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Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands | Total | Rights Offering | Private placement | Common Stock | Common Stock Rights Offering | Common Stock Private placement | Additional Paid-In Capital | Additional Paid-In Capital Rights Offering | Additional Paid-In Capital Private placement | Accumulated Other Comprehensive Loss | Total Accumulated Deficit
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Beginning balance (in shares) at Dec. 31, 2021 |  |  |  | 98,039,540 |  |  |  |  |  |  |
Beginning balance at Dec. 31, 2021 | $ 83,284 |  |  | $ 980 |  |  | $ 384,049 |  |  | $ (2,197) | $ (299,548)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |
Rights Offering of common stock, net of offering costs/ Private placement of common stock (in shares) |  |  |  | 103,092,783 |  |  |  |  |  |  |
Rights Offering of common stock, net of offering costs/ Private placement of common stock | 99,889 |  |  | $ 1,031 |  |  | 98,858 |  |  |  |
Issuance of common stock in lieu of interest to related parties (in shares) |  |  |  | 9,720,291 |  |  |  |  |  |  |
Issuance of common stock in lieu of interest to related parties | 7,594 |  |  | $ 97 |  |  | 7,497 |  |  |  |
Issuance of common stock under stock purchase plans and exercise of stock options (in shares) |  |  |  | 238,811 |  |  |  |  |  |  |
Issuance of common stock under stock purchase plans and exercise of stock options | 399 |  |  | $ 2 |  |  | 397 |  |  |  |
Stock-based compensation | 11,948 |  |  |  |  |  | 11,948 |  |  |  |
Imputed interest expense on promissory note payable to a related party | 2,018 |  |  |  |  |  | 2,018 |  |  |  |
Unrealized gain on short-term investments | 0 |  |  |  |  |  |  |  |  |  |
Reclassification of cumulative translation gain (Note 10) | 0 |  |  |  |  |  |  |  |  |  |
Foreign currency translation adjustment | 304 |  |  |  |  |  |  |  |  | 304 |
Net loss | $ (78,782) |  |  |  |  |  |  |  |  |  | (78,782)
Ending balance (in shares) at Dec. 31, 2022 | 211,091,425 |  |  | 211,091,425 |  |  |  |  |  |  |
Ending balance at Dec. 31, 2022 | $ 126,654 |  |  | $ 2,110 |  |  | 504,767 |  |  | (1,893) | (378,330)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |
Rights Offering of common stock, net of offering costs/ Private placement of common stock (in shares) |  |  |  |  | 476,190,471 | 2,976,190 |  |  |  |  |
Rights Offering of common stock, net of offering costs/ Private placement of common stock |  | $ 499,381 | $ 5,000 |  | $ 4,762 | $ 30 |  | $ 494,619 | $ 4,970 |  |
Exercise of warrants (in shares) |  |  |  | 805,495 |  |  |  |  |  |  |
Exercise of warrants | 1,203 |  |  | $ 8 |  |  | 1,195 |  |  |  |
Issuance of common stock under stock purchase plans and exercise of stock options (in shares) |  |  |  | 596,472 |  |  |  |  |  |  |
Issuance of common stock under stock purchase plans and exercise of stock options | 929 |  |  | $ 7 |  |  | 922 |  |  |  |
Issuance of common stock in lieu of cash for Akeso upfront payment (in shares) |  |  |  | 10,000,000 |  |  |  |  |  |  |
Issuance of common stock in lieu of cash for Akeso upfront payment | 45,900 |  |  | $ 100 |  |  | 45,800 |  |  |  |
Stock-based compensation | 14,108 |  |  |  |  |  | 14,108 |  |  |  |
Unrealized gain on short-term investments | 36 |  |  |  |  |  |  |  |  | 36 |
Reclassification of cumulative translation gain (Note 10) | (419) |  |  |  |  |  |  |  |  | (419) |
Foreign currency translation adjustment | (172) |  |  |  |  |  |  |  |  | (172) |
Net loss | $ (614,928) |  |  |  |  |  |  |  |  |  | (614,928)
Ending balance (in shares) at Dec. 31, 2023 | 701,660,053 |  |  | 701,660,053 |  |  |  |  |  |  |
Ending balance at Dec. 31, 2023 | $ 77,692 |  |  | $ 7,017 |  |  | $ 1,066,381 |  |  | $ (2,448) | $ (993,258)

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