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v3.25.4

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2025 | Dec. 31, 2024 | Dec. 31, 2023
Cash flows used in operating activities: |  |  |  |
Net loss |  | $ (1,079,586) | $ (221,315) | $ (614,928)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |  |
Non-cash interest expense |  | 0 | 0 | 6,253
Amortization of discount on short-term investments |  | (7,006) | (2,576) | (1,924)
Unrealized foreign exchange loss (gain) |  | (320) | 229 | (812)
Reclassification of currency translation gain |  | 0 | 0 | (419)
Impairment of fixed assets |  | 0 | 0 | 474
Depreciation |  | 146 | 89 | 198
Stock-based compensation |  | 732,420 | 50,981 | 14,108
Loss on disposal of assets |  | 0 | 0 | (109)
Acquired in-process research and development expense |  | 0 | 15,007 | 520,915
Changes in operating assets and liabilities: |  |  |  |
Prepaid expenses and other current assets |  | 4,866 | (7,370) | 3,613
Other assets |  | (4,875) | 2,470 | (3,421)
Accounts payable |  | 15,303 | 2,015 | 2,263
Accrued liabilities and other current liabilities |  | 12,930 | 11,879 | (2,377)
Accrued compensation |  | 2,909 | 6,557 | (235)
Other long-term liabilities |  | 80 | 95 | 0
Operating lease right-of-use assets and lease liabilities, net |  | 203 | (167) | (359)
Net cash used in operating activities |  | (322,930) | (142,106) | (76,760)
Cash flows used in investing activities: |  |  |  |
Maturities and sales of short-term investments |  | 311,340 | 489,837 | 208,165
Purchase of short-term investments |  | (484,993) | (680,032) | (321,022)
Purchase of property and equipment |  | (657) | (139) | (128)
Proceeds from sale of property, plant and equipment |  | 0 | 0 | 226
Payments to Akeso for upfront milestone payments and associated direct transaction costs |  | 0 | (15,007) | (475,015)
Net cash used in investing activities |  | (174,310) | (205,341) | (587,774)
Cash flows provided by financing activities: |  |  |  |
Proceeds from the issuance of common stock via private placements, net of offering costs | [1] | 500,037 | 434,860 | 5,000
Proceeds from exercise of warrants | [1] | 7,315 | 598 | 1,203
Proceeds received related to employee stock purchase plan and exercise of stock options |  | 5,653 | 2,736 | 929
Transaction costs from the issuance of common stock for rights offering |  | 0 | 0 | (619)
Re-payment of related party promissory notes |  | 0 | (100,000) | (24,686)
Net cash provided by financing activities |  | 617,533 | 381,227 | 86,513
Effect of exchange rates on cash and cash equivalents |  | 102 | (18) | 839
Increase (decrease) in cash, cash equivalents and restricted cash |  | 120,395 | 33,762 | (577,182)
Cash, cash equivalents and restricted cash at beginning of period |  | 105,187 | 71,425 | 648,607
Cash, cash equivalents and restricted cash at end of period |  | 225,582 | 105,187 | 71,425
Supplemental Disclosure of Cash Flow Information: |  |  |  |
Cash paid for interest on related party promissory note |  | 0 | 8,806 | 10,650
Cash paid for income taxes |  | 0 | 0 | 52
Supplemental Disclosure of Non-Cash Investing and Financing Activities: |  |  |  |
Leased assets obtained in exchange for operating lease liabilities |  | 17,056 | 4,216 | 4,245
Unpaid amounts related to purchase of property, plant and equipment |  | 291 | 0 | 0
At Market Offering |  |  |  |
Cash flows provided by financing activities: |  |  |  |
Proceeds from issuance of common stock |  | 104,528 | 43,033 | 0
Rights Offering |  |  |  |
Cash flows provided by financing activities: |  |  |  |
Proceeds from issuance of common stock | [1] | 0 | 0 | 104,686
Supplemental Disclosure of Non-Cash Investing and Financing Activities: |  |  |  |
Issuance of common stock |  | 0 | 0 | 395,314
Akeso License Agreement |  |  |  |
Supplemental Disclosure of Non-Cash Investing and Financing Activities: |  |  |  |
Issuance of common stock |  | $ 0 | $ 0 | $ 45,900
[1] | Refer to Note 13 – Stockholders’ Equity for related party transactions.

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