863-04ce-4cca-aa4d-07805557cfd4" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_7c746863-04ce-4cca-aa4d-07805557cfd4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_b5eda57c-7249-4e27-8bf0-16c7f65e5082" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_7c746863-04ce-4cca-aa4d-07805557cfd4" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_b5eda57c-7249-4e27-8bf0-16c7f65e5082" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_SeniorCreditAgreementMember_20359cfa-b8a2-455f-8ff9-350ae559d268" xlink:href="cf-20220930.xsd#cf_SeniorCreditAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_b5eda57c-7249-4e27-8bf0-16c7f65e5082" xlink:to="loc_cf_SeniorCreditAgreementMember_20359cfa-b8a2-455f-8ff9-350ae559d268" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_AmendmentNo.4totheThirdAmendedandRestatedRevolvingCreditAgreementMember_44479bcf-b50d-4636-a4ba-511ebb89058e" xlink:href="cf-20220930.xsd#cf_AmendmentNo.4totheThirdAmendedandRestatedRevolvingCreditAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_b5eda57c-7249-4e27-8bf0-16c7f65e5082" xlink:to="loc_cf_AmendmentNo.4totheThirdAmendedandRestatedRevolvingCreditAgreementMember_44479bcf-b50d-4636-a4ba-511ebb89058e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_July2016CreditAgreementAmendmentMember_65a6047d-e9cf-4ae6-9eb4-fc0fae0368d8" xlink:href="cf-20220930.xsd#cf_July2016CreditAgreementAmendmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_b5eda57c-7249-4e27-8bf0-16c7f65e5082" xlink:to="loc_cf_July2016CreditAgreementAmendmentMember_65a6047d-e9cf-4ae6-9eb4-fc0fae0368d8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_SeniorNotes3.450PercentDue2023Member_afbaf9e9-9123-4bb5-8793-0970de3819b5" xlink:href="cf-20220930.xsd#cf_SeniorNotes3.450PercentDue2023Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_b5eda57c-7249-4e27-8bf0-16c7f65e5082" xlink:to="loc_cf_SeniorNotes3.450PercentDue2023Member_afbaf9e9-9123-4bb5-8793-0970de3819b5" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_SeniorNotes3.400PercentDue2021MemberMember_f3dc9c95-2df8-4901-99e0-063a0570cb8a" xlink:href="cf-20220930.xsd#cf_SeniorNotes3.400PercentDue2021MemberMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_b5eda57c-7249-4e27-8bf0-16c7f65e5082" xlink:to="loc_cf_SeniorNotes3.400PercentDue2021MemberMember_f3dc9c95-2df8-4901-99e0-063a0570cb8a" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_7060bda8-9801-448b-a32a-2fc652080f98" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_49df0fe1-1a4d-4757-a032-2a3d0456ac6d" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_7060bda8-9801-448b-a32a-2fc652080f98" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_7060bda8-9801-448b-a32a-2fc652080f98_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_7060bda8-9801-448b-a32a-2fc652080f98" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_7060bda8-9801-448b-a32a-2fc652080f98_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_caeadc53-dfd3-4801-9700-5c596add89b5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_7060bda8-9801-448b-a32a-2fc652080f98" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_caeadc53-dfd3-4801-9700-5c596add89b5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeniorNotesMember_5578cac4-9c74-4ef2-a104-dcb2f52ccdf7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_caeadc53-dfd3-4801-9700-5c596add89b5" xlink:to="loc_us-gaap_SeniorNotesMember_5578cac4-9c74-4ef2-a104-dcb2f52ccdf7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditMember_7dabac0a-d341-4bf2-a558-2b9484005058" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCreditMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_caeadc53-dfd3-4801-9700-5c596add89b5" xlink:to="loc_us-gaap_LineOfCreditMember_7dabac0a-d341-4bf2-a558-2b9484005058" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_bf67441f-caae-4831-8b1b-0f55b7e132ac" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_49df0fe1-1a4d-4757-a032-2a3d0456ac6d" xlink:to="loc_srt_RangeAxis_bf67441f-caae-4831-8b1b-0f55b7e132ac" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_bf67441f-caae-4831-8b1b-0f55b7e132ac_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_bf67441f-caae-4831-8b1b-0f55b7e132ac" xlink:to="loc_srt_RangeMember_bf67441f-caae-4831-8b1b-0f55b7e132ac_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_b9b1d7d2-ebff-4694-800b-54860df79714" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_bf67441f-caae-4831-8b1b-0f55b7e132ac" xlink:to="loc_srt_RangeMember_b9b1d7d2-ebff-4694-800b-54860df79714" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_63a24d2a-45b5-42e4-b83b-1e910d200fdd" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_b9b1d7d2-ebff-4694-800b-54860df79714" xlink:to="loc_srt_MaximumMember_63a24d2a-45b5-42e4-b83b-1e910d200fdd" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtTypeAxis_252dad76-310a-424e-8b35-477c17943383" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShortTermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_49df0fe1-1a4d-4757-a032-2a3d0456ac6d" xlink:to="loc_us-gaap_ShortTermDebtTypeAxis_252dad76-310a-424e-8b35-477c17943383" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtTypeDomain_252dad76-310a-424e-8b35-477c17943383_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShortTermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ShortTermDebtTypeAxis_252dad76-310a-424e-8b35-477c17943383" xlink:to="loc_us-gaap_ShortTermDebtTypeDomain_252dad76-310a-424e-8b35-477c17943383_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtTypeDomain_7d070902-4870-4bba-8c13-7b2c53422ae9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShortTermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ShortTermDebtTypeAxis_252dad76-310a-424e-8b35-477c17943383" xlink:to="loc_us-gaap_ShortTermDebtTypeDomain_7d070902-4870-4bba-8c13-7b2c53422ae9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditMember_92031bc6-deb8-456e-a718-9db919bd725d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCreditMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShortTermDebtTypeDomain_7d070902-4870-4bba-8c13-7b2c53422ae9" xlink:to="loc_us-gaap_LineOfCreditMember_92031bc6-deb8-456e-a718-9db919bd725d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityAxis_4f09f145-74f1-4983-a112-9463096f351d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CreditFacilityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_49df0fe1-1a4d-4757-a032-2a3d0456ac6d" xlink:to="loc_us-gaap_CreditFacilityAxis_4f09f145-74f1-4983-a112-9463096f351d" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_4f09f145-74f1-4983-a112-9463096f351d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CreditFacilityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CreditFacilityAxis_4f09f145-74f1-4983-a112-9463096f351d" xlink:to="loc_us-gaap_CreditFacilityDomain_4f09f145-74f1-4983-a112-9463096f351d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_55536feb-2536-4fdc-8e72-d3d650a0c722" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CreditFacilityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CreditFacilityAxis_4f09f145-74f1-4983-a112-9463096f351d" xlink:to="loc_us-gaap_CreditFacilityDomain_55536feb-2536-4fdc-8e72-d3d650a0c722" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_17c90663-f5e5-4807-81f2-57f95d068127" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevolvingCreditFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CreditFacilityDomain_55536feb-2536-4fdc-8e72-d3d650a0c722" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_17c90663-f5e5-4807-81f2-57f95d068127" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LetterOfCreditMember_4652120e-9508-460b-b9b0-ffdc607ebc57" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LetterOfCreditMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CreditFacilityDomain_55536feb-2536-4fdc-8e72-d3d650a0c722" xlink:to="loc_us-gaap_LetterOfCreditMember_4652120e-9508-460b-b9b0-ffdc607ebc57" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cfindustries.com/role/DerivativeFinancialInstrumentsDetails" xlink:type="simple" xlink:href="cf-20220930.xsd#DerivativeFinancialInstrumentsDetails"/>
