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Consolidated Statements of Stockholders' Equity - USD ($)
$ in Thousands
Total
Common Stock
Additional Paid-In Capital
Accumulated Other Comprehensive Loss
Total Accumulated Deficit
Beginning balance (in shares) at Dec. 31, 2019   67,178,054      
Beginning balance at Dec. 31, 2019 $ 78,863 $ 672 $ 241,204 $ (4,764) $ (158,249)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Private placement/Rights offering of common stock, net of offering costs (in shares)   14,970,060      
Private placement/Rights offering of common stock, net of offering costs 49,952 $ 150 49,802    
Fractional shares issued from reverse stock split   3      
Issuance on common stock from exercise of share options (in shares)   426,947      
Issuance on common stock from exercise of share options 599 $ 4 595    
Stock-based compensation 1,766   1,766    
Foreign currency translation adjustment 970     970  
Net loss $ (52,697)       (52,697)
Ending balance (in shares) at Dec. 31, 2020 82,575,064 82,575,064      
Ending balance at Dec. 31, 2020 $ 79,453 $ 826 293,367 (3,794) (210,946)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Private placement/Rights offering of common stock, net of offering costs (in shares)   14,312,976      
Private placement/Rights offering of common stock, net of offering costs $ 74,841 $ 143 74,698    
Issuance on common stock from exercise of share options (in shares) 1,124,577 1,151,500      
Issuance on common stock from exercise of share options $ 3,088 $ 11 3,077    
Stock-based compensation 12,804   12,804    
Imputed interest expense on promissory note payable to a related party 103   103    
Foreign currency translation adjustment 1,597     1,597  
Net loss $ (88,602)       (88,602)
Ending balance (in shares) at Dec. 31, 2021 98,039,540 98,039,540      
Ending balance at Dec. 31, 2021 $ 83,284 $ 980 $ 384,049 $ (2,197) $ (299,548)