<SEC-DOCUMENT>0001035443-24-000171.txt : 20240606
<SEC-HEADER>0001035443-24-000171.hdr.sgml : 20240606
<ACCEPTANCE-DATETIME>20240606184554
ACCESSION NUMBER:		0001035443-24-000171
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20240604
FILED AS OF DATE:		20240606
DATE AS OF CHANGE:		20240606

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			ALEXANDRIA REAL ESTATE EQUITIES, INC.
		CENTRAL INDEX KEY:			0001035443
		STANDARD INDUSTRIAL CLASSIFICATION:	REAL ESTATE INVESTMENT TRUSTS [6798]
		ORGANIZATION NAME:           	05 Real Estate & Construction
		STATE OF INCORPORATION:			MD
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-38898
		FILM NUMBER:		241026755

	BUSINESS ADDRESS:	
		STREET 1:		26 NORTH EUCLID AVENUE
		CITY:			PASADENA
		STATE:			CA
		ZIP:			91101
		BUSINESS PHONE:		6265780777

	MAIL ADDRESS:	
		STREET 1:		26 NORTH EUCLID AVENUE
		CITY:			PASADENA
		STATE:			CA
		ZIP:			91101

	FORMER NAME:	
		FORMER CONFORMED NAME:	ALEXANDRIA REAL ESTATE EQUITIES INC
		DATE OF NAME CHANGE:	19970311

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Alexandria Equities No. 7, LLC
		CENTRAL INDEX KEY:			0001776437
		ORGANIZATION NAME:           	
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-38898
		FILM NUMBER:		241026753

	BUSINESS ADDRESS:	
		STREET 1:		26 NORTH EUCLID AVENUE
		CITY:			PASADENA
		STATE:			CA
		ZIP:			91101
		BUSINESS PHONE:		626-578-0777

	MAIL ADDRESS:	
		STREET 1:		26 NORTH EUCLID AVENUE
		CITY:			PASADENA
		STATE:			CA
		ZIP:			91101

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Alexandria Venture Investments, LLC
		CENTRAL INDEX KEY:			0001722024
		ORGANIZATION NAME:           	
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-38898
		FILM NUMBER:		241026754

	BUSINESS ADDRESS:	
		STREET 1:		26 NORTH EUCLID AVENUE
		CITY:			PASADENA
		STATE:			CA
		ZIP:			91101
		BUSINESS PHONE:		626-578-0777

	MAIL ADDRESS:	
		STREET 1:		26 NORTH EUCLID AVENUE
		CITY:			PASADENA
		STATE:			CA
		ZIP:			91101

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Applied Therapeutics, Inc.
		CENTRAL INDEX KEY:			0001697532
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		545 FIFTH AVENUE, SUITE 1400
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10017
		BUSINESS PHONE:		212-220-9226

	MAIL ADDRESS:	
		STREET 1:		545 FIFTH AVENUE, SUITE 1400
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10017

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Applied Therapeutics Inc.
		DATE OF NAME CHANGE:	20170208
</SEC-HEADER>
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<TYPE>4
<SEQUENCE>1
<FILENAME>wk-form4_1717713946.xml
<DESCRIPTION>FORM 4
<TEXT>
<XML>
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<ownershipDocument>

    <schemaVersion>X0508</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2024-06-04</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001697532</issuerCik>
        <issuerName>Applied Therapeutics, Inc.</issuerName>
        <issuerTradingSymbol>APLT</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001035443</rptOwnerCik>
            <rptOwnerName>ALEXANDRIA REAL ESTATE EQUITIES, INC.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>26 NORTH EUCLID AVENUE</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>PASADENA</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>91101</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001722024</rptOwnerCik>
            <rptOwnerName>Alexandria Venture Investments, LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>26 NORTH EUCLID AVENUE</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>PASADENA</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>91101</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001776437</rptOwnerCik>
            <rptOwnerName>Alexandria Equities No. 7, LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>26 NORTH EUCLID AVENUE</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>PASADENA</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>91101</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <aff10b5One>0</aff10b5One>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2024-06-04</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>150000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>4.21</value>
                    <footnoteId id="F1"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>6005077</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By subsidiary</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2024-06-05</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>150000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>4.24</value>
                    <footnoteId id="F3"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>5855077</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By subsidiary</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>203977</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By subsidiary</value>
                    <footnoteId id="F4"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">The price reported in Column 4 is a weighted average price. The shares were sold at prices ranging from $4.12 to $4.32. The reporting person will provide upon request to the SEC, the issuer or security holder of the issuer, full information regarding the number of shares sold at each separate price.</footnote>
        <footnote id="F2">These securities are held directly by Alexandria Venture Investments, LLC, an affiliate of Alexandria Equities No. 7, LLC (&quot;AE7&quot;), and a wholly owned subsidiary of Alexandria Real Estate Equities, Inc.</footnote>
        <footnote id="F3">The price reported in Column 4 is a weighted average price. The shares were sold at prices ranging from $4.10 to $4.40. The reporting person will provide upon request to the SEC, the issuer or security holder of the issuer, full information regarding the number of shares sold at each separate price.</footnote>
        <footnote id="F4">These securities are held directly by AE7, a wholly owned subsidiary of Alexandria Real Estate Equities, Inc.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>ALEXANDRIA REAL ESTATE EQUITIES, INC., By: /s/ Marc E. Binda, Chief Financial Officer and Treasurer</signatureName>
        <signatureDate>2024-06-06</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>ALEXANDRIA EQUITIES NO. 7, LLC By: ARE-Special Services, LLC, managing member By: AREE, L.P., managing member By: ARE-QRS CORP., general partner By: Alexandria Real Estate Equities, Inc. By: /s/ Marc E. Binda, Chief Financial Officer and Treasurer</signatureName>
        <signatureDate>2024-06-06</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>ALEXANDRIA VENTURE INVESTMENTS, LLC., By: Alexandria Real Estate Equities, Inc., managing member By: /s/ Marc E. Binda, Chief Financial Officer and Treasurer</signatureName>
        <signatureDate>2024-06-06</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