  <link:definitionLink xlink:role="http://www.cfindustries.com/role/DerivativeFinancialInstrumentsDetails" xlink:type="extended" id="ibb54ad2bcce54258bf9fb93dea4d505f_DerivativeFinancialInstrumentsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_80cc2e34-57ef-4c8e-898d-f0a28b0cf233" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentsGainLossLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrealizedGainLossOnDerivatives_03e8221b-bda3-42df-ba8c-50b8cc558702" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_UnrealizedGainLossOnDerivatives"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_80cc2e34-57ef-4c8e-898d-f0a28b0cf233" xlink:to="loc_us-gaap_UnrealizedGainLossOnDerivatives_03e8221b-bda3-42df-ba8c-50b8cc558702" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfDerivatives_588287ee-3dbb-4f8d-904b-fa52c937d207" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GainLossOnSaleOfDerivatives"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_80cc2e34-57ef-4c8e-898d-f0a28b0cf233" xlink:to="loc_us-gaap_GainLossOnSaleOfDerivatives_588287ee-3dbb-4f8d-904b-fa52c937d207" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeGainLossOnDerivativeNet_28b8027a-3c08-4d00-a25c-cebe016848aa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeGainLossOnDerivativeNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_80cc2e34-57ef-4c8e-898d-f0a28b0cf233" xlink:to="loc_us-gaap_DerivativeGainLossOnDerivativeNet_28b8027a-3c08-4d00-a25c-cebe016848aa" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_75c3395a-6720-4efc-b316-89654750973f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_80cc2e34-57ef-4c8e-898d-f0a28b0cf233" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_75c3395a-6720-4efc-b316-89654750973f" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_10a5e2e6-9959-45b6-a314-2609f66ba61e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_75c3395a-6720-4efc-b316-89654750973f" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_10a5e2e6-9959-45b6-a314-2609f66ba61e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_10a5e2e6-9959-45b6-a314-2609f66ba61e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_10a5e2e6-9959-45b6-a314-2609f66ba61e" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_10a5e2e6-9959-45b6-a314-2609f66ba61e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_44504f3f-20d8-4d56-abe0-619fa7d69e95" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_10a5e2e6-9959-45b6-a314-2609f66ba61e" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_44504f3f-20d8-4d56-abe0-619fa7d69e95" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EnergyRelatedDerivativeMember_204c36ae-27e9-43a8-91c6-e0f439ae5131" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EnergyRelatedDerivativeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_44504f3f-20d8-4d56-abe0-619fa7d69e95" xlink:to="loc_us-gaap_EnergyRelatedDerivativeMember_204c36ae-27e9-43a8-91c6-e0f439ae5131" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_b4b2ae2b-abf5-4246-adda-2ed2cd9c010d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_75c3395a-6720-4efc-b316-89654750973f" xlink:to="loc_us-gaap_HedgingDesignationAxis_b4b2ae2b-abf5-4246-adda-2ed2cd9c010d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_b4b2ae2b-abf5-4246-adda-2ed2cd9c010d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_b4b2ae2b-abf5-4246-adda-2ed2cd9c010d" xlink:to="loc_us-gaap_HedgingDesignationDomain_b4b2ae2b-abf5-4246-adda-2ed2cd9c010d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_68b55d4d-b56b-4e94-b644-b84ad4ad0942" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_b4b2ae2b-abf5-4246-adda-2ed2cd9c010d" xlink:to="loc_us-gaap_HedgingDesignationDomain_68b55d4d-b56b-4e94-b644-b84ad4ad0942" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NondesignatedMember_d4d69386-d1d1-434b-8878-638a32969278" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NondesignatedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_68b55d4d-b56b-4e94-b644-b84ad4ad0942" xlink:to="loc_us-gaap_NondesignatedMember_d4d69386-d1d1-434b-8878-638a32969278" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_015d6e64-347c-4595-9ff6-76be90cf24cc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_75c3395a-6720-4efc-b316-89654750973f" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_015d6e64-347c-4595-9ff6-76be90cf24cc" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_015d6e64-347c-4595-9ff6-76be90cf24cc_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_015d6e64-347c-4595-9ff6-76be90cf24cc" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_015d6e64-347c-4595-9ff6-76be90cf24cc_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_7ca50776-24d4-48b7-aca2-dca7222fe8ab" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_015d6e64-347c-4595-9ff6-76be90cf24cc" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_7ca50776-24d4-48b7-aca2-dca7222fe8ab" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfSalesMember_c3da3cb6-0842-4e2b-9f6b-461dd4e02a4d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CostOfSalesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_7ca50776-24d4-48b7-aca2-dca7222fe8ab" xlink:to="loc_us-gaap_CostOfSalesMember_c3da3cb6-0842-4e2b-9f6b-461dd4e02a4d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnusualOrInfrequentItemAxis_72c995dc-f500-4da0-ba5d-fcd6950dc388" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_UnusualOrInfrequentItemAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_75c3395a-6720-4efc-b316-89654750973f" xlink:to="loc_us-gaap_UnusualOrInfrequentItemAxis_72c995dc-f500-4da0-ba5d-fcd6950dc388" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnusualOrInfrequentItemDomain_72c995dc-f500-4da0-ba5d-fcd6950dc388_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_UnusualOrInfrequentItemDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_UnusualOrInfrequentItemAxis_72c995dc-f500-4da0-ba5d-fcd6950dc388" xlink:to="loc_us-gaap_UnusualOrInfrequentItemDomain_72c995dc-f500-4da0-ba5d-fcd6950dc388_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnusualOrInfrequentItemDomain_5be366d8-e2f7-49ad-8809-b3ae11929519" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_UnusualOrInfrequentItemDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_UnusualOrInfrequentItemAxis_72c995dc-f500-4da0-ba5d-fcd6950dc388" xlink:to="loc_us-gaap_UnusualOrInfrequentItemDomain_5be366d8-e2f7-49ad-8809-b3ae11929519" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_WinterStormUriMember_af506b35-5255-4d6c-bcd6-94ec288ead4d" xlink:href="cf-20220930.xsd#cf_WinterStormUriMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_UnusualOrInfrequentItemDomain_5be366d8-e2f7-49ad-8809-b3ae11929519" xlink:to="loc_cf_WinterStormUriMember_af506b35-5255-4d6c-bcd6-94ec288ead4d" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cfindustries.com/role/DerivativeFinancialInstrumentsDetails2" xlink:type="simple" xlink:href="cf-20220930.xsd#DerivativeFinancialInstrumentsDetails2"/>
  <link:definitionLink xlink:role="http://www.cfindustries.com/role/DerivativeFinancialInstrumentsDetails2" xlink:type="extended" id="i3bf6aa2a42a6453383691efc900ae807_DerivativeFinancialInstrumentsDetails2">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativesFairValueLineItems_c024e990-3b37-403b-a522-c72036f44148" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativesFairValueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssets_f8bfa6af-0cb3-4d49-a9f3-475b1d3ce2dc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_c024e990-3b37-403b-a522-c72036f44148" xlink:to="loc_us-gaap_DerivativeAssets_f8bfa6af-0cb3-4d49-a9f3-475b1d3ce2dc" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_eac3b275-c60f-4e6d-a643-19fcfd142825" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_c024e990-3b37-403b-a522-c72036f44148" xlink:to="loc_us-gaap_DerivativeLiabilities_eac3b275-c60f-4e6d-a643-19fcfd142825" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeCollateralRightToReclaimCash_45182d20-0e1d-4b41-a57a-8925a45d3cb4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeCollateralRightToReclaimCash"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_c024e990-3b37-403b-a522-c72036f44148" xlink:to="loc_us-gaap_DerivativeCollateralRightToReclaimCash_45182d20-0e1d-4b41-a57a-8925a45d3cb4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfDerivatives_6add801f-37d0-45a8-b531-c3e65ea8fbe3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GainLossOnSaleOfDerivatives"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_c024e990-3b37-403b-a522-c72036f44148" xlink:to="loc_us-gaap_GainLossOnSaleOfDerivatives_6add801f-37d0-45a8-b531-c3e65ea8fbe3" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_7706f199-2ab8-4683-bbd9-d09fdc4eba48" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_c024e990-3b37-403b-a522-c72036f44148" xlink:to="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_7706f199-2ab8-4683-bbd9-d09fdc4eba48" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_4992b7c2-f7df-40bc-9682-169a3157a183" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_7706f199-2ab8-4683-bbd9-d09fdc4eba48" xlink:to="loc_us-gaap_HedgingDesignationAxis_4992b7c2-f7df-40bc-9682-169a3157a183" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_4992b7c2-f7df-40bc-9682-169a3157a183_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_4992b7c2-f7df-40bc-9682-169a3157a183" xlink:to="loc_us-gaap_HedgingDesignationDomain_4992b7c2-f7df-40bc-9682-169a3157a183_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_6bd590a9-947c-4f84-b05b-6201a19cb06e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_4992b7c2-f7df-40bc-9