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Research and Development Prepaid Expenses and Accrued Liabilities (Details) - USD ($) $ in Thousands | Dec. 31, 2021 | Dec. 31, 2020
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Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Abstract] |  |
Prepaid research and development expenditures | $ 6,138 | $ 8,490
Accrued research and development expenditure | $ 5,226 | $ 1,502

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