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Consolidated Statements of Stockholders' Equity - USD ($)
$ in Thousands
Total
Rights Offering
 [1]
Private Placement
At Market Offering
Common Stock
Common Stock
Rights Offering
 [1]
Common Stock
Private Placement
Common Stock
At Market Offering
Additional Paid-In Capital
Additional Paid-In Capital
Rights Offering
 [1]
Additional Paid-In Capital
Private Placement
Additional Paid-In Capital
At Market Offering
Accumulated Other Comprehensive Loss
Total Accumulated Deficit
Beginning balance (in shares) at Dec. 31, 2022         211,091,425                  
Beginning balance at Dec. 31, 2022 $ 126,654       $ 2,110       $ 504,767       $ (1,893) $ (378,330)
Increase (Decrease) in Stockholders' Equity [Roll Forward]                            
Rights Offering of common stock, net of offering costs / Private placement of common stock, net of offering costs / Proceeds from at-the-market offering, net of commissions and offering costs (in shares)           476,190,471 2,976,190              
Rights Offering of common stock, net of offering costs / Private placement of common stock, net of offering costs / Proceeds from at-the-market offering, net of commissions and offering costs   $ 499,381 $ 5,000     $ 4,762 $ 30     $ 494,619 $ 4,970      
Issuance of common stock under employee stock purchase plans and exercise of stock options and warrants (in shares)         596,472                  
Issuance of common stock under stock purchase plans and exercise of stock options and warrants 929       $ 7       922          
Issuance of common stock in lieu of cash for Akeso upfront payment (in shares)         10,000,000                  
Issuance of common stock in lieu of cash for Akeso upfront payment 45,900       $ 100       45,800          
Exercise of warrants (in shares) [1]         805,495                  
Exercise of warrants [1] 1,203       $ 8       1,195          
Stock-based compensation 14,108               14,108          
Net other comprehensive (loss) gain (555)                       (555)  
Net loss (614,928)                         (614,928)
Ending balance (in shares) at Dec. 31, 2023         701,660,053                  
Ending balance at Dec. 31, 2023 77,692       $ 7,017       1,066,381       (2,448) (993,258)
Increase (Decrease) in Stockholders' Equity [Roll Forward]                            
Rights Offering of common stock, net of offering costs / Private placement of common stock, net of offering costs / Proceeds from at-the-market offering, net of commissions and offering costs (in shares)             32,574,640 [1] 1,807,093            
Rights Offering of common stock, net of offering costs / Private placement of common stock, net of offering costs / Proceeds from at-the-market offering, net of commissions and offering costs     434,860 [1] $ 43,033     $ 326 [1] $ 18     434,534 [1] $ 43,015    
Issuance of common stock under employee stock purchase plans and exercise of stock options and warrants (in shares)         1,584,218                  
Issuance of common stock under stock purchase plans and exercise of stock options and warrants 3,334       $ 15       3,319          
Stock-based compensation 50,981               50,981          
Net other comprehensive (loss) gain 163                       163  
Net loss $ (221,315)                         (221,315)
Ending balance (in shares) at Dec. 31, 2024 737,626,004       737,626,004                  
Ending balance at Dec. 31, 2024 $ 388,748       $ 7,376       1,598,230       (2,285) (1,214,573)
Increase (Decrease) in Stockholders' Equity [Roll Forward]                            
Rights Offering of common stock, net of offering costs / Private placement of common stock, net of offering costs / Proceeds from at-the-market offering, net of commissions and offering costs (in shares)             26,682,846 [1] 5,339,339            
Rights Offering of common stock, net of offering costs / Private placement of common stock, net of offering costs / Proceeds from at-the-market offering, net of commissions and offering costs     $ 500,037 [1] $ 104,528     $ 267 [1] $ 53     $ 499,770 [1] $ 104,475    
Issuance of common stock under employee stock purchase plans and exercise of stock options and warrants (in shares)         5,723,011                  
Issuance of common stock under stock purchase plans and exercise of stock options and warrants 12,968       $ 58       12,910          
Stock-based compensation 732,420               732,420          
Net other comprehensive (loss) gain (255)                       (255)  
Net loss $ (1,079,586)                         (1,079,586)
Ending balance (in shares) at Dec. 31, 2025 775,371,200       775,371,200                  
Ending balance at Dec. 31, 2025 $ 658,860       $ 7,754       $ 2,947,805       $ (2,540) $ (2,294,159)
[1] Refer to Note 13 – Stockholders’ Equity for related party transactions.