682-169a3157a183" xlink:to="loc_us-gaap_HedgingDesignationDomain_6bd590a9-947c-4f84-b05b-6201a19cb06e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NondesignatedMember_5db7308d-ade2-4473-9ca4-c146a05b1657" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NondesignatedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_6bd590a9-947c-4f84-b05b-6201a19cb06e" xlink:to="loc_us-gaap_NondesignatedMember_5db7308d-ade2-4473-9ca4-c146a05b1657" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DesignatedAsHedgingInstrumentMember_c6879179-0048-40f3-8f7f-12029f3a8b8b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DesignatedAsHedgingInstrumentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_6bd590a9-947c-4f84-b05b-6201a19cb06e" xlink:to="loc_us-gaap_DesignatedAsHedgingInstrumentMember_c6879179-0048-40f3-8f7f-12029f3a8b8b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_db09d767-cfec-4ec3-8501-42f865bedf1c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_7706f199-2ab8-4683-bbd9-d09fdc4eba48" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_db09d767-cfec-4ec3-8501-42f865bedf1c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_db09d767-cfec-4ec3-8501-42f865bedf1c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_db09d767-cfec-4ec3-8501-42f865bedf1c" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_db09d767-cfec-4ec3-8501-42f865bedf1c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_ad2fab8e-9dad-4cdc-a835-97948d671a42" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_db09d767-cfec-4ec3-8501-42f865bedf1c" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_ad2fab8e-9dad-4cdc-a835-97948d671a42" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EnergyRelatedDerivativeMember_7a09797d-5ede-433b-9f12-be1e72e20f2b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EnergyRelatedDerivativeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_ad2fab8e-9dad-4cdc-a835-97948d671a42" xlink:to="loc_us-gaap_EnergyRelatedDerivativeMember_7a09797d-5ede-433b-9f12-be1e72e20f2b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnusualOrInfrequentItemAxis_9253ddf0-c1c3-4f82-a628-86def2eafb76" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_UnusualOrInfrequentItemAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_7706f199-2ab8-4683-bbd9-d09fdc4eba48" xlink:to="loc_us-gaap_UnusualOrInfrequentItemAxis_9253ddf0-c1c3-4f82-a628-86def2eafb76" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnusualOrInfrequentItemDomain_9253ddf0-c1c3-4f82-a628-86def2eafb76_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_UnusualOrInfrequentItemDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_UnusualOrInfrequentItemAxis_9253ddf0-c1c3-4f82-a628-86def2eafb76" xlink:to="loc_us-gaap_UnusualOrInfrequentItemDomain_9253ddf0-c1c3-4f82-a628-86def2eafb76_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnusualOrInfrequentItemDomain_fa738127-8659-4121-9050-0aa9ee021d16" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_UnusualOrInfrequentItemDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_UnusualOrInfrequentItemAxis_9253ddf0-c1c3-4f82-a628-86def2eafb76" xlink:to="loc_us-gaap_UnusualOrInfrequentItemDomain_fa738127-8659-4121-9050-0aa9ee021d16" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_WinterStormUriMember_891e02f8-13d2-48ad-b5bd-37cd74c490f6" xlink:href="cf-20220930.xsd#cf_WinterStormUriMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_UnusualOrInfrequentItemDomain_fa738127-8659-4121-9050-0aa9ee021d16" xlink:to="loc_cf_WinterStormUriMember_891e02f8-13d2-48ad-b5bd-37cd74c490f6" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cfindustries.com/role/DerivativeFinancialInstrumentsDetails3" xlink:type="simple" xlink:href="cf-20220930.xsd#DerivativeFinancialInstrumentsDetails3"/>
  <link:definitionLink xlink:role="http://www.cfindustries.com/role/DerivativeFinancialInstrumentsDetails3" xlink:type="extended" id="i4f37a9568f314a7b900061e8caf44843_DerivativeFinancialInstrumentsDetails3">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLineItems_32a222f2-c629-4695-95ad-0f22a961ad42" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssets_a9ad5145-79ec-4441-ae14-c24680aa76ed" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_32a222f2-c629-4695-95ad-0f22a961ad42" xlink:to="loc_us-gaap_DerivativeAssets_a9ad5145-79ec-4441-ae14-c24680aa76ed" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeCollateralObligationToReturnSecurities_83d33255-b274-4af9-9fd7-8198951c3e00" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeCollateralObligationToReturnSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_32a222f2-c629-4695-95ad-0f22a961ad42" xlink:to="loc_us-gaap_DerivativeCollateralObligationToReturnSecurities_83d33255-b274-4af9-9fd7-8198951c3e00" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeCollateralObligationToReturnCash_c8f79a59-a075-4386-8b34-b90932e352e7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeCollateralObligationToReturnCash"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_32a222f2-c629-4695-95ad-0f22a961ad42" xlink:to="loc_us-gaap_DerivativeCollateralObligationToReturnCash_c8f79a59-a075-4386-8b34-b90932e352e7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetFairValueOffsetAgainstCollateralNetOfNotSubjectToMasterNettingArrangementPolicyElection_2054d4d8-a91f-4726-98da-b21aa2210523" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeAssetFairValueOffsetAgainstCollateralNetOfNotSubjectToMasterNettingArrangementPolicyElection"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_32a222f2-c629-4695-95ad-0f22a961ad42" xlink:to="loc_us-gaap_DerivativeAssetFairValueOffsetAgainstCollateralNetOfNotSubjectToMasterNettingArrangementPolicyElection_2054d4d8-a91f-4726-98da-b21aa2210523" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_03a188ac-1bf3-4af0-a8fc-664df6b51eb0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_32a222f2-c629-4695-95ad-0f22a961ad42" xlink:to="loc_us-gaap_DerivativeLiabilities_03a188ac-1bf3-4af0-a8fc-664df6b51eb0" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityNotSubjectToMasterNettingArrangementDeduction_2becfd5e-8649-4f60-b936-c54a78ff4fec" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeLiabilityNotSubjectToMasterNettingArrangementDeduction"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_32a222f2-c629-4695-95ad-0f22a961ad42" xlink:to="loc_us-gaap_DerivativeLiabilityNotSubjectToMasterNettingArrangementDeduction_2becfd5e-8649-4f60-b936-c54a78ff4fec" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeCollateralRightToReclaimCash_c6178854-071b-4280-b8e0-8fc7532e9f95" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeCollateralRightToReclaimCash"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_32a222f2-c629-4695-95ad-0f22a961ad42" xlink:to="loc_us-gaap_DerivativeCollateralRightToReclaimCash_c6178854-071b-4280-b8e0-8fc7532e9f95" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityFairValueOffsetAgainstCollateralNetOfNotSubjectToMasterNettingArrangementPolicyElection_63d5081e-a976-4c15-ac91-8cafbefe531b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeLiabilityFairValueOffsetAgainstCollateralNetOfNotSubjectToMasterNettingArrangementPolicyElection"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_32a222f2-c629-4695-95ad-0f22a961ad42" xlink:to="loc_us-gaap_DerivativeLiabilityFairValueOffsetAgainstCollateralNetOfNotSubjectToMasterNettingArrangementPolicyElection_63d5081e-a976-4c15-ac91-8cafbefe531b" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetsLiabilitiesAtFairValueNet_34f554f8-f39c-4845-b152-1bf2e432fc4a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeAssetsLiabilitiesAtFairValueNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_32a222f2-c629-4695-95ad-0f22a961ad42" xlink:to="loc_us-gaap_DerivativeAssetsLiabilitiesAtFairValueNet_34f554f8-f39c-4845-b152-1bf2e432fc4a" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_NetDerivativeAssetLiabilityNotSubjecttoMasterNettingArrangementDeduction_da483342-41f0-45ef-802f-61b95eb815dc" xlink:href="cf-20220930.xsd#cf_NetDerivativeAssetLiabilityNotSubjecttoMasterNettingArrangementDeduction"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_32a222f2-c629-4695-95ad-0f22a961ad42" xlink:to="loc_cf_NetDerivativeAssetLiabilityNotSubjecttoMasterNettingArrangementDeduction_da483342-41f0-45ef-802f-61b95eb815dc" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_DerivativeCollateralObligationtoReturnCashRighttoReclaimCash_613c0146-2104-4fad-af46-7aade637011b" xlink:href="cf-20220930.xsd#cf_DerivativeCollateralObligationtoReturnCashRighttoReclaimCash"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_32a222f2-c629-4695-95ad-0f22a961ad42" xlink:to="loc_cf_DerivativeCollateralObligationtoReturnCashRighttoReclaimCash_613c0146-2104-4fad-af46-7aade637011b" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_NetDerivativeAssetLiabilityFairValueOffsetAgainstCollateralNetofNotSubjecttoMasterNettingArrangementPolicyElection_d2326f9c-9b2d-4d5b-9885-ab576bc5b32c" xlink:href="cf-20220930.xsd#cf_NetDerivativeAssetLiabilityFairValueOffsetAgainstCollateralNetofNotSubjecttoMasterNettingArrangementPolicyElection"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_32a222f2-c629-4695-95ad-0f22a961ad42" xlink:to="loc_cf_NetDerivativeAssetLiabilityFairValueOffsetAgainstCollateralNetofNotSubjecttoMasterNettingArrangementPolicyElection_d2326f9c-9b2d-4d5b-9885-ab576bc5b32c" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeTable_2ec16a0a-0e8a-494b-9799-1b42368ef328" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeLineItems_32a222f2-c629-4695-95ad-0f22a961ad42" xlink:to="loc_us-gaap_DerivativeTable_2ec16a0a-0e8a-494b-9799-1b42368ef328" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_16f4a1e7-21c8-4783-a59e-7259d47cf7b0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_2ec16a0a-0e8a-494b-9799-1b42368ef328" xlink:to="loc_us-gaap_HedgingDesignationAxis_16f4a1e7-21c8-4783-a59e-7259d47cf7b0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_16f4a1e7-21c8-4783-a59e-7259d47cf7b0_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_16f4a1e7-21c8-4783-a59e-7259d47cf7b0" xlink:to="loc_us-gaap_HedgingDesignationDomain_16f4a1e7-21c8-4783-a59e-7259d47cf7b0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_e8c9a2df-b181-4f62-b016-0639ccf49220" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_16f4a1e7-21c8-4783-a59e-7259d47cf7b0" xlink:to="loc_us-gaap_HedgingDesignationDomain_e8c9a2df-b181-4f62-b016-0639ccf49220" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NondesignatedMember_46703892-8cc1-44ad-9c40-f35d879e3019" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NondesignatedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_e8c9a2df-b181-4f62-b016-0639ccf49220" xlink:to="loc_us-gaap_NondesignatedMember_46703892-8cc1-44ad-9c40-f35d879e3019" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cfindustries.com/role/NoncontrollingInterestDetails" xlink:type="simple" xlink:href="cf-20220930.xsd#NoncontrollingInterestDetails"/>
  <link:definitionLink xlink:role="http://www.cfindustries.com/role/NoncontrollingInterestDetails" xlink:type="extended" id="iaba6a72198b341bdbf977dbeff6d6ea1_NoncontrollingInterestDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterestLineItems_07b479b0-187d-4439-b0cc-ce2fee69c103" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MinorityInterestLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterestOwnershipPercentageByNoncontrollingOwners_06e2687f-2664-4a34-b1e0-c4bbac01fa57" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MinorityInterestOwnershipPercentageByNoncontrollingOwners"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MinorityInterestLineItems_07b479b0-187d-4439-b0cc-ce2fee69c103" xlink:to="loc_us-gaap_MinorityInterestOwnershipPercentageByNoncontrollingOwners_06e2687f-2664-4a34-b1e0-c4bbac01fa57" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_MaximumAnnualGranularUreaTonsEligibleforPurchase_a7c8eb69-6a87-4628-80c1-d0f1fc186de4" xlink:href="cf-20220930.xsd#cf_MaximumAnnualGranularUreaTonsEligibleforPurchase"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MinorityInterestLineItems_07b479b0-187d-4439-b0cc-ce2fee69c103" xlink:to="loc_cf_MaximumAnnualGranularUreaTonsEligibleforPurchase_a7c8eb69-6a87-4628-80c1-d0f1fc186de4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_MaximumAnnualUANTonsEligibleforPurchase_4f72f8d5-6d71-4b61-97ca-90507ffc3097" xlink:href="cf-20220930.xsd#cf_MaximumAnnualUANTonsEligibleforPurchase"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MinorityInterestLineItems_07b479b0-187d-4439-b0cc-ce2fee69c103" xlink:to="loc_cf_MaximumAnnualUANTonsEligibleforPurchase_4f72f8d5-6d71-4b61-97ca-90507ffc3097" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterestDecreaseFromDistributionsToNoncontrollingInterestHolders_ea6ac318-95da-4d15-a841-73a59284514d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MinorityInterestDecreaseFromDistributionsToNoncontrollingInterestHolders"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MinorityInterestLineItems_07b479b0-187d-4439-b0cc-ce2fee69c103" xlink:to="loc_us-gaap_MinorityInterestDecreaseFromDistributionsToNoncontrollingInterestHolders_ea6ac318-95da-4d15-a841-73a59284514d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterestTable_06082205-f3c6-4387-8f4b-6402ce36a5fe" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MinorityInterestTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_MinorityInterestLineItems_07b479b0-187d-4439-b0cc-ce2fee69c103" xlink:to="loc_us-gaap_MinorityInterestTable_06082205-f3c6-4387-8f4b-6402ce36a5fe" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipAxis_a41cc244-2712-4595-bd0d-9ec95adccced" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_OwnershipAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_MinorityInterestTable_06082205-f3c6-4387-8f4b-6402ce36a5fe" xlink:to="loc_srt_OwnershipAxis_a41cc244-2712-4595-bd0d-9ec95adccced" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipDomain_a41cc244-2712-4595-bd0d-9ec95adccced_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_OwnershipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_OwnershipAxis_a41cc244-2712-4595-bd0d-9ec95adccced" xlink:to="loc_srt_OwnershipDomain_a41cc244-2712-4595-bd0d-9ec95adccced_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipDomain_ab9f4b47-a40d-4b22-abef-76e8acea7004" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_OwnershipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_OwnershipAxis_a41cc244-2712-4595-bd0d-9ec95adccced" xlink:to="loc_srt_OwnershipDomain_ab9f4b47-a40d-4b22-abef-76e8acea7004" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_CHSInc.Member_342ce747-cfb1-40bd-ab19-7744b51f22ed" xlink:href="cf-20220930.xsd#cf_CHSInc.Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_OwnershipDomain_ab9f4b47-a40d-4b22-abef-76e8acea7004" xlink:to="loc_cf_CHSInc.Member_342ce747-cfb1-40bd-ab19-7744b51f22ed" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_d02ed917-02c8-4aa5-ae00-c6860475f605" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_LegalEntityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_MinorityInterestTable_06082205-f3c6-4387-8f4b-6402ce36a5fe" xlink:to="loc_dei_LegalEntityAxis_d02ed917-02c8-4aa5-ae00-c6860475f605" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_d02ed917-02c8-4aa5-ae00-c6860475f605_default" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_d02ed917-02c8-4aa5-ae00-c6860475f605" xlink:to="loc_dei_EntityDomain_d02ed917-02c8-4aa5-ae00-c6860475f605_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_946b2738-1a4a-4892-ae9d-b82ae5aaf1c3" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_d02ed917-02c8-4aa5-ae00-c6860475f605" xlink:to="loc_dei_EntityDomain_946b2738-1a4a-4892-ae9d-b82ae5aaf1c3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_CFIndustriesNitrogenLLCMember_986d7f19-8c2c-4c92-b0fb-cb68778e6864" xlink:href="cf-20220930.xsd#cf_CFIndustriesNitrogenLLCMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_946b2738-1a4a-4892-ae9d-b82ae5aaf1c3" xlink:to="loc_cf_CFIndustriesNitrogenLLCMember_986d7f19-8c2c-4c92-b0fb-cb68778e6864" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_8b043a15-28ee-4d44-a313-462bdea9b986" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_MinorityInterestTable_06082205-f3c6-4387-8f4b-6402ce36a5fe" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_8b043a15-28ee-4d44-a313-462bdea9b986" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_8b043a15-28ee-4d44-a313-462bdea9b986_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_8b043a15-28ee-4d44-a313-462bdea9b986" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_8b043a15-28ee-4d44-a313-462bdea9b986_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_faae8f52-2233-4a2d-98bb-82c5b9bd36d0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_8b043a15-28ee-4d44-a313-462bdea9b986" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_faae8f52-2233-4a2d-98bb-82c5b9bd36d0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_97b62031-3c90-4fc6-82f6-5a7d65889ab8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_faae8f52-2233-4a2d-98bb-82c5b9bd36d0" xlink:to="loc_us-gaap_SubsequentEventMember_97b62031-3c90-4fc6-82f6-5a7d65889ab8" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cfindustries.com/role/NoncontrollingInterestDetails2" xlink:type="simple" xlink:href="cf-20220930.xsd#NoncontrollingInterestDetails2"/>
