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Income Tax - Reconciliation of the effective income tax rate to statutory rate (Details)
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Income Tax Disclosure [Abstract]    
U.S. federal income tax statutory rate 21.00% 21.00%
Change in valuation allowance (10.50%) (12.10%)
Non-deductible expenses (0.40%) (3.90%)
Refundable research and development tax credit (8.30%) (7.00%)
Effect of foreign operations taxed at various rates 0.50% 0.90%
Stock-based compensation (1.60%) 0.00%
Other (0.70%) 1.40%
Effective tax rate 0.00% 0.30%