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Consolidated Statements of Stockholders' Equity - USD ($)
$ in Thousands
Total
Rights Offering
Private placement
Common Stock
Common Stock
Rights Offering
Common Stock
Private placement
Additional Paid-In Capital
Additional Paid-In Capital
Rights Offering
Additional Paid-In Capital
Private placement
Accumulated Other Comprehensive Loss
Total Accumulated Deficit
Beginning balance (in shares) at Dec. 31, 2021       98,039,540              
Beginning balance at Dec. 31, 2021 $ 83,284     $ 980     $ 384,049     $ (2,197) $ (299,548)
Increase (Decrease) in Stockholders' Equity [Roll Forward]                      
Rights Offering of common stock, net of offering costs/ Private placement of common stock (in shares)       103,092,783              
Rights Offering of common stock, net of offering costs/ Private placement of common stock 99,889     $ 1,031     98,858        
Issuance of common stock in lieu of interest to related parties (in shares)       9,720,291              
Issuance of common stock in lieu of interest to related parties 7,594     $ 97     7,497        
Issuance of common stock under stock purchase plans and exercise of stock options (in shares)       238,811              
Issuance of common stock under stock purchase plans and exercise of stock options 399     $ 2     397        
Stock-based compensation 11,948           11,948        
Imputed interest expense on promissory note payable to a related party 2,018           2,018        
Unrealized gain on short-term investments 0                    
Reclassification of cumulative translation gain (Note 10) 0                    
Foreign currency translation adjustment 304                 304  
Net loss $ (78,782)                   (78,782)
Ending balance (in shares) at Dec. 31, 2022 211,091,425     211,091,425              
Ending balance at Dec. 31, 2022 $ 126,654     $ 2,110     504,767     (1,893) (378,330)
Increase (Decrease) in Stockholders' Equity [Roll Forward]                      
Rights Offering of common stock, net of offering costs/ Private placement of common stock (in shares)         476,190,471 2,976,190          
Rights Offering of common stock, net of offering costs/ Private placement of common stock   $ 499,381 $ 5,000   $ 4,762 $ 30   $ 494,619 $ 4,970    
Exercise of warrants (in shares)       805,495              
Exercise of warrants 1,203     $ 8     1,195        
Issuance of common stock under stock purchase plans and exercise of stock options (in shares)       596,472              
Issuance of common stock under stock purchase plans and exercise of stock options 929     $ 7     922        
Issuance of common stock in lieu of cash for Akeso upfront payment (in shares)       10,000,000              
Issuance of common stock in lieu of cash for Akeso upfront payment 45,900     $ 100     45,800        
Stock-based compensation 14,108           14,108        
Unrealized gain on short-term investments 36                 36  
Reclassification of cumulative translation gain (Note 10) (419)                 (419)  
Foreign currency translation adjustment (172)                 (172)  
Net loss $ (614,928)                   (614,928)
Ending balance (in shares) at Dec. 31, 2023 701,660,053     701,660,053              
Ending balance at Dec. 31, 2023 $ 77,692     $ 7,017     $ 1,066,381     $ (2,448) $ (993,258)