  <link:definitionLink xlink:role="http://www.cfindustries.com/role/NoncontrollingInterestDetails2" xlink:type="extended" id="i81df3db5dc8e4d0ab629a5f373368cbf_NoncontrollingInterestDetails2">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterestLineItems_3e32a68e-ac55-4015-8fd1-877c9c6fe2ae" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MinorityInterestLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MovementInMinorityInterestRollForward_d468aaed-ef99-411b-9702-ef4852b959b3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MovementInMinorityInterestRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MinorityInterestLineItems_3e32a68e-ac55-4015-8fd1-877c9c6fe2ae" xlink:to="loc_us-gaap_MovementInMinorityInterestRollForward_d468aaed-ef99-411b-9702-ef4852b959b3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterest_4e1fc04f-f300-4575-a8e7-1f1cc7e25ead" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MinorityInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MovementInMinorityInterestRollForward_d468aaed-ef99-411b-9702-ef4852b959b3" xlink:to="loc_us-gaap_MinorityInterest_4e1fc04f-f300-4575-a8e7-1f1cc7e25ead" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_92843303-c2ec-448d-87e8-db6f0c889224" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MovementInMinorityInterestRollForward_d468aaed-ef99-411b-9702-ef4852b959b3" xlink:to="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_92843303-c2ec-448d-87e8-db6f0c889224" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterestDecreaseFromDistributionsToNoncontrollingInterestHolders_0d03572c-1b5a-4002-b2c3-f413d9669f54" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MinorityInterestDecreaseFromDistributionsToNoncontrollingInterestHolders"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MovementInMinorityInterestRollForward_d468aaed-ef99-411b-9702-ef4852b959b3" xlink:to="loc_us-gaap_MinorityInterestDecreaseFromDistributionsToNoncontrollingInterestHolders_0d03572c-1b5a-4002-b2c3-f413d9669f54" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterest_370cf1e9-1807-404a-b8e3-3a7728866574" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MinorityInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_DistributionsPayableToMinorityInterestRollForward_658e0f4f-0206-4311-8a10-be5484a0ac99" xlink:href="cf-20220930.xsd#cf_DistributionsPayableToMinorityInterestRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MinorityInterestLineItems_3e32a68e-ac55-4015-8fd1-877c9c6fe2ae" xlink:to="loc_cf_DistributionsPayableToMinorityInterestRollForward_658e0f4f-0206-4311-8a10-be5484a0ac99" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_DistributionsPayableToMinorityInterest_e65fc418-b273-4160-ab62-de91fa75e83a" xlink:href="cf-20220930.xsd#cf_DistributionsPayableToMinorityInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cf_DistributionsPayableToMinorityInterestRollForward_658e0f4f-0206-4311-8a10-be5484a0ac99" xlink:to="loc_cf_DistributionsPayableToMinorityInterest_e65fc418-b273-4160-ab62-de91fa75e83a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_MinorityInterestDistributionsDeclaredAndPayableToNoncontrollingInterestHolders_fd9b722b-5e0d-4305-8579-d9342209ceba" xlink:href="cf-20220930.xsd#cf_MinorityInterestDistributionsDeclaredAndPayableToNoncontrollingInterestHolders"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cf_DistributionsPayableToMinorityInterestRollForward_658e0f4f-0206-4311-8a10-be5484a0ac99" xlink:to="loc_cf_MinorityInterestDistributionsDeclaredAndPayableToNoncontrollingInterestHolders_fd9b722b-5e0d-4305-8579-d9342209ceba" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_MinorityInterestDistributionsToNoncontrollingInterestHolders_9558c89c-9c1f-462c-81e1-384200f24ab8" xlink:href="cf-20220930.xsd#cf_MinorityInterestDistributionsToNoncontrollingInterestHolders"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cf_DistributionsPayableToMinorityInterestRollForward_658e0f4f-0206-4311-8a10-be5484a0ac99" xlink:to="loc_cf_MinorityInterestDistributionsToNoncontrollingInterestHolders_9558c89c-9c1f-462c-81e1-384200f24ab8" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_DistributionsPayableToMinorityInterest_40b23616-cfab-4946-aa4b-8e5b79b68c5b" xlink:href="cf-20220930.xsd#cf_DistributionsPayableToMinorityInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterestTable_88871d4d-2ef6-4ffb-b531-e73d94279a01" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MinorityInterestTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_MinorityInterestLineItems_3e32a68e-ac55-4015-8fd1-877c9c6fe2ae" xlink:to="loc_us-gaap_MinorityInterestTable_88871d4d-2ef6-4ffb-b531-e73d94279a01" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_cd8e8a2a-6451-44db-86b3-556f10b1a991" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_LegalEntityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_MinorityInterestTable_88871d4d-2ef6-4ffb-b531-e73d94279a01" xlink:to="loc_dei_LegalEntityAxis_cd8e8a2a-6451-44db-86b3-556f10b1a991" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_cd8e8a2a-6451-44db-86b3-556f10b1a991_default" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_cd8e8a2a-6451-44db-86b3-556f10b1a991" xlink:to="loc_dei_EntityDomain_cd8e8a2a-6451-44db-86b3-556f10b1a991_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_6decdc5a-f9a2-407c-996f-5cb27048a999" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_cd8e8a2a-6451-44db-86b3-556f10b1a991" xlink:to="loc_dei_EntityDomain_6decdc5a-f9a2-407c-996f-5cb27048a999" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_CFIndustriesNitrogenLLCMember_c8d55ac3-1b37-46b2-a7ab-d4975400269e" xlink:href="cf-20220930.xsd#cf_CFIndustriesNitrogenLLCMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_6decdc5a-f9a2-407c-996f-5cb27048a999" xlink:to="loc_cf_CFIndustriesNitrogenLLCMember_c8d55ac3-1b37-46b2-a7ab-d4975400269e" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cfindustries.com/role/StockholdersEquityDetails" xlink:type="simple" xlink:href="cf-20220930.xsd#StockholdersEquityDetails"/>
  <link:definitionLink xlink:role="http://www.cfindustries.com/role/StockholdersEquityDetails" xlink:type="extended" id="i6eb8439232464a69af6d696641f6034a_StockholdersEquityDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_7a0dbeed-8760-4f9d-88ce-fe423af4b2c3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_898f5727-fe25-48e2-9330-85b0a04608bc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_7a0dbeed-8760-4f9d-88ce-fe423af4b2c3" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_898f5727-fe25-48e2-9330-85b0a04608bc" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodBeforeTax_4a01fb67-f57a-4bcd-a5a8-7e05cdc592c1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_7a0dbeed-8760-4f9d-88ce-fe423af4b2c3" xlink:to="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodBeforeTax_4a01fb67-f57a-4bcd-a5a8-7e05cdc592c1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_OtherComprehensiveIncomeExchangeRateChangesAndDeferredTaxes_2281a11e-4803-4439-b3c2-96486e759a3f" xlink:href="cf-20220930.xsd#cf_OtherComprehensiveIncomeExchangeRateChangesAndDeferredTaxes"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_7a0dbeed-8760-4f9d-88ce-fe423af4b2c3" xlink:to="loc_cf_OtherComprehensiveIncomeExchangeRateChangesAndDeferredTaxes_2281a11e-4803-4439-b3c2-96486e759a3f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_e7f3a144-54f0-49f1-be3c-e7ceb1ab9e51" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_OtherComprehensiveIncomePensionAndOtherPostretirementBenefitPlansArisingDuringPeriodBeforeTax_3f172a81-d9b5-4cff-a836-89f7f26a9551" xlink:href="cf-20220930.xsd#cf_OtherComprehensiveIncomePensionAndOtherPostretirementBenefitPlansArisingDuringPeriodBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_7a0dbeed-8760-4f9d-88ce-fe423af4b2c3" xlink:to="loc_cf_OtherComprehensiveIncomePensionAndOtherPostretirementBenefitPlansArisingDuringPeriodBeforeTax_3f172a81-d9b5-4cff-a836-89f7f26a9551" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_4afd5560-0c55-45d6-8b97-345fe2354070" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_7a0dbeed-8760-4f9d-88ce-fe423af4b2c3" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_4afd5560-0c55-45d6-8b97-345fe2354070" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_3476345b-37b1-4b36-b363-4b50fca82605" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_4afd5560-0c55-45d6-8b97-345fe2354070" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_3476345b-37b1-4b36-b363-4b50fca82605" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_3476345b-37b1-4b36-b363-4b50fca82605_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_3476345b-37b1-4b36-b363-4b50fca82605" xlink:to="loc_us-gaap_EquityComponentDomain_3476345b-37b1-4b36-b363-4b50fca82605_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_3fbed0c7-c0e1-4533-844b-105dc8f05c68" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_3476345b-37b1-4b36-b363-4b50fca82605" xlink:to="loc_us-gaap_EquityComponentDomain_3fbed0c7-c0e1-4533-844b-105dc8f05c68" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedTranslationAdjustmentMember_0bb5e0e4-f736-4689-b5d3-48ae40aad530" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedTranslationAdjustmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_3fbed0c7-c0e1-4533-844b-105dc8f05c68" xlink:to="loc_us-gaap_AccumulatedTranslationAdjustmentMember_0bb5e0e4-f736-4689-b5d3-48ae40aad530" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedNetGainLossFromDesignatedOrQualifyingCashFlowHedgesMember_85700c0e-8213-40ae-b04d-ed8355b48a58" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedNetGainLossFromDesignatedOrQualifyingCashFlowHedgesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_3fbed0c7-c0e1-4533-844b-105dc8f05c68" xlink:to="loc_us-gaap_AccumulatedNetGainLossFromDesignatedOrQualifyingCashFlowHedgesMember_85700c0e-8213-40ae-b04d-ed8355b48a58" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember_a358376a-84fd-4e3f-a530-fe7d9a2abac6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_3fbed0c7-c0e1-4533-844b-105dc8f05c68" xlink:to="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember_a358376a-84fd-4e3f-a530-fe7d9a2abac6" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_3bc61dfd-3b17-4ef4-b372-cf348e8e0460" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_3fbed0c7-c0e1-4533-844b-105dc8f05c68" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_3bc61dfd-3b17-4ef4-b372-cf348e8e0460" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cfindustries.com/role/StockholdersEquityDetails2" xlink:type="simple" xlink:href="cf-20220930.xsd#StockholdersEquityDetails2"/>
  <link:definitionLink xlink:role="http://www.cfindustries.com/role/StockholdersEquityDetails2" xlink:type="extended" id="i80a81d83c4d04437ab62e005edd5c211_StockholdersEquityDetails2">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_56cb515f-154b-4aee-ad8d-24adbf8f967f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized_0bba6124-2cdd-46d3-9e98-b3c64347026a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_56cb515f-154b-4aee-ad8d-24adbf8f967f" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized_0bba6124-2cdd-46d3-9e98-b3c64347026a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_0dce0ba0-4a7f-46f3-9245-34110a14019f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockRepurchaseProgramAuthorizedAmount1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_56cb515f-154b-4aee-ad8d-24adbf8f967f" xlink:to="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_0dce0ba0-4a7f-46f3-9245-34110a14019f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchasedAndRetiredDuringPeriodShares_86cb0d13-4841-4605-b1a0-cb8f767d1e12" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockRepurchasedAndRetiredDuringPeriodShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_56cb515f-154b-4aee-ad8d-24adbf8f967f" xlink:to="loc_us-gaap_StockRepurchasedAndRetiredDuringPeriodShares_86cb0d13-4841-4605-b1a0-cb8f767d1e12" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodValue_1d90459f-aeab-41b0-9749-e95da517aa6d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockRepurchasedDuringPeriodValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_56cb515f-154b-4aee-ad8d-24adbf8f967f" xlink:to="loc_us-gaap_StockRepurchasedDuringPeriodValue_1d90459f-aeab-41b0-9749-e95da517aa6d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockSharesRetired_0653d207-0398-433e-9acb-cfd0a710c90b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TreasuryStockSharesRetired"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_56cb515f-154b-4aee-ad8d-24adbf8f967f" xlink:to="loc_us-gaap_TreasuryStockSharesRetired_0653d207-0398-433e-9acb-cfd0a710c90b" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_StockRepurchaseAccruedButUnpaid_c2a46796-f6b5-42a5-a53e-8aefe125d8ae" xlink:href="cf-20220930.xsd#cf_StockRepurchaseAccruedButUnpaid"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_56cb515f-154b-4aee-ad8d-24adbf8f967f" xlink:to="loc_cf_StockRepurchaseAccruedButUnpaid_c2a46796-f6b5-42a5-a53e-8aefe125d8ae" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_c42527b8-07db-40ff-9993-1de4ce721ae9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_56cb515f-154b-4aee-ad8d-24adbf8f967f" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_c42527b8-07db-40ff-9993-1de4ce721ae9" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis_dc38799e-f5d6-4113-8e65-1f061fd8fe7e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_c42527b8-07db-40ff-9993-1de4ce721ae9" xlink:to="loc_us-gaap_PlanNameAxis_dc38799e-f5d6-4113-8e65-1f061fd8fe7e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_dc38799e-f5d6-4113-8e65-1f061fd8fe7e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PlanNameAxis_dc38799e-f5d6-4113-8e65-1f061fd8fe7e" xlink:to="loc_us-gaap_PlanNameDomain_dc38799e-f5d6-4113-8e65-1f061fd8fe7e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_2007a9b6-52c0-4b09-9a1b-ed00c32bfd97" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PlanNameAxis_dc38799e-f5d6-4113-8e65-1f061fd8fe7e" xlink:to="loc_us-gaap_PlanNameDomain_2007a9b6-52c0-4b09-9a1b-ed00c32bfd97" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_A2022EquityAndIncentivePlanMember_f8d7b66f-6bc4-4b96-8d7b-866fad04b7dc" xlink:href="cf-20220930.xsd#cf_A2022EquityAndIncentivePlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_2007a9b6-52c0-4b09-9a1b-ed00c32bfd97" xlink:to="loc_cf_A2022EquityAndIncentivePlanMember_f8d7b66f-6bc4-4b96-8d7b-866fad04b7dc" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cfindustries.com/role/ContingenciesDetails" xlink:type="simple" xlink:href="cf-20220930.xsd#ContingenciesDetails"/>
  <link:definitionLink xlink:role="http://www.cfindustries.com/role/ContingenciesDetails" xlink:type="extended" id="if39cadbe44804808a92ca664aa3a295f_ContingenciesDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesLineItems_91a95893-5831-4fb9-9265-60ba51c13065" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LossContingenciesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_LossContingencyNumberofPeopleKilled_35dd6d01-f298-4f0d-8e06-643d75722754" xlink:href="cf-20220930.xsd#cf_LossContingencyNumberofPeopleKilled"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_91a95893-5831-4fb9-9265-60ba51c13065" xlink:to="loc_cf_LossContingencyNumberofPeopleKilled_35dd6d01-f298-4f0d-8e06-643d75722754" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_LossContingencyNumberofPeopleInjured_f7f02622-5dec-4d44-9f7d-43b20673d835" xlink:href="cf-20220930.xsd#cf_LossContingencyNumberofPeopleInjured"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_91a95893-5831-4fb9-9265-60ba51c13065" xlink:to="loc_cf_LossContingencyNumberofPeopleInjured_f7f02622-5dec-4d44-9f7d-43b20673d835" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyNumberOfPlaintiffs_a9345c02-e318-49d9-aedc-a1f3fc416f0c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LossContingencyNumberOfPlaintiffs"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_91a95893-5831-4fb9-9265-60ba51c13065" xlink:to="loc_us-gaap_LossContingencyNumberOfPlaintiffs_a9345c02-e318-49d9-aedc-a1f3fc416f0c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_LossContingencyNumberofEntitiesthatFiledClaims_d83374ae-893a-4efc-b45d-1d6cf15e9047" xlink:href="cf-20220930.xsd#cf_LossContingencyNumberofEntitiesthatFiledClaims"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_91a95893-5831-4fb9-9265-60ba51c13065" xlink:to="loc_cf_LossContingencyNumberofEntitiesthatFiledClaims_d83374ae-893a-4efc-b45d-1d6cf15e9047" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_LossContingencyNumberofPeoplethatFiledClaims_77fb1546-1b6b-43c9-9296-fbf64f1ea66e" xlink:href="cf-20220930.xsd#cf_LossContingencyNumberofPeoplethatFiledClaims"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_91a95893-5831-4fb9-9265-60ba51c13065" xlink:to="loc_cf_LossContingencyNumberofPeoplethatFiledClaims_77fb1546-1b6b-43c9-9296-fbf64f1ea66e" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_LossContingencyNumberofInsuranceCompaniesthatFiledClaims_e7eefc61-f5ab-4d50-940e-588745c00b97" xlink:href="cf-20220930.xsd#cf_LossContingencyNumberofInsuranceCompaniesthatFiledClaims"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_91a95893-5831-4fb9-9265-60ba51c13065" xlink:to="loc_cf_LossContingencyNumberofInsuranceCompaniesthatFiledClaims_e7eefc61-f5ab-4d50-940e-588745c00b97" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_Losscontingencynumberofmines_4def0691-9ea7-45d8-b2ea-373629edbf89" xlink:href="cf-20220930.xsd#cf_Losscontingencynumberofmines"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_91a95893-5831-4fb9-9265-60ba51c13065" xlink:to="loc_cf_Losscontingencynumberofmines_4def0691-9ea7-45d8-b2ea-373629edbf89" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_LossContingencyNumberOfProcessingFacilities_f0bb4edf-9693-4546-91c1-3a4df7886784" xlink:href="cf-20220930.xsd#cf_LossContingencyNumberOfProcessingFacilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_91a95893-5831-4fb9-9265-60ba51c13065" xlink:to="loc_cf_LossContingencyNumberOfProcessingFacilities_f0bb4edf-9693-4546-91c1-3a4df7886784" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesTable_6b339499-3e62-4f36-ac65-5b2dfb474dc0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LossContingenciesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LossContingenciesLineItems_91a95893-5831-4fb9-9265-60ba51c13065" xlink:to="loc_us-gaap_LossContingenciesTable_6b339499-3e62-4f36-ac65-5b2dfb474dc0" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_5a3bd558-fc2e-4062-a1b9-0bf8a8bfc322" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_6b339499-3e62-4f36-ac65-5b2dfb474dc0" xlink:to="loc_srt_StatementGeographicalAxis_5a3bd558-fc2e-4062-a1b9-0bf8a8bfc322" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_5a3bd558-fc2e-4062-a1b9-0bf8a8bfc322_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_5a3bd558-fc2e-4062-a1b9-0bf8a8bfc322" xlink:to="loc_srt_SegmentGeographicalDomain_5a3bd558-fc2e-4062-a1b9-0bf8a8bfc322_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_85ec9044-6ee0-4f55-8a2e-96881339dd7f" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_5a3bd558-fc2e-4062-a1b9-0bf8a8bfc322" xlink:to="loc_srt_SegmentGeographicalDomain_85ec9044-6ee0-4f55-8a2e-96881339dd7f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_stpr_ID_bcb33d55-8240-49a8-9e37-f98785ea1c1d" xlink:href="https://xbrl.sec.gov/stpr/2022/stpr-2022.xsd#stpr_ID"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_85ec9044-6ee0-4f55-8a2e-96881339dd7f" xlink:to="loc_stpr_ID_bcb33d55-8240-49a8-9e37-f98785ea1c1d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationStatusAxis_8f8f6c35-8bb0-4687-9b13-83ffbc14a2f1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LitigationStatusAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_6b339499-3e62-4f36-ac65-5b2dfb474dc0" xlink:to="loc_us-gaap_LitigationStatusAxis_8f8f6c35-8bb0-4687-9b13-83ffbc14a2f1" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationStatusDomain_8f8f6c35-8bb0-4687-9b13-83ffbc14a2f1_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LitigationStatusDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LitigationStatusAxis_8f8f6c35-8bb0-4687-9b13-83ffbc14a2f1" xlink:to="loc_us-gaap_LitigationStatusDomain_8f8f6c35-8bb0-4687-9b13-83ffbc14a2f1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationStatusDomain_b9e7fdf3-a517-4d11-8040-d29abc32c6a0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LitigationStatusDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LitigationStatusAxis_8f8f6c35-8bb0-4687-9b13-83ffbc14a2f1" xlink:to="loc_us-gaap_LitigationStatusDomain_b9e7fdf3-a517-4d11-8040-d29abc32c6a0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PendingLitigationMember_196cdcad-6537-4735-9bc4-957ff8522af9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PendingLitigationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LitigationStatusDomain_b9e7fdf3-a517-4d11-8040-d29abc32c6a0" xlink:to="loc_us-gaap_PendingLitigationMember_196cdcad-6537-4735-9bc4-957ff8522af9" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cfindustries.com/role/SegmentDisclosuresDetails" xlink:type="simple" xlink:href="cf-20220930.xsd#SegmentDisclosuresDetails"/>
  <link:definitionLink xlink:role="http://www.cfindustries.com/role/SegmentDisclosuresDetails" xlink:type="extended" id="ifbd51df7bbf146a1bcc1e90a83734a52_SegmentDisclosuresDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_f78a6475-ba7f-49ab-ad32-42b35eae5a01" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SegmentReportingInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_SegmentReportingGrossMarginReconcilingItemAbstract_93e0828a-a0ba-4835-a285-ad2337496253" xlink:href="cf-20220930.xsd#cf_SegmentReportingGrossMarginReconcilingItemAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_f78a6475-ba7f-49ab-ad32-42b35eae5a01" xlink:to="loc_cf_SegmentReportingGrossMarginReconcilingItemAbstract_93e0828a-a0ba-4835-a285-ad2337496253" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_5149d07e-071a-43c1-907c-dd0ee8743f5f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Revenues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cf_SegmentReportingGrossMarginReconcilingItemAbstract_93e0828a-a0ba-4835-a285-ad2337496253" xlink:to="loc_us-gaap_Revenues_5149d07e-071a-43c1-907c-dd0ee8743f5f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfRevenue_42ffb1e2-4e6d-4da9-9b23-2e10c06dc676" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CostOfRevenue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cf_SegmentReportingGrossMarginReconcilingItemAbstract_93e0828a-a0ba-4835-a285-ad2337496253" xlink:to="loc_us-gaap_CostOfRevenue_42ffb1e2-4e6d-4da9-9b23-2e10c06dc676" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_ee236259-2a51-417f-868c-c4481cc81d5f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GrossProfit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cf_SegmentReportingGrossMarginReconcilingItemAbstract_93e0828a-a0ba-4835-a285-ad2337496253" xlink:to="loc_us-gaap_GrossProfit_ee236259-2a51-417f-868c-c4481cc81d5f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingCostsAndExpenses_218b1764-64f2-46c1-9e46-4fa2583aa923" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingCostsAndExpenses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cf_SegmentReportingGrossMarginReconcilingItemAbstract_93e0828a-a0ba-4835-a285-ad2337496253" xlink:to="loc_us-gaap_OperatingCostsAndExpenses_218b1764-64f2-46c1-9e46-4fa2583aa923" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_EquityInEarningsOfOperatingAffiliates_27e79cf2-07f6-4153-b9c5-16c08da80c3a" xlink:href="cf-20220930.xsd#cf_EquityInEarningsOfOperatingAffiliates"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cf_SegmentReportingGrossMarginReconcilingItemAbstract_93e0828a-a0ba-4835-a285-ad2337496253" xlink:to="loc_cf_EquityInEarningsOfOperatingAffiliates_27e79cf2-07f6-4153-b9c5-16c08da80c3a" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_072dea5a-ae7f-4a75-a84b-52db875a21b2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cf_SegmentReportingGrossMarginReconcilingItemAbstract_93e0828a-a0ba-4835-a285-ad2337496253" xlink:to="loc_us-gaap_OperatingIncomeLoss_072dea5a-ae7f-4a75-a84b-52db875a21b2" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfDerivatives_b67db87d-a18e-4177-ab2b-c4e686412e86" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GainLossOnSaleOfDerivatives"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_f78a6475-ba7f-49ab-ad32-42b35eae5a01" xlink:to="loc_us-gaap_GainLossOnSaleOfDerivatives_b67db87d-a18e-4177-ab2b-c4e686412e86" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_bc268635-5f56-401b-8cc8-5006e9ab9622" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_f78a6475-ba7f-49ab-ad32-42b35eae5a01" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_bc268635-5f56-401b-8cc8-5006e9ab9622" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsAxis_520a1b59-469e-4372-83c8-b12dcf75c7e5" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidationItemsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_bc268635-5f56-401b-8cc8-5006e9ab9622" xlink:to="loc_srt_ConsolidationItemsAxis_520a1b59-469e-4372-83c8-b12dcf75c7e5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_520a1b59-469e-4372-83c8-b12dcf75c7e5_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ConsolidationItemsAxis_520a1b59-469e-4372-83c8-b12dcf75c7e5" xlink:to="loc_srt_ConsolidationItemsDomain_520a1b59-469e-4372-83c8-b12dcf75c7e5_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_327e4393-f24c-4272-b9ec-d054b9834af8" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ConsolidationItemsAxis_520a1b59-469e-4372-83c8-b12dcf75c7e5" xlink:to="loc_srt_ConsolidationItemsDomain_327e4393-f24c-4272-b9ec-d054b9834af8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingSegmentsMember_909855aa-663b-4d38-91c8-67bfadcc2a7e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingSegmentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidationItemsDomain_327e4393-f24c-4272-b9ec-d054b9834af8" xlink:to="loc_us-gaap_OperatingSegmentsMember_909855aa-663b-4d38-91c8-67bfadcc2a7e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_c413d542-e183-44f3-ad47-2fc712525389" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_bc268635-5f56-401b-8cc8-5006e9ab9622" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_c413d542-e183-44f3-ad47-2fc712525389" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_c413d542-e183-44f3-ad47-2fc712525389_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_c413d542-e183-44f3-ad47-2fc712525389" xlink:to="loc_us-gaap_SegmentDomain_c413d542-e183-44f3-ad47-2fc712525389_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_e822a9e8-fb2a-4800-a640-f961d886685b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_c413d542-e183-44f3-ad47-2fc712525389" xlink:to="loc_us-gaap_SegmentDomain_e822a9e8-fb2a-4800-a640-f961d886685b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_AmmoniaMember_702ad5a9-4496-4542-bf65-5b70919bcfe2" xlink:href="cf-20220930.xsd#cf_AmmoniaMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_e822a9e8-fb2a-4800-a640-f961d886685b" xlink:to="loc_cf_AmmoniaMember_702ad5a9-4496-4542-bf65-5b70919bcfe2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_UreaMember_ffbfb342-5976-4af3-bb23-9f7a52d5d1af" xlink:href="cf-20220930.xsd#cf_UreaMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_e822a9e8-fb2a-4800-a640-f961d886685b" xlink:to="loc_cf_UreaMember_ffbfb342-5976-4af3-bb23-9f7a52d5d1af" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_UANMember_8d816c66-275c-4f3a-8ae2-2acd22ccf1a4" xlink:href="cf-20220930.xsd#cf_UANMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_e822a9e8-fb2a-4800-a640-f961d886685b" xlink:to="loc_cf_UANMember_8d816c66-275c-4f3a-8ae2-2acd22ccf1a4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_AmmoniumNitrateSegmentMember_924bf98e-46c7-49a1-8f3c-dbe2075dcddc" xlink:href="cf-20220930.xsd#cf_AmmoniumNitrateSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_e822a9e8-fb2a-4800-a640-f961d886685b" xlink:to="loc_cf_AmmoniumNitrateSegmentMember_924bf98e-46c7-49a1-8f3c-dbe2075dcddc" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_OtherProductsMember_8518731f-0fc8-4c48-8f20-021d1f6b751a" xlink:href="cf-20220930.xsd#cf_OtherProductsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_e822a9e8-fb2a-4800-a640-f961d886685b" xlink:to="loc_cf_OtherProductsMember_8518731f-0fc8-4c48-8f20-021d1f6b751a" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnusualOrInfrequentItemAxis_775058c1-b83e-41ff-9e2f-546be066bf6f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_UnusualOrInfrequentItemAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_bc268635-5f56-401b-8cc8-5006e9ab9622" xlink:to="loc_us-gaap_UnusualOrInfrequentItemAxis_775058c1-b83e-41ff-9e2f-546be066bf6f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnusualOrInfrequentItemDomain_775058c1-b83e-41ff-9e2f-546be066bf6f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_UnusualOrInfrequentItemDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_UnusualOrInfrequentItemAxis_775058c1-b83e-41ff-9e2f-546be066bf6f" xlink:to="loc_us-gaap_UnusualOrInfrequentItemDomain_775058c1-b83e-41ff-9e2f-546be066bf6f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnusualOrInfrequentItemDomain_7ae42018-87ba-40f0-a757-0228b7127275" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_UnusualOrInfrequentItemDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_UnusualOrInfrequentItemAxis_775058c1-b83e-41ff-9e2f-546be066bf6f" xlink:to="loc_us-gaap_UnusualOrInfrequentItemDomain_7ae42018-87ba-40f0-a757-0228b7127275" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_WinterStormUriMember_49517538-0370-4f5a-9468-aa08fe9887ea" xlink:href="cf-20220930.xsd#cf_WinterStormUriMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_UnusualOrInfrequentItemDomain_7ae42018-87ba-40f0-a757-0228b7127275" xlink:to="loc_cf_WinterStormUriMember_49517538-0370-4f5a-9468-aa08fe9887ea" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cfindustries.com/role/SubsequentEventDetails" xlink:type="simple" xlink:href="cf-20220930.xsd#SubsequentEventDetails"/>
  <link:definitionLink xlink:role="http://www.cfindustries.com/role/SubsequentEventDetails" xlink:type="extended" id="id311c095858046e79af67eec5c1c4f34_SubsequentEventDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventLineItems_f7d5a545-291c-4701-9291-10167971ecb5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_20561492-455d-49cd-b389-34aacadc4281" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockRepurchaseProgramAuthorizedAmount1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_f7d5a545-291c-4701-9291-10167971ecb5" xlink:to="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_20561492-455d-49cd-b389-34aacadc4281" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTable_bbccdd8d-0d26-416b-8b7c-e16a79cf25c1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SubsequentEventLineItems_f7d5a545-291c-4701-9291-10167971ecb5" xlink:to="loc_us-gaap_SubsequentEventTable_bbccdd8d-0d26-416b-8b7c-e16a79cf25c1" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidatedEntitiesAxis_74570255-c0a0-4c44-b4fb-1a7376e47bb2" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_bbccdd8d-0d26-416b-8b7c-e16a79cf25c1" xlink:to="loc_srt_ConsolidatedEntitiesAxis_74570255-c0a0-4c44-b4fb-1a7376e47bb2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidatedEntitiesDomain_74570255-c0a0-4c44-b4fb-1a7376e47bb2_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ConsolidatedEntitiesAxis_74570255-c0a0-4c44-b4fb-1a7376e47bb2" xlink:to="loc_srt_ConsolidatedEntitiesDomain_74570255-c0a0-4c44-b4fb-1a7376e47bb2_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidatedEntitiesDomain_5fbb45ca-8b80-417d-abde-8850c2d5b94a" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ConsolidatedEntitiesAxis_74570255-c0a0-4c44-b4fb-1a7376e47bb2" xlink:to="loc_srt_ConsolidatedEntitiesDomain_5fbb45ca-8b80-417d-abde-8850c2d5b94a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SubsidiariesMember_065cb439-8eba-49f3-a8c5-7b9cd305a57e" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SubsidiariesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidatedEntitiesDomain_5fbb45ca-8b80-417d-abde-8850c2d5b94a" xlink:to="loc_srt_SubsidiariesMember_065cb439-8eba-49f3-a8c5-7b9cd305a57e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_83337116-bf3d-4f21-8b3f-b7255b4ccf01" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_bbccdd8d-0d26-416b-8b7c-e16a79cf25c1" xlink:to="loc_us-gaap_DebtInstrumentAxis_83337116-bf3d-4f21-8b3f-b7255b4ccf01" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_83337116-bf3d-4f21-8b3f-b7255b4ccf01_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_83337116-bf3d-4f21-8b3f-b7255b4ccf01" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_83337116-bf3d-4f21-8b3f-b7255b4ccf01_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_c66b03b6-0a64-4c0b-8f5a-308e74fa1932" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_83337116-bf3d-4f21-8b3f-b7255b4ccf01" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_c66b03b6-0a64-4c0b-8f5a-308e74fa1932" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cf_SeniorNotes3.450PercentDue2023Member_7167e067-4201-4dc3-ad9c-111444a36479" xlink:href="cf-20220930.xsd#cf_SeniorNotes3.450PercentDue2023Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_c66b03b6-0a64-4c0b-8f5a-308e74fa1932" xlink:to="loc_cf_SeniorNotes3.450PercentDue2023Member_7167e067-4201-4dc3-ad9c-111444a36479" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_92efc10e-e858-495d-82b9-fa547f87c878" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_bbccdd8d-0d26-416b-8b7c-e16a79cf25c1" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_92efc10e-e858-495d-82b9-fa547f87c878" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_92efc10e-e858-495d-82b9-fa547f87c878_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_92efc10e-e858-495d-82b9-fa547f87c878" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_92efc10e-e858-495d-82b9-fa547f87c878_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_c885df46-c149-49c3-a334-7e017a1098e1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_92efc10e-e858-495d-82b9-fa547f87c878" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_c885df46-c149-49c3-a334-7e017a1098e1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeniorNotesMember_550d0313-1ff9-4e59-a636-b25e40480ce0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_c885df46-c149-49c3-a334-7e017a1098e1" xlink:to="loc_us-gaap_SeniorNotesMember_550d0313-1ff9-4e59-a636-b25e40480ce0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_8d5d70ec-6a02-49ec-b0a1-f82ab3d6ba98" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_bbccdd8d-0d26-416b-8b7c-e16a79cf25c1" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_8d5d70ec-6a02-49ec-b0a1-f82ab3d6ba98" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_8d5d70ec-6a02-49ec-b0a1-f82ab3d6ba98_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_8d5d70ec-6a02-49ec-b0a1-f82ab3d6ba98" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_8d5d70ec-6a02-49ec-b0a1-f82ab3d6ba98_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_46aa6c7d-6170-4f4e-99a4-780191b1abec" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_8d5d70ec-6a02-49ec-b0a1-f82ab3d6ba98" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_46aa6c7d-6170-4f4e-99a4-780191b1abec" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_07ab337b-a28f-438f-8d25-25c53ef35296" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_46aa6c7d-6170-4f4e-99a4-780191b1abec" xlink:to="loc_us-gaap_SubsequentEventMember_07ab337b-a28f-438f-8d25-25c53ef35296" xlink:type="arc" order="0"/>
  </link:definitionLink>
</link:linkbase